NCT02066623

Brief Summary

The German-Austrian ABSORB Register shall provide an analysis of acute and long-term safety as well as therapy outcomes of the ABSORB (trade mark) bioresorbable vascular scaffold system in patients suffering from coronary artery disease.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,330

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2013

Longer than P75 for all trials

Geographic Reach
2 countries

81 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 8, 2013

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

January 20, 2014

Completed
1 month until next milestone

First Posted

Study publicly available on registry

February 19, 2014

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2016

Completed
5.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 6, 2021

Completed
Last Updated

April 1, 2022

Status Verified

July 1, 2021

Enrollment Period

2.2 years

First QC Date

January 20, 2014

Last Update Submit

March 31, 2022

Conditions

Keywords

coronary artery stenosis, vascular scaffold, ABSORB

Outcome Measures

Primary Outcomes (1)

  • Number of serious adverse cardiac events

    The following events will be evaluated: * Death * Myocardial infarction * Clinically motivated target vessel revascularization * Clinically motivated target lesion revascularization * Composite target parameter of the aforementioned events (MACE, major adverse cardiac event) as the primary target parameter * Stroke * Composite target parameter of the aforementioned events including stroke as the primary target parameter (MACCE, major adverse cardiac and cerebrovascular event) * Stent thrombosis

    5 years after index procedure

Secondary Outcomes (1)

  • Success of ABSORB implantation

    during implantation of ABSORB scaffold

Other Outcomes (3)

  • Effectiveness of ABSORB implantation

    5 years follow-up period

  • Change in quality of life

    5 years follow-up period

  • Health-economical effects of ABSORB scaffold implantation

    5 years follow-up period

Study Arms (1)

Implantation of ABSORB Scaffold

Patients suffering from coronary artery stenosis with an indication for implantation of ABSORB scaffold

Device: ABSORB Scaffold

Interventions

Implantation of a drug-eluting vascular scaffold, which is completely resorbable to improve the blood flow in coronary arteries in the presence of stenosis

Also known as: ABSORBTM Everolimus-eluting Bioresorbable Vascular Scaffold
Implantation of ABSORB Scaffold

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All patients in Germany and Austria having been implanted with ABSORB scaffold system

You may qualify if:

  • ABSORB implant scheduled
  • Age 18+
  • Patients giving consent to keep scheduled follow-ups
  • Signed informed consent

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (81)

Medizinische Universität Wien

Vienna, Vienna, A-1090, Austria

Location

Landeskrankenhaus-Univ.Klinikum Graz

Graz, Austria

Location

LKH Graz-West

Graz, Austria

Location

Medizinische Universität Innsbruck

Innsbruck, Austria

Location

A.ö. Krankenhaus der Stadt Linz

Linz, Austria

Location

LKH Villach

Villach, Austria

Location

Ilm-Kreis-Kliniken, Arnstadt-Ilmenau

Arnstadt, Germany

Location

Zentralklinik Bad Berka

Bad Berka, Germany

Location

SLK-Kliniken, Klinikum am Plattenwald

Bad Friedrichshall, Germany

Location

Herzzentrum Bad Krozingen

Bad Krozingen, Germany

Location

Hufeland Klinikum

Bad Langensalza, Germany

Location

Kerckhoff-Klinik

Bad Nauheim, Germany

Location

Herz- und Diabeteszentrum Nordrhein-Westfalen

Bad Oeynhausen, Germany

Location

Segeberger Kliniken GmbH

Bad Segeberg, 23795, Germany

Location

Segeberger Kliniken

Bad Segeberg, Germany

Location

Caritas-Klinik Pankow

Berlin, Germany

Location

Charité - Universitätsmedizin Berlin - Campus Virchow-Klinikum

Berlin, Germany

Location

Charité - Universitätsmedizin Berlin-Campus Benjamin Franklin

Berlin, Germany

Location

Vivantes Klinikum Neukölln

Berlin, Germany

Location

Vivantes Klinikum Spandau

Berlin, Germany

Location

Vivantes-Klinikum Am Urban

Berlin, Germany

Location

Vivantesklinik im Friedrichshain

Berlin, Germany

Location

Immanuel Klinikum Bernau

Bernau, Germany

Location

Gesundheitszentrum Bitterfeld-Wolfen

Bitterfeld-Wolfen, Germany

Location

St. Josef- und Elisabeth- Hospital

Bochum, Germany

Location

Klinikum Links der Weser

Bremen, Germany

Location

Krankenhaus Buchholz

Buchholz, Germany

Location

Klinikum Coburg

Coburg, Germany

Location

Herzzentrum Universitätsklinikum Köln

Cologne, Germany

Location

Sana-Herzzentrum Cottbus

Cottbus, Germany

Location

Kardiovaskuläres Zentrum Darmstadt

Darmstadt, Germany

Location

Praxisklinik Herz und Gefässe Dresden

Dresden, Germany

Location

Werner-Forßmann-Krankenhaus

Eberswalde, Germany

Location

Kliniken Im Naturpark Altmühltal, Klinik Eichstätt

Eichstätt, Germany

Location

Universitätsklinikum Erlangen

Erlangen, Germany

Location

Alfried Krupp v. Bohlen Krankenhaus

Essen, Germany

Location

Elisabeth Krankenhaus Essen

Essen, Germany

Location

Universitätsklinikum Essen

Essen, Germany

Location

Universitätsklinikum Freiburg

Freiburg im Breisgau, Germany

Location

Klinikum Fulda

Fulda, Germany

Location

Main-Kinzig-Kliniken

Gelnhausen, Germany

Location

Universitätsklinikum Gießen

Giessen, 35392, Germany

Location

Universitätsklinikum Göttingen

Göttingen, Germany

Location

Universitätsklinikum Greifswald

Greifswald, Germany

Location

Asklepios Klinik Harburg

Hamburg, Germany

Location

Asklepios Klinik St. Georg

Hamburg, Germany

Location

Universitäres Herzzentrum Eppendorf

Hamburg, Germany

Location

Med. Hochschule Hannover

Hanover, Germany

Location

SLK-Kliniken Heilbronn

Heilbronn, Germany

Location

Oberhavel Kliniken-Klinik Hennigsdorf

Hennigsdorf, Germany

Location

Krankenhaus Herford

Herford, Germany

Location

Herz- und Gefäßzentrum Oberallgäu-Kempten

Immenstadt im Allgäu, Germany

Location

Klinikum Itzehoe

Itzehoe, Germany

Location

Herz- und Gefäßzentrum Oberallgäu/Kempten

Kempten, 87439, Germany

Location

Stiftungsklinikum Mittelrhein

Koblenz, Germany

Location

Universitätsklinikum Leipzig

Leipzig, Germany

Location

Klinikum Ludwigshafen

Ludwigshafen am Rhein, 67063, Germany

Location

Universitätsklinikum Schleswig Holstein

Lübeck, Germany

Location

Klinikum Lüdenscheid

Lüdenscheid, Germany

Location

St. Marien-Hospital

Lünen, Germany

Location

Universitätsklinikum Magdeburg

Magdeburg, Germany

Location

Universitätsklinikum Mainz

Mainz, Germany

Location

Universitätsklinikum Mannheim

Mannheim, Germany

Location

Universitätsklinikum Marburg

Marburg, Germany

Location

Krankenhaus St. Franziskus Mönchengladbach

Mönchengladbach, Germany

Location

Deutsches Herzzentrum München

Munich, Germany

Location

Isar Herz Zentrum München

Munich, Germany

Location

Klinikum der Universität München , Campus Großhadern

Munich, Germany

Location

Klinikum München-Bogenhausen

Munich, Germany

Location

Städtisches Klinikum München - Neuperlach

Munich, Germany

Location

Evangelisches Krankenhaus Mülheim

Mülheim, Germany

Location

Universitätsmedizin Rostock

Rostock, Germany

Location

GPR Klinikum Rüsselsheim

Rüsselsheim am Main, Germany

Location

St. Marien-Krankenhaus

Siegen, Germany

Location

Elbe Klinikum Stade

Stade, Germany

Location

SRH Zentralklinikum Suhl

Suhl, Germany

Location

Universitätsklinikum Ulm

Ulm, Germany

Location

St. Marienhospital

Vechta, Germany

Location

Schwarzwald-Baar Klinikum

Villingen-Schwenningen, Germany

Location

Rems-Murr-Klinik Winnenden

Winnenden, Germany

Location

Heinrich-Braun-Krankenhaus

Zwickau, Germany

Location

Related Publications (11)

  • Nef H, Wiebe J, Achenbach S, Munzel T, Naber C, Richardt G, Mehilli J, Wohrle J, Neumann T, Biermann J, Zahn R, Kastner J, Schmermund A, Pfannebecker T, Schneider S, Limbourg T, Hamm CW. Evaluation of the short- and long-term safety and therapy outcomes of the everolimus-eluting bioresorbable vascular scaffold system in patients with coronary artery stenosis: Rationale and design of the German-Austrian ABSORB RegIstRy (GABI-R). Cardiovasc Revasc Med. 2016 Jan-Feb;17(1):34-7. doi: 10.1016/j.carrev.2015.09.002. Epub 2015 Sep 10.

    PMID: 26431767BACKGROUND
  • Mehilli J, Achenbach S, Woehrle J, Baquet M, Riemer T, Muenzel T, Nef H, Naber C, Richardt G, Zahn R, Gori T, Neumann T, Kastner J, Schmermund A, Hamm C. Clinical restenosis and its predictors after implantation of everolimus-eluting bioresorbable vascular scaffolds: results from GABI-R. EuroIntervention. 2017 Dec 20;13(11):1319-1326. doi: 10.4244/EIJ-D-17-00291.

  • Nef HM, Wiebe J, Kastner J, Mehilli J, Muenzel T, Naber C, Neumann T, Richardt G, Schmermund A, Woehrle J, Zahn R, Riemer T, Achenbach S, Hamm CW. Everolimus-eluting bioresorbable scaffolds in patients with coronary artery disease: results from the German-Austrian ABSORB RegIstRy (GABI-R). EuroIntervention. 2017 Dec 20;13(11):1311-1318. doi: 10.4244/EIJ-D-17-00330.

  • Wohrle J, Nef HM, Naber C, Achenbach S, Riemer T, Mehilli J, Munzel T, Schneider S, Markovic S, Seeger J, Rottbauer W, Pfannebecker T, Richardt G, Zahn R, Gori T, Kastner J, Schmermund A, Hamm CW; GABI-R Study Group. Predictors of early scaffold thrombosis: results from the multicenter prospective German-Austrian ABSORB RegIstRy. Coron Artery Dis. 2018 Aug;29(5):389-396. doi: 10.1097/MCA.0000000000000618.

  • Huseynov A, Baumann S, Nef H, Riemer T, Schneider S, Pfannenbecker T, Achenbach S, Mehilli J, Munzel T, Gori T, Wohrle J, Zahn R, Kastner J, Schmermund A, Richardt G, Hamm CW, Akin I. Comparison between treatment of "established" versus complex "off-label" coronary lesions with Absorb(R) bioresorbable scaffold implantation: results from the GABI-R(R) registry. Clin Res Cardiol. 2020 Mar;109(3):374-384. doi: 10.1007/s00392-019-01517-8. Epub 2019 Jun 29.

  • Hemetsberger R, Abdelghani M, Mankerious N, Allali A, Toelg R, Gori T, Achenbach S, Riemer T, Mehilli J, Nef HM, Naber C, Wohrle J, Zahn R, Kastner J, Schmermund A, Hamm C, Munzel T, Richardt G; GABI-R Study Group. Impact of coronary calcification on outcomes after ABSORB scaffold implantation: insights from the GABI-R registry. Coron Artery Dis. 2020 Nov;31(7):578-585. doi: 10.1097/MCA.0000000000000870.

  • Gori T, Achenbach S, Riemer T, Mehilli J, Nef HM, Naber C, Richardt G, Wohrle J, Zahn R, Neumann T, Kastner J, Schmermund A, Hamm C, Munzel T. Hybrid Coronary Percutaneous Treatment with Metallic Stents and Everolimus-Eluting Bioresorbable Vascular Scaffolds: 2-years Results from the GABI-R Registry. J Clin Med. 2019 May 30;8(6):767. doi: 10.3390/jcm8060767.

  • Pahmeier K, Neusser S, Hamm C, Kastner J, Wohrle J, Zahn R, Achenbach S, Mehilli J, Gori T, Naber C, Nef H, Neumann T, Richardt G, Schmermund A, Claas C, Riemer T, Biermann-Stallwitz J; GABI-R Study Group. Quality of life of patients with coronary heart disease treated with the bioresorbable vascular scaffold (ABSORB): 2-year results from the GABI-R-registry. BMC Cardiovasc Disord. 2022 Aug 20;22(1):379. doi: 10.1186/s12872-022-02815-2.

  • Wein B, Zaczkiewicz M, Graf M, Zimmermann O, Gori T, Nef HM, Kastner J, Mehilli J, Richardt G, Wohrle J, Achenbach S, Riemer T, Hamm C, Torzewski J. No Difference in 30-Day Outcome and Quality of Life in Transradial Versus Transfemoral Access - Results From the German Austrian ABSORB Registry (GABI-R). Cardiovasc Revasc Med. 2022 Jul;40:144-149. doi: 10.1016/j.carrev.2021.11.022. Epub 2021 Nov 24.

  • Boeder NF, Kastner J, Mehilli J, Munzel T, Naber C, Neumann T, Richardt G, Schmermund A, Wohrle J, Zahn R, Riemer T, Achenbach S, Hamm CW, Nef HM; GABI-R Study Group. Predictors of scaffold failure and impact of optimized scaffold implantation technique on outcome: Results from the German-Austrian ABSORB RegIstRy. Catheter Cardiovasc Interv. 2021 Oct;98(4):E555-E563. doi: 10.1002/ccd.29829. Epub 2021 Jun 18.

  • Zaczkiewicz M, Wein B, Graf M, Zimmermann O, Kastner J, Wohrle J, Thomas R, Hamm C, Torzewski J; GABI-R Study Group. Two year efficacy and safety of small versus large ABSORB bioresorbable vascular scaffolds of </=18 mm device length: A subgroup analysis of the German-Austrian ABSORB RegIstRy (GABI-R). Int J Cardiol Heart Vasc. 2020 Mar 20;27:100501. doi: 10.1016/j.ijcha.2020.100501. eCollection 2020 Apr.

MeSH Terms

Conditions

Coronary Stenosis

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular Diseases

Study Officials

  • Christian Hamm, Prof. Dr.

    University Clinic Giessen and Kerckhoff-Clinic Bad Nauheim

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Target Duration
5 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 20, 2014

First Posted

February 19, 2014

Study Start

November 8, 2013

Primary Completion

January 31, 2016

Study Completion

July 6, 2021

Last Updated

April 1, 2022

Record last verified: 2021-07

Locations