the Application of Cardiopulmonary Exercise Testing in Assessment Outcome of Patients With Pulmonary Hypertension

NCT02061787 | Recruiting

• 1 other identifier: CPETPH
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

cardiopulmonary exercise test evaluate patients with pulmonary hypertension before and after medical or balloon pulmonary angioplasty treatment

Conditions

Pulmonary Hypertension; Chronic Thromboembolic Pulmonary Hypertension; Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder)

Keywords

Chronic Thromboembolic Pulmonary Hypertension; Pulmonary Arterial Hypertension; balloon pulmonary angioplasty; cardiopulmonary exercise test

Outcome Measures

Primary Outcomes (3)

• all cause mortality

  all cause mortality

  5 years

• mean pulmonary arterial pressure after treatment

  the mean pulmonary arterial pressure of patients with chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty treatment

  5 years

• achievement of low risk

  patients with chronic thromboembolic pulmonary hypertension achievement of low risk after balloon pulmonary angioplasty

  5 years

Secondary Outcomes (1)

• deterioration of WHO function

  5 years

Study Arms (1)

cardiopulmonary exercise testing

patients diagnosed with pulmonary hypertension, including pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension, were evaluated by cardiopulmonary exercise testing before and after medical or balloon pulmonary angioplasty treatment

Device: balloon pulmonary angioplasty

Interventions

balloon pulmonary angioplasty DEVICE

patients with chronic thromboembolic pulmonary hypertension who underwent balloon pulmonary angioplasty

cardiopulmonary exercise testing

Eligibility Criteria

• Age: 5 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

pulmonary hypertension who may accomplish cardiopulmonary exercise testing.

You may qualify if:

• pulmonary arterial hypertension;( WHO1)
• chronic thromboembolic pulmonary hypertension;
• pulmonary arterial hypertension due to other cause;

You may not qualify if:

• massive hemoptysis;
• unable to accomplish cardiopulmonary exercise testing due to neuromuscular disorders;
• recent recurrent syncope;
• pulmonary hypertension due to hypoxia;
• pulmonary hypertension due to left heart diseases.

Sponsors & Collaborators

• Chinese Pulmonary Vascular Disease Research Group: lead

Study Sites (1)

center of pulmonary vascular disease, Fuwai hospital

Beijing, 100037, China

RECRUITING

Related Publications (2)

• Li X, Duan A, Jin Q, Zhang Y, Luo Q, Zhao Q, Yan L, Huang Z, Hu M, Xiong C, Zhao Z, Liu Z. Exercise feature and predictor of prognosis in patients with pulmonary artery stenosis-associated pulmonary hypertension. ESC Heart Fail. 2022 Dec;9(6):4198-4208. doi: 10.1002/ehf2.14154. Epub 2022 Sep 13.

  PMID: 36101502 DERIVED

• Tang Y, Yao L, Liu Z, Ma X, Luo Q, Zhao Z, Huang Z, Tu L, Gao L, Jin Q, Ni X, Xiong C. Effect of calcium channel blockers evaluated by cardiopulmonary exercise testing in idiopathic pulmonary arterial hypertension responding to acute pulmonary vasoreactivity testing. Pulm Pharmacol Ther. 2017 Apr;43:26-31. doi: 10.1016/j.pupt.2017.01.012. Epub 2017 Feb 1.

  PMID: 28159512 DERIVED

MeSH Terms

Conditions

Hypertension, Pulmonary; Pulmonary Arterial Hypertension

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Zhihong Liu, MD，PhD

  Fuwai Hospital, National Center for Cardiovascular Diseases

  STUDY DIRECTOR

Central Study Contacts

Zhihong Liu, Doctor

CONTACT

8601088396590; zhihongliufuwai@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 11, 2014
• First Posted: February 13, 2014
• Study Start: September 1, 2010
• Primary Completion (Estimated): September 8, 2030
• Study Completion (Estimated): September 8, 2030
• Last Updated: September 19, 2024

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)