Mindfulness Based Compassionate Living in Recurrent Depression
MBCL-RD
The Effectiveness of Mindfulness Based Compassionate Living in Recurrent Depression
1 other identifier
interventional
122
1 country
1
Brief Summary
Since a few years, Mindfulness Based Cognitive Therapy (MBCT) has been used as treatment for patients suffering from recurrent depression. Though a number of studies show that MBCT is effective in this population and MBCT reduces the chances of relapse/recurrence in recurrent depressive patients, the chance of a new depression developing after end of treatment is still considerable. Ergo, there is room for improvement. Especially the development of a non-judging or compassionate attitude towards all experience seems to mediate the treatment effect. It is therefore our expectation that a follow-up intervention that focuses specifically on self-compassion could prove very useful in elaborating on the effects of MBCT. The research question of this research is therefore: what is the effect of compassion training in people suffering from recurrent depression who have already received MBCT training?
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jul 2013
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2013
CompletedFirst Submitted
Initial submission to the registry
January 30, 2014
CompletedFirst Posted
Study publicly available on registry
February 11, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2015
CompletedApril 18, 2023
April 1, 2023
1.8 years
January 30, 2014
April 14, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Beck Depression Inventory-II
The BDI-II measures depression symptoms. Measurements will be taken at baseline, end of treatment/control and follow up.
1 year
Secondary Outcomes (8)
Self-Compassion Scale
1 year
Five Facet Mindfulness Questionnaire
1 year
The Acceptance and Action Questionnaire-II
1 year
Fears of Compassion Scale (3)
1 year
Types of Positive Affect Scale
1 year
- +3 more secondary outcomes
Study Arms (2)
MBCL + TAU
EXPERIMENTALThis cohort receives the Mindfulness Based Compassionate Living program in addition to treatment as usual.
TAU
NO INTERVENTIONThis cohort receives treatment as usual of any nature, e.g. psychotherapy, antidepressant medication etc.
Interventions
The MBCL program consists of eight biweekly group sessions of 2.5 hours, in which the participants get formal meditation exercises, some theoretical information and participate in inquiry on the meditation exercises and homework assignments. Homework assignments are given after every session, consisting of formal and informal meditation exercises primarily and some diary instructions.
Eligibility Criteria
You may qualify if:
- Recurrent depression according to the DSM-IV criteria.
- Having participated in an MBCT training (\>= 4 sessions)
You may not qualify if:
- One or more previous (hypo)manic episodes according to DSM-IV criteria.
- Primary psychotic disorder, e.g. schizophrenia or delusions.
- Clinically relevant neurological conditions (e.g. brain trauma or dementia) or somatic conditions (e.g. cancer, AIDS) that could be related to the depression.
- Current alcohol and/or drug abuse.
- Use of high dosages of benzodiazepines.
- Recent electro convulsive therapy (ECT) (less than 3 months ago).
- Problems impeding participating in a group, such as severe borderline personality disorder.
- No prior experience with MBCT.
- Problems impeding completing the questionnaires, such as cognitive dysfunctions (only assessed if suspected).
- Subnormal intelligence (IQ \< 80) (only assessed if suspected).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Radboud University Medical Centerlead
- Triodos Foundationcollaborator
Study Sites (1)
University Medical Center Nijmegen
Nijmegen, Gelderland, Netherlands
Related Publications (2)
Schuling R, Huijbers MJ, van Ravesteijn H, Donders R, Cillessen L, Kuyken W, Speckens AEM. Recovery from recurrent depression: Randomized controlled trial of the efficacy of mindfulness-based compassionate living compared with treatment-as-usual on depressive symptoms and its consolidation at longer term follow-up. J Affect Disord. 2020 Aug 1;273:265-273. doi: 10.1016/j.jad.2020.03.182. Epub 2020 May 4.
PMID: 32421612DERIVEDSchuling R, Huijbers MJ, van Ravesteijn H, Donders R, Kuyken W, Speckens AE. A parallel-group, randomized controlled trial into the effectiveness of Mindfulness-Based Compassionate Living (MBCL) compared to treatment-as-usual in recurrent depression: Trial design and protocol. Contemp Clin Trials. 2016 Sep;50:77-83. doi: 10.1016/j.cct.2016.07.014. Epub 2016 Jul 21.
PMID: 27451354DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Anne Speckens, Professor
University Medical Center Nijmegen
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
January 30, 2014
First Posted
February 11, 2014
Study Start
July 1, 2013
Primary Completion
May 1, 2015
Study Completion
November 1, 2015
Last Updated
April 18, 2023
Record last verified: 2023-04