Cognitive Remediation of Autobiographical Memory in Schizophrenia Using SenseCam®

NCT02038465 | Unknown

• 1 other identifier: 5539
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to assess the efficiency of SenseCam® in patients with schizophrenia by comparing two cognitive remediation methods of autobiographical memory.Patients and control participants will be invited to carry SenseCam® during 7 hours per day minimum and for 4 successive days. Each ending day when carry SenseCam®, they will be asked to go to the laboratory where 4 types of interventions will be successively done according to the randomization: 1) a simple visual retrospective procedure (SVR), 2) a visual retrospective procedure coupled with a specific cueing intervention (VR-SC), 3) a verbal retrospective (VbR) and 4) no intervention (control condition).The testing phase will take place 14 days after the last day of data collection and will consist in a cued recall task and a recognition task using the pictures obtained by the SenseCam® of the participants.According to our hypotheses, the vividness of memories will be higher in events subjected to the VR-SC procedure than in events subjected to the SVR and VbR procedures. This effect is expected for both patients with schizophrenia and controls participants. Since strategies to enrich memory details will be explicitly given to the patients when using the VR-SC procedure, we assume that patients will be able to normalize their scores.

Conditions

Schizophrenia Cognition Autobiographical Memory Cognitive Remediation

Outcome Measures

Primary Outcomes (1)

• Specificity of memories recovered by using the SenseCam camera during the trial

  Test the effectiveness of two techniques of cognitive remediation of autobiographical memory using an innovative tool called SenseCam.This specificity will be evaluated by the experimenter by scoring wealth in detail memories reported during the cued recall task

  1 month

Study Arms (2)

patient

OTHER

Complete questionary remembering the day

Device: Questionary

healthy volunteers

OTHER

\- Complete questionary, remembering the day

Device: Questionary

Interventions

Questionary DEVICE

Test the effectiveness of two techniques of cognitive remediation of autobiographical memory using an innovative tool called SenseCam ® for patient

healthy volunteers; patient

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• for both patients and controls
• male or female willing to participate and who have signed up the legal document
• under the protection of health insurancefor patients only
• schizophrenia or schizo-affective disorder according to the DSM-IV
• TR criteria
• clinically stable for at least 2 monthsfor controls only
• no psychiatric history

You may not qualify if:

• for both patients and controls
• current severe or unstable somatic illness
• neurological history (epilepsia, brain injury, brain surgery…)
• current substance use disorder (DSM-IV-TR)
• current major depressive disorder (DSM-IV-TR)
• mental retardation (IQ \< 70)
• pregnancy, breast feeding
• current legal controlfor patients only
• treatment comprising benzodiazepines
• benzodiazepines intake during the last 3 weeksfor controls only
• psychotropic intake during the last 3 weeks

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Berna

Strasbourg, 67000, France

RECRUITING

Study Officials

• Fabrice Berna, MD

  Les Hôpitaux Universitaires de Strasbourg

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fabrice Berna, MD

CONTACT

fabrice.berna@chru-strasbourg.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 25, 2013
• First Posted: January 16, 2014
• Study Start: May 1, 2014
• Primary Completion: September 1, 2019
• Study Completion: December 1, 2019
• Last Updated: August 28, 2018

Record last verified: 2018-08

Locations

FR (1)