Phase I/II Trial of Rhenium 188-P2045 in Small Cell Lung Cancer and Other Advanced Neuroendocrine Carcinomas

NCT02030184 | Withdrawn Phase 1 DMC FDA Drug

• 1 other identifier: INST 1401
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

There are two parts to this trial. The first study will evaluate increasing doses of Re188 P2045 in patients with advanced small cell lung cancer that has recurred after initial therapy or in patients with other advanced neuroendocrine cancers that have progressed after therapy. Re188 P2045 is designed to attach to type 2 somatostatin receptors that are frequently expressed in those cancers and then the radioactivity from Re188 will kill the cancer cell. Only patients who have cancers that can be seen when Tc99 P2045 is administered (also seeks out the SSTR2, but Tc99 images, but does not treat the cells) will be treated. Therefore, this approach maximizes the possibility that patients will benefit from treatment in that only those who have cancers that have the target will undergo treatment. The primary purpose of this study will be to determine the highest dose of Re188 P2045 that can be safely administered. The second study will open after the conclusion of the first. Patients will first undergo the scan with Tc99 P2045 and then be treated with topotecan for three days. Topotecan is a standard chemotherapy drug that is approved for second line therapy for small cell and frequently used for other neuroendocrine cancers. Following that, patients will then be re-evaluated with the Tc99 P2045 scan and if it demonstrates that the tumor is positive for SSTR2, then patients will receive Re188 P2045. The goal of this study is to determine the highest dose of Re188 P2045 that can be safely administered after topotecan as well as to determine if topotecan will increase the chance that the tumor will express SSTR2.

Conditions

Small Cell Lung Cancer (SCLC); Neuroendocrine (NE) Tumors; Large Cell Neuroendocrine (NE) Tumors

Keywords

Lung cancer; Small cell lung cancer; Neuroendocrine tumor; Rhenium; Re 188-P2045

Outcome Measures

Primary Outcomes (1)

• Determine Maximum Tolerated Dose (MTD)

  To determine, via dose-limiting toxicity (DLT), the maximally tolerated dose (MTD) for Rhenium Re188-P2045 when administered as a single dose in patients with advanced neuroendocrine tumors and SSTR2 expression as determined by Tc99m P2045 scanning.

  28 days

Secondary Outcomes (4)

• Overall Response Rate (ORR)

  5 Years

• Progression Free Survival (PFS) Rate

  5 years

• Change in SSTR2 Expression

  3 Days

• Correlation: Pre-therapy SSTR2 Expression vs. ORR and PFS

  5 years

Study Arms (1)

Topotecan and Rhenium Re 188 P2045

EXPERIMENTAL

In the phase II portion of this study, patients will be screened using Technicium Tc99m. Eligible, consented patients will receive Topotecan treatment for three days, at doses of either 1.0 mg/m2 or 1.5 mg/m2. They will then receive a single dose of Rhenium Re 188-P2045, at one of the following dosage levels based on the Phase I Maximum Tolerated Dose (MTD): 40% of MTD; 50% of MTD; 75% of MTD; 85% of MTD or 100% of MTD.

Drug: Rhenium Re 188-P2045

Interventions

Rhenium Re 188-P2045 DRUG

Topotecan at 1.0 mg/m2 or 1.5 mg/m2 for 3 days, followed by single dose of Rhenium Re 188-P2045, at one of the following dosage levels based on the Phase I Maximum Tolerated Dose (MTD): 40% of MTD; 50% of MTD; 75% of MTD; 85% of MTD or 100% of MTD.

Also known as: Study B

Topotecan and Rhenium Re 188 P2045

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \>/=18 years.
• Advanced, metastatic or locally recurrent, incurable neuroendocrine tumors (small cell lung cancer, extrapulmonary small cell lung cancer, large cell neuroendocrine lung carcinoma pulmonary carcinoid, GI carcinoid tumor
• Symptomatic CNS metastases: must have received therapy (surgery, XRT, gamma knife)
• Asymptomatic CNS metastatic disease: discuss with Study Chair.
• Histologically-or cytologically documented disease.
• Considered incurable by any combination of therapy including surgery, radiation, chemotherapy.
• ECOG Performance status 0-2
• Renal function: creatinine clearance \> 40 mg/mlxmin (Cockroft-Gault)
• Adequate organ and marrow function by:
• Absolute neutrophil count (ANC) \>/=1,500/mcL.
• Platelets \>/= 100,000/mcL.
• Total bilirubin within normal institutional limits (WNL)
• AST (SGOT)/ALT (SPGT) \</= 2.5 x upper limit of normal (ULN)
• Women (child-bearing potential) and men must use adequate contraception prior to study entry, for duration of study participation, and 90 days after completion of therapy.
• A female of child-bearing potential is any woman is one who has not undergone a hysterectomy or bilateral oophorectomy; or

You may not qualify if:

• Merkel cell carcinoma
• Leptomeningeal disease or carcinomatous meningitis
• Chemotherapy or radiotherapy within 3 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered \> 3 weeks earlier.
• If the patient was receiving an oral agent, at least 4 half lives should have elapsed.
• Cannot receive any other investigational agent at the time of registration. At least 3 weeks should have elapsed since administration of an IV investigational agent or 4 half lives for an oral investigational agent.
• At least 28 days should have elapsed since administration of a long acting somatostatin analogue.
• Patients with known brain metastases are eligible (see criteria above). Leptomeningeal metastases are not eligible.
• Patients who have received external beam radiation to more than 20% of marrow.
• No prior radiation to the kidneys.
• Prior systemic radiotherapy are not eligible (except for prior I131 for thyroid cancer more than 1 year earlier).
• Receiving long term immunosuppressive medications for rheumatologic or other disease (e.g. low dose methotrexate, mecaptopurine etc).
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to octreotide or other somatostatin analogues.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Pregnant or nursing (due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.)

Sponsors & Collaborators

• University of Maryland, Baltimore: lead

Study Sites (1)

University of Maryland Marlene & Stewart Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

Location

MeSH Terms

Conditions

Small Cell Lung Carcinoma; Neoplasms; Lung Neoplasms; Neuroendocrine Tumors

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Lung Diseases; Respiratory Tract Diseases; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms, Nerve Tissue

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 6, 2014
• First Posted: January 8, 2014
• Study Start: June 1, 2017
• Primary Completion: June 1, 2019
• Study Completion: June 1, 2021
• Last Updated: October 17, 2019

Record last verified: 2019-10

Locations

US (1)