NCT02027467

Brief Summary

Combination of various herbs is known to promote mobilization of hematopoietic stem cells. Hence the current study has been intended to study the effect of Stem Alive® on mobilization of stem cells. Stem Alive® include ingredients like green tea, ashwagandha, etc which are known to be used as traditional medicine. They are also tested qualitatively in academic and nutritional science research centers throughout the world and which substantially according to those studies stimulate the augmented availability of circulating hematopoietic cells. This study is projected to investigate the mobilization of stem cells on healthy human volunteers.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
23

participants targeted

Target at P25-P50 for not_applicable healthy

Timeline
Completed

Started Feb 2014

Shorter than P25 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 18, 2013

Completed
2 months until next milestone

First Posted

Study publicly available on registry

January 6, 2014

Completed
26 days until next milestone

Study Start

First participant enrolled

February 1, 2014

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2014

Completed
Last Updated

May 6, 2014

Status Verified

May 1, 2014

Enrollment Period

2 months

First QC Date

November 18, 2013

Last Update Submit

May 3, 2014

Conditions

Keywords

Hematopoietic stem cellsHerbalDietaryCD cellsBasic research

Outcome Measures

Primary Outcomes (3)

  • CD34+

    Day 0, Day 1, Day 2, Day 7, Day 12 and Day 14

  • CD45+

    Day 0, Day 1, Day 2, Day 7, Day 12 and Day 14

  • CD133+

    Day 0, Day 1, Day 2, Day 7, Day 12 and Day 14

Study Arms (2)

StemAlive®

EXPERIMENTAL

Stem Alive® includes ingredients like green tea, ashwagandha. Dose: 3 capsules twice daily to be taken orally for 14 days.

Dietary Supplement: StemAlive®

Placebo

PLACEBO COMPARATOR

Matching placebo capsules (for StemAlive®) containing polyethylene glycol, rice powder and magnesium stearate. Dose: 3 capsules twice daily to be taken orally for 14 days.

Dietary Supplement: Placebo (For StemAlive®)

Interventions

StemAlive®DIETARY_SUPPLEMENT
StemAlive®
Placebo (For StemAlive®)DIETARY_SUPPLEMENT
Placebo

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy Male and Female Volunteers
  • Willing to sign Informed Consent Form

You may not qualify if:

  • Anemia
  • SGOT and Serum Creatinine values twice the upper limit of normal
  • Volunteers who smoke / consume alcohol / take recreational drugs
  • Fever or Flu in the last one week of screening
  • History of Gastric or Duodenal Ulcer
  • Volunteers on vitamins, nutritional or herbal products since last one month
  • Pregnant, Breast feeding and Lactating women
  • Volunteers taking antibiotic, NSAIDS, anti-inflammatory within last 7 days
  • Allergic to ingredients of test product
  • Any co morbid or systemic condition or immunocompromised state making volunteer unfit for participation.
  • Volunteers deemed unfit for the study by the Investigator

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dhanwantari Clinic

Mumbai, Maharashtra, 400072, India

Location

Study Officials

  • Sandip Patil, MD

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 18, 2013

First Posted

January 6, 2014

Study Start

February 1, 2014

Primary Completion

April 1, 2014

Study Completion

April 1, 2014

Last Updated

May 6, 2014

Record last verified: 2014-05

Locations