Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects
AFC-SPICES
Investigation on Effect of Herbs and Spices on Glucose and Insulin Responses, Anti-inflammatory Properties, Antioxidative Capacity and Satiety in Healthy Subjects
1 other identifier
interventional
21
1 country
1
Brief Summary
The purpose of the study is to investigate how herbs and spices affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite ratings (VAS-visual analogue scales) in healthy volunteers. We hypothesize that certain herbs and spices added to a standardized meal will improve postprandial glucose tolerance and other metabolic biomarkers in healthy volunteers, compared with a similar meal without the corresponding plant materials.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable healthy
Started Mar 2014
Shorter than P25 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 10, 2014
CompletedFirst Posted
Study publicly available on registry
January 14, 2014
CompletedStudy Start
First participant enrolled
March 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2014
CompletedAugust 27, 2018
August 1, 2018
3 months
January 10, 2014
August 23, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Changing on blood glucose concentration after treatment with herbs and spices
The capillary blood samples will be taken for blood glucose analysis
Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.
Secondary Outcomes (4)
Changing on subjective appetite ratings after treatment with herbs and spices
Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.
Changing on metabolic biomarkers after treatment with herbs and spices
Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.
Changing on urine metabolite profile after treatment with herbs and spices
Prior to the initial intervention at 0 min and up to 24-h after intervention
Changing on plasma metabolite profile after treatment with herbs and spices
Prior to the initial intervention at 0 min and after intervention at 60, 90, 120, 180 min.
Study Arms (6)
Spices 1
EXPERIMENTAL220 ml test drink containing spices 1, acute study / one time administration
Spices 2
EXPERIMENTAL220 ml test drink containing spices 2, acute study / one time administration
Spices 3
EXPERIMENTAL220 ml test drink containing spices 3, acute study / one time administration
Herbs 1
EXPERIMENTAL220 ml test drink containing herbs 1, acute study / one time administration
Herbs 2
EXPERIMENTAL220 ml test drink containing herbs 2, acute study / one time administration
Placebo
PLACEBO COMPARATOR220 ml control drink, acute study / one time administration
Interventions
In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of spices 1. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate.
In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of spices 2. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate.
In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of spices 3. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate.
In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of herbs 1. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate.
In this study, subjects are asked to consume 200 ml beverage drinks contain certain amounts of herbs 2. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate.
As a control, subjects are asked to consume 200 ml control drinks. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate.
Eligibility Criteria
You may qualify if:
- Healthy males and females
- Signed informed consent
- BMI 20 - 28 kg/m2 with weight change \<3 kg latest 2 months)
- Must be able to accept herbs and spices
You may not qualify if:
- Below 18 years
- Uncomfortable speaking English and/or difficulties in understanding spoken English
- Smoking or using snuff
- Vegetarian or vegan
- Stressed by venous blood sampling or previous experience of being difficult to cannulate
- Receiving any drug treatment that may influence the study outcomes
- Pregnancy or breastfeeding
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Lund Universitylead
- Anti-Diabetic Food Centrecollaborator
Study Sites (1)
Antidiabetic Food Centre (Medicon Village) - Lund University
Lund, Skåne County, 22381, Sweden
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Elin Östman, PhD
Lund University
- PRINCIPAL INVESTIGATOR
Yoghatama Cindya Zanzer, MSc
Lund University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assoc. Prof, PhD
Study Record Dates
First Submitted
January 10, 2014
First Posted
January 14, 2014
Study Start
March 1, 2014
Primary Completion
June 1, 2014
Study Completion
June 1, 2014
Last Updated
August 27, 2018
Record last verified: 2018-08