Internet-delivered Attention Training for Obsessive-Compulsive Disorder

NCT02018848 | Completed

• 1 other identifier: HU-ATP-OCD-2013
• Study Type: interventional
• Target: 108
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to investigate an attention training program for participants with Obsessive-Compulsive Disorder. The attention training consists of a modified dot probe task with picture stimuli related to washing and checking paired with neutral pictures. Participants are randomly assigned to an experimental and a placebo-control group. After a minimum of 4 weeks of attention training we expect to find differences between participants of the experimental and the control group in terms of attention bias, OCD symptoms, anxiety and depression.

Conditions

Obsessive-Compulsive Disorder

Keywords

Obsessive-Compulsive Disorder; Attention Training; Attention Bias Modification; Dot-Probe Task; Randomized Controlled Trial; Online Treatment; Washing; Checking

Outcome Measures

Primary Outcomes (3)

• Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T1

  The Y-BOCS-SRS measures severity of OCD symptoms.

  pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set)

• Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T2

  The Y-BOCS-SRS measures severity of OCD symptoms.

  post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)

• Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T3

  The Y-BOCS-SRS measures severity of OCD symptoms.

  follow-up, between day 27 and 50 after T2 questionnaires (time limit set)

Secondary Outcomes (3)

• Obsessive-Compulsive Inventory-Revised (OCI-R) T1

  pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set)

• Obsessive-Compulsive Inventory-Revised (OCI-R) T2

  post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)

• Obsessive-Compulsive Inventory-Revised (OCI-R) T3

  follow-up, between day 27 and 50 after T2 questionnaires (time limit set)

Other Outcomes (8)

• Beck Anxiety Inventory (BAI) T1

  pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set, all further steps relative to exact time point of T1 questionnaires)

• Beck Anxiety Inventory (BAI) T2

  post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)

• Beck Anxiety Inventory (BAI) T3

  follow-up, between day 27 and 50 after T2 questionnaires (time limit set)

Study Arms (2)

Attention Training Placebo

PLACEBO COMPARATOR

Same procedure, stimulus material, frequency and duration as in experimental group. The only difference: In the placebo group the probe randomly appears at one of the two locations on the screen so as not to train attention in any direction. Thus, the placebo training sessions are identical to the bias assessment sessions.

Attention Training Program

EXPERIMENTAL

The Attention Training consists of a modified dot-probe task. In this task pairs of pictures (OCD-relevant/neutral) are presented for 500 ms on a computer screen. Next, a probe appears on one of the two former picture locations. Participants have to react to that probe by pressing the corresponding button on the keyboard. One training session takes approximately 10 minutes in which 160 stimulus pairs are shown. In the experimental group the probe always appears at the location of the neutral picture so as to train attention away from OCD-relevant stimuli. Participants are asked to complete at least 2 training sessions per week over a period of 5 weeks. The first and last session are bias assessment sessions (see outcome measures), but participants stay blind to this.

Behavioral: Attention Training Program

Interventions

Attention Training Program BEHAVIORAL

Also known as: ATP, Attention Bias Modification Treatment, ABMT, Bias Modification, Attentional Training

Attention Training Program

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of primary OCD according to OCI-R self report (cut-off \>=18)

You may not qualify if:

• suicidal
• substance abuse or addiction
• psychotic symptoms
• visual impairment if not compensated with optical aid

Sponsors & Collaborators

• Humboldt-Universität zu Berlin: lead

Study Sites (1)

Humboldt-Universität zu Berlin

Berlin, State of Berlin, 10099, Germany

Location

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Interventions

Adenosine Triphosphate

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Adenine Nucleotides; Purine Nucleotides; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Nucleotides; Nucleic Acids, Nucleotides, and Nucleosides; Ribonucleotides

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. phil. Dipl. Psych.

Study Record Dates

• First Submitted: November 28, 2013
• First Posted: December 23, 2013
• Study Start: October 1, 2013
• Primary Completion: July 1, 2014
• Study Completion: July 1, 2014
• Last Updated: November 13, 2014

Record last verified: 2014-11

Locations

DE (1)