Effect of Different Types of Carbohydrates Consumed After Exercise on Blood Fat Levels

NCT02012855 | Completed

• 1 other identifier: 000041
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The increase in fat (i.e. triglyceride) in the blood after a meal is a well-established risk factor for heart disease (Nordestgaard et al. 2007). Endurance exercise is beneficial for improving the blood lipid response to a subsequent meal; that is, the appearance of fat (triglyceride) in the blood is less after a meal if endurance exercise was performed shortly before (i.e. within half a day) of the meal (Petit et al. 2003). This benefit of exercise is unfortunately negated if the after-exercise food choice to replace the calories expended during exercise is one containing high glycemic index carbohydrates. For example, if a high glycemic index carbohydrate is consumed after an evening exercise session, the exercise no longer has an effect of lowering triglyceride in the blood after a meal consumed the next morning (Harrison et al. 2009; Burton et al. 2008). Very rarely do people perform an exercise session and then fast until their next meal hours later. The more common practice is to consume food immediately after the exercise to enhance recovery and because hunger is stimulated with exercise. Consuming carbohydrate with a low glycemic index has been shown to reduce the level of fat in the blood following a subsequent meal (Gruendel et al. 2007). To date, no studies have examined the effects of consuming a low-glycemic index meal after exercise on the blood fat response to a subsequent meal. The specific objective of our research is to determine the effect of consuming low glycemic index lentils after an endurance exercise session on the blood fat (triglyceride) response to a subsequent meal. Twenty-five overweight or obese men will have their blood triglycerides measured four times over six hours after a high-fat morning meal following four different conditions, in a randomized, counterbalanced, cross-over design (i.e. the 25 subjects will each participate in all four conditions, where the order of conditions for each person is randomized): 1) After exercise (90 minutes of moderate intensity walking) is performed the evening before, followed by caloric replacement with a high-glycemic index meal (i.e. white bread and instant mashed potatoes); 2) After the same exercise is performed the evening before, followed by caloric replacement with a lentil-based meal; 3) After the same exercise is performed the evening before, followed by fasting; 4) After a no exercise/ no meal condition (i.e. control condition). In addition to measuring blood triglycerides we will measure blood insulin, free fatty acid, high density lipoproteins, low density lipoproteins, and glucose levels as these are also related to cardiovascular disease risk and may be altered with exercise and lentil consumption. We will also measure the muscle's ability to burn fat (i.e. fat oxidation) by assessing respiratory gases (oxygen consumption and carbon dioxide output) after the high-fat meal because we expect exercise and lentils to increase fat oxidation. Our expected results are that consuming lentils after endurance exercise will lower the blood triglyceride response to a subsequent meal compared to exercise alone or when high-glycemic index carbohydrates are consumed after the exercise.

Conditions

Hyperlipidemia

Outcome Measures

Primary Outcomes (1)

• Change in blood triglycerides

  Change from baseline at 6 hours

Secondary Outcomes (6)

• Change in blood glucose

  Change from baseline at 6 hours

• Change in fat oxidation

  Change from baseline at 6 hours

• Change in low density lipoproteins

  Change from baseline at 6 hours

• Change in high density lipoproteins

  Change from baseline at 6 hours

• Change in total cholesterol

  Change from baseline at 6 hours

Study Arms (4)

Exercise only

EXPERIMENTAL

90 minutes of exercise

Behavioral: Exercise

Exercise and high glycemic index meal

EXPERIMENTAL

90 minutes of exercise followed by a high glycemic index meal matched for calories expended during the exercise

Behavioral: Exercise; Other: Diet (meal type)

Exercise and low glycemic index meal

EXPERIMENTAL

90 minutes of exercise followed by a low glycemic index meal matched for calories expended during the exercise

Behavioral: Exercise; Other: Diet (meal type)

No exercise and no meal

NO INTERVENTION

No exercise and no meal

Interventions

Exercise BEHAVIORAL

Exercise and high glycemic index meal; Exercise and low glycemic index meal; Exercise only

Diet (meal type) OTHER

Exercise and high glycemic index meal; Exercise and low glycemic index meal

Eligibility Criteria

• Age: 18 Years - 44 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body mass index of 25 or greater
• years of age

You may not qualify if:

• diabetics
• smokers
• those taking medications for cholesterol or glucose

Sponsors & Collaborators

• University of Saskatchewan: lead
• Heart and Stroke Foundation of Canada: collaborator

Study Sites (1)

University of Saskatchewan

Saskatoon, Saskatchewan, S7N 5B2, Canada

Location

MeSH Terms

Conditions

Hyperlipidemias

Interventions

Exercise; Diet

Condition Hierarchy (Ancestors)

Dyslipidemias; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Philip D Chilibeck, Ph.D.

  University of Saskatchewan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ph.D.

Study Record Dates

• First Submitted: August 15, 2013
• First Posted: December 16, 2013
• Study Start: August 1, 2013
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: May 5, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)