What is in Fact the Contribution of Reducing Time Spent in Sedentary Behaviors on Daily Energy Expenditure? A Doubly Labeled Water Study

NCT02007681 | Completed DMC

• 1 other identifier: CEFMH || Parecer 14/2013
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The main purposes of this randomized cross-over trial are to test if a 3h/day reduction of time spent in sedentary behaviour (SB) through breaking up hourly and shifting it for standing and walking behaviours would substantially increase total (TEE) and PA energy expenditure (PAEE) compared to a week of habitual prolonged SB, in male and female overweight/obese inactive (which do not attained MVPA recommendations) and sedentary desk workers. Specifically using an experiment design our main aims are: a) to determine the impact of reducing SB on TEE and PAEE; b) to analyse the independent effects of interrupting SB through breaks and the overall reduction in SB on TEE and PAEE; c) To analyse the determinants for the overall reduction in SB; d) If the changes occurred in TEE and PAEE were dependent on specific covariates.

Conditions

Risk Reduction Behavior

Keywords

Sedentary Behavior; Breaks; Workplace; Energy Expenditure; Physical activity; doubly labeled water

Outcome Measures

Primary Outcomes (10)

• Change from control week and intervention week in total energy expenditure (TEE)

  The TEE was estimated by the doubly labeled water technique

  week 1 and week 2

• Resting energy expenditure (REE)

  REE was measured by indirect calorimetry

  Baseline (day 0)

• Change from control week and intervention week in physical activity energy expenditure (PAEE)

  PAEE was calculated as the difference between TEE and the sum of the REE and the thermogenic effect of food (assumed to be 10% of TEE)

  week 1 and week 2

• Change from control week and intervention week in daily time spent in sedentary (SB)

  PA variables were assessed using an accelerometer, a combined device that measures accelerometry and heart rate (actiheart)

  week 1 and week 2

• Change from control week and intervention week in light (LIPA), moderate and vigorous (MVPA) intensity activities

  PA variables were assessed using an accelerometer, a combined device that measures accelerometry and heart rate (actiheart)

  week 1 and week 2

• Change from control week and intervention week in number of breaks in sedentary time (BST)

  PA variables were assessed using an accelerometer, a combined device that measures accelerometry and heart rate (actiheart), and an inclinometer (activpal)

  week 1 and week 2

• Change from control week and intervention week in time spent sitting (TSS)

  An inclinometer (activpal)

  week 1 and week 2

• Change from control week and intervention week in time spent standing (TSst)

  An inclinometer (activpal)

  week 1 and week 2

• Change from control week and intervention week in time spent walking (TSW)

  An inclinometer (activpal)

  week 1 and week 2

• Change from control week and intervention week in number of steps

  Steps were assessed using an accelerometer, a combined device that measures accelerometry and heart rate (actiheart), an inclinometer (activpal) and a pedometer.

  week 1 and week 2

Secondary Outcomes (1)

• Change from baseline and intervention week in body composition

  Baseline (day 0) and final day of intervention week

Study Arms (2)

Lifestyle change

EXPERIMENTAL

One 5-10 minute break per hour during the work day using a software that alert the participant, and perform 6000 steps above the baseline number of steps/day (previously evaluated), by adopting several domain specific strategies, during 7 days.

Behavioral: Reduction of sedentary time by breaking it with low intensity physical activity

Control

NO INTERVENTION

Regular free week with no changes performed

Interventions

Reduction of sedentary time by breaking it with low intensity physical activity BEHAVIORAL

One 5-10 minute break per hour during the work day using a software that alert the participant, and perform 6000 steps above the baseline number of steps/day (previously evaluated), by adopting several domain specific strategies, during 7 days.

Also known as: LIPA, breaks

Lifestyle change

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants were required to be sedentary, between 18-65 years old, have a BMI above 25.0 kg/m2 and physical inactive (not meeting the MVPA recommendations and not exceed 6000 steps/day). In addition subjects had to be free of any major disease with a general healthy status warranted.

You may not qualify if:

• Taking any medication or dietary supplements that may interfere with body composition or energy expenditure regulation, performing more than 5000 steps/day and meeting actual MVPA recommendations

Sponsors & Collaborators

• Technical University of Lisbon: lead

Study Sites (1)

Exercise and Health Laboratory, Faculty of Human Kinetics, University of Lisboa

Cruz Quebrada, Lisbon District, 1495, Portugal

Location

Related Publications (3)

• Judice PB, Teixeira L, Silva AM, Sardinha LB. Accuracy of Actigraph inclinometer to classify free-living postures and motion in adults with overweight and obesity. J Sports Sci. 2019 Aug;37(15):1708-1716. doi: 10.1080/02640414.2019.1586281. Epub 2019 Mar 7.

  PMID: 30843462 DERIVED

• Judice PB, Hamilton MT, Sardinha LB, Silva AM. Randomized controlled pilot of an intervention to reduce and break-up overweight/obese adults' overall sitting-time. Trials. 2015 Nov 2;16:490. doi: 10.1186/s13063-015-1015-4.

  PMID: 26525049 DERIVED

• Judice PB, Santos DA, Hamilton MT, Sardinha LB, Silva AM. Validity of GT3X and Actiheart to estimate sedentary time and breaks using ActivPAL as the reference in free-living conditions. Gait Posture. 2015 May;41(4):917-22. doi: 10.1016/j.gaitpost.2015.03.326. Epub 2015 Mar 30.

  PMID: 25852024 DERIVED

MeSH Terms

Conditions

Risk Reduction Behavior; Sedentary Behavior; Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Analiza M Silva, PhD

  Faculty of Human Kinetics, University of Lisboa

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Analiza M Silva

Study Record Dates

• First Submitted: November 26, 2013
• First Posted: December 11, 2013
• Study Start: September 1, 2013
• Primary Completion: September 1, 2013
• Study Completion: November 1, 2013
• Last Updated: December 11, 2013

Record last verified: 2013-12

Locations

PT (1)