Marathon Runners Compared to Sedentary Matched Control Subjects
Fitness, Glucosemetabolism, Cognitive Function, Bodycomposition and Muscular Function in Active Runners and Matched Controls
1 other identifier
observational
200
1 country
1
Brief Summary
The investigators wish to compare very active runners in healthy untrained control subjects on a number of parameters. The project aims to understand the underlying mechanisms by which physical inactivity causes diseases. This the investigators will study the full spectrum of physical activity, from the most inert of the most active people. The investigators have already collected muscle biopsies and established stem cells from people with Type 2 diabetes, obese healthy and normal weight healthy. In this study, the investigators will establish a cohort of highly physically active marathon runners. In a case-control design, the investigators compare muscle stem cell function across the entire spectrum of physical activity / inactivity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2010
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2010
CompletedFirst Submitted
Initial submission to the registry
May 18, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2013
CompletedFirst Posted
Study publicly available on registry
December 5, 2013
CompletedDecember 5, 2013
November 1, 2013
3 years
May 18, 2011
November 28, 2013
Conditions
Outcome Measures
Primary Outcomes (5)
Fitness
Lactate threshold VO2max Running economy Lactate Peak
one day
Cognitive Function
Memory, concentration, personality, intelligence
one day
Blood
3 hour Oral Glucose Tolerance test (glucose, insulin, c-peptide) Fasting blood measurements ( lever, kidney, immune system, colesterol parameters) DNA
one day
Muscle biopsy
Gene transcription Methylation
one day
Body Composition
DXA scanning: Fat%, muscle mass, lean body mass, BMD MR scanning: Amount of visceral fat, volume of thighs
one day
Secondary Outcomes (1)
Activity level and diet
7 days
Study Arms (2)
Marathon runners
Very active runners that have been running \> 10 marathons, 2 within the last year, or an amount of 50 km/week for the last 5 years
Control subjects
Healthy normal weight control subjects, with a low activity level \< 1 hour phsyical activity pr. week. They are matched with runners on age, BMI and gender
Eligibility Criteria
Runners with high amount of training
You may qualify if:
- marathons, 2 within the last year or 50 km/week the last 5 years
You may not qualify if:
- smokers, any medication, chronic diseases, digestion of performance enhancing drugs, pregnancy, alcohol abuse
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Inge Holmlead
- The Augustinus Foundation, Denmark.collaborator
Study Sites (1)
Center of Inflammation and Metabolism, Rigshospitalet
Copenhagen, 2100, Denmark
Biospecimen
Whole blood, plasma, muscle tissue
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Bente K Pedersen, Doctor
Center of Inflammation and Metabolism
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Head of Section CIM
Study Record Dates
First Submitted
May 18, 2011
First Posted
December 5, 2013
Study Start
December 1, 2010
Primary Completion
December 1, 2013
Study Completion
December 1, 2013
Last Updated
December 5, 2013
Record last verified: 2013-11