Gene Polymorphism Study of Normal Individual Inflammasome Genes
Immunological Characterization of Blood and Inflammasome Gene Segment Polymorphism Analysis of Normal Healthy Individuals
1 other identifier
observational
N/A
1 country
1
Brief Summary
This study is intended to collect blood from healthy individuals to investigate whether variations in immune-related (inflammasome) genes affect how the immune cells found in the blood can help fight infections and prevent diseases.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Feb 2013
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2013
CompletedFirst Submitted
Initial submission to the registry
November 14, 2013
CompletedFirst Posted
Study publicly available on registry
November 20, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2014
CompletedOctober 17, 2014
October 1, 2014
1 year
November 14, 2013
October 16, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
analyze their ability to respond to exogenous challenges by changing the production of proteins, the expression of genes and their ability to migrate and ingest materials
Our intent is to collect these cells, divide them into subtypes such as monocytes, lymphocytes and neutrophils and then to analyze their ability to respond to exogenous challenges by changing the production of proteins, the expression of genes and their ability to migrate and ingest materials. We additionally will be interested in examining the cell components that may be released from these cells during various in vitro challenges.
one visit
Study Arms (1)
Blood Draw
Normal healthy individuals will be consented and their blood drawn at the time of their visit.
Interventions
Eligibility Criteria
Normal volunteers.
You may qualify if:
- Healthy with no chronic or acute illnesses, or taking medication which in the opinion of the PI would impact the analyses being conducted.
- At least 18 years or older.
- Are capable of reading, understanding and providing written informed consent.
You may not qualify if:
- Non-English speaking.
- Individuals under 18 years old.
- Woman who believe they are or may be pregnant. (Based on self reporting. Pregnancy testing will not be conducted for the purposes of this study)
- Individuals experiencing acute or chronic illnesses which in the opinion of the PI would impact the analyses being conducted.
- Currently taking prescription or over the counter medication which in the opinion of the PI would impact the analyses being conducted.
- Individual has donated blood more than twice in the last week or the amount to be drawn will exceed the maximum allowance in the last 8 weeks.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Davis Heart & Lung Research Institute
Columbus, Ohio, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Director, Pulmonary Research
Study Record Dates
First Submitted
November 14, 2013
First Posted
November 20, 2013
Study Start
February 1, 2013
Primary Completion
February 1, 2014
Study Completion
February 1, 2014
Last Updated
October 17, 2014
Record last verified: 2014-10