Health Effects of Resistance Training on Postmenopausal Women

NCT01987778 | Completed

• 1 other identifier: 20131105/Styrka
• Study Type: interventional
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

Today's women will live more than a third of their lives after menopause, i.e. with a changed hormonal and metabolic state. Vasomotor symptoms like hot flushes and sweating are reported by about 75% of all women around menopause and may impair well-being, mental state, daily activities and night sleep. Vasomotor symptoms are less prevalent in women who participate in regular physical exercise. It is, however, still uncertain if physical exercise reduces vasomotor symptoms. The purpose of this randomized controlled study is to establish possible beneficial health effects from 15 weeks of supervised resistance training (RT) on postmenopausal women. End-points include effects from RT in postmenopausal women on

1. 1.clinical outcomes (number and severity of vasomotor symptoms, Health-Related quality of Life (HRQoL), Body Mass Index (BMI), abdominal height, muscle strength and mass, browning of fat),
2. 2.diagnostic variables (production of myokines as irisin, immunological markers) and
3. 3.genetic variables (length of telomeres).

Conditions

Hot Flashes; Menopause

Keywords

Hot flashes; Menopause; HRQoL; Resistance training; Physical activity; Adipose tissue

Outcome Measures

Primary Outcomes (1)

• Change in frequency of hot flushes per 24 h

  Frequency of hot flushes per 24 h daily recorded in hot flush diary from baseline throughout 15 weeks of intervention. Comparison between intervention group and control group.

  Baseline to 15 weeks of intervention/control group

Secondary Outcomes (9)

• Health-related quality of life (HRQoL)

  Baseline to 15 weeks of intervention/control group. Follow-up after 6 and 24 months.

• Muscle strength

  Baseline to 15 weeks of intervention

• Level of physical activity

  Baseline to 15 weeks of intervention/control group. Follow-up after 6 and 24 months.

• Concentrations of adipo-myokines/inflammatory biomarkers

  Baseline to 15 weeks of intervention/control group

• Length of telomeres

  Baseline to 15 weeks of intervention/control group

Study Arms (2)

Resistance training

EXPERIMENTAL

The resistance training will be supervised and individualized by an experienced physiotherapist. First the relative load will be lighter during three weeks, thereafter the intensity and load will be increased over another 12 weeks.

Other: Resistance training

Control group

NO INTERVENTION

No intervention for 15 weeks but the same registrations, diaries and forms as the intervention group. The control group will however be omitted from muscle strength testing.

Interventions

Resistance training OTHER

Resistance training supervised and individualized by an experienced physiotherapist. First the relative load will be lighter during three weeks, thereafter the intensity and load will be increased over another 12 weeks.

Resistance training

Eligibility Criteria

• Age: 45 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Postmenopausal women who had at least 28 moderate to severe hot flashes per week during a screening period of two weeks.(Postmenopausal, i.e. had their last menstrual bleeding at least 12 months ago or have increased gonadotrophic hormones showing they are postmenopausal.)
• At lest 45 years of age
• Good physical health and physical ability to take part in organized resistance training or other training at least three times per week.
• Ability to speak and read Swedish
• Freely informed consent for participation

You may not qualify if:

• Physically active more than 75 minutes of intense exercise per week or more than 150 minutes of low intensity activities
• Hb \<110 g/l
• Blood pressure \>160 systolic and/or \>100 mmHg diastolic pressure
• Ongoing usage or use during the last two months of hormone therapy aimed for hot flashes
• Treatment with psychopharmacological drugs (e.g SSRI or SNRI) or other treatment with a possible effect on menopausal symptoms
• Uninvestigated or unstable disease that could affect presence of flushes (e.g thyroid disease)
• Other medical condition that is judged inappropriate to combine with physical activity or participation in the study.

Sponsors & Collaborators

• Ostergotland County Council, Sweden: lead
• Linkoeping University: collaborator

Study Sites (1)

County Council of Östergötland, Kvinnokliniken

Linköping, 58185, Sweden

Location

Related Publications (14)

• Dahlqvist Leinhard O, Johansson A, Rydell J, Smedby Ö, Nyström F, Lundberg P, Borga M. Quantitative Abdominal Fat Estimation Using MRI. 2008 19th International Conference on Pattern Recognition, ICPR 2008 , art. no. 4761764.

  BACKGROUND

• Lidell ME, Betz MJ, Dahlqvist Leinhard O, Heglind M, Elander L, Slawik M, Mussack T, Nilsson D, Romu T, Nuutila P, Virtanen KA, Beuschlein F, Persson A, Borga M, Enerback S. Evidence for two types of brown adipose tissue in humans. Nat Med. 2013 May;19(5):631-4. doi: 10.1038/nm.3017. Epub 2013 Apr 21.

  PMID: 23603813 BACKGROUND

• Borga M, Virtanen KA, Romu T, Leinhard OD, Persson A, Nuutila P, Enerback S. Brown adipose tissue in humans: detection and functional analysis using PET (positron emission tomography), MRI (magnetic resonance imaging), and DECT (dual energy computed tomography). Methods Enzymol. 2014;537:141-59. doi: 10.1016/B978-0-12-411619-1.00008-2.

  PMID: 24480345 BACKGROUND

• Karlsson A, Rosander J, Tallberg J, Romu T, Borga M, Dahlqvist Leinhard O. Whole Body Muscle Classification using Multiple Prototype Voting. Proceedings of the ISMRM Annual Meeting (ISMRM'13), 2013.

  BACKGROUND

• Daley A, Stokes-Lampard H, Macarthur C. Exercise for vasomotor menopausal symptoms. Cochrane Database Syst Rev. 2011 May 11;(5):CD006108. doi: 10.1002/14651858.CD006108.pub3.

  PMID: 21563149 BACKGROUND

• Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010 Jun 3;411(11-12):785-93. doi: 10.1016/j.cca.2010.02.069. Epub 2010 Feb 25.

  PMID: 20188719 BACKGROUND

• Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB.

  PMID: 12900694 BACKGROUND

• Ivarsson T, Spetz AC, Hammar M. Physical exercise and vasomotor symptoms in postmenopausal women. Maturitas. 1998 Jun 3;29(2):139-46. doi: 10.1016/s0378-5122(98)00004-8.

  PMID: 9651903 BACKGROUND

• Kim JH, Ko JH, Lee DC, Lim I, Bang H. Habitual physical exercise has beneficial effects on telomere length in postmenopausal women. Menopause. 2012 Oct;19(10):1109-15. doi: 10.1097/gme.0b013e3182503e97.

  PMID: 22668817 BACKGROUND

• Lindh-Astrand L, Nedstrand E, Wyon Y, Hammar M. Vasomotor symptoms and quality of life in previously sedentary postmenopausal women randomised to physical activity or estrogen therapy. Maturitas. 2004 Jun 15;48(2):97-105. doi: 10.1016/S0378-5122(03)00187-7.

  PMID: 15172083 BACKGROUND

• Taylor JD, Fletcher JP. Reliability of the 8-repetition maximum test in men and women. J Sci Med Sport. 2012 Jan;15(1):69-73. doi: 10.1016/j.jsams.2011.07.002. Epub 2011 Aug 5.

  PMID: 21820961 BACKGROUND

• Nilsson S, Henriksson M, Hammar M, Berin E, Lawesson SS, Ward LJ, Li W, Holm AS. A 2-year follow-up to a randomized controlled trial on resistance training in postmenopausal women: vasomotor symptoms, quality of life and cardiovascular risk markers. BMC Womens Health. 2024 Sep 13;24(1):511. doi: 10.1186/s12905-024-03351-1.

  PMID: 39272114 DERIVED

• Nilsson S, Hammar M, West J, Borga M, Thorell S, Spetz Holm AC. Resistance training decreased abdominal adiposity in postmenopausal women. Maturitas. 2023 Oct;176:107794. doi: 10.1016/j.maturitas.2023.107794. Epub 2023 Jul 6.

  PMID: 37421844 DERIVED

• Berin E, Spetz Holm AC, Hammar M, Lindh-Astrand L, Bertero C. Postmenopausal women's experiences of a resistance training intervention against vasomotor symptoms: a qualitative study. BMC Womens Health. 2022 Jul 30;22(1):320. doi: 10.1186/s12905-022-01900-0.

  PMID: 35907840 DERIVED

MeSH Terms

Conditions

Hot Flashes; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Mats L Hammar, Professor

  Linkoeping University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, professor

Study Record Dates

• First Submitted: November 13, 2013
• First Posted: November 19, 2013
• Study Start: November 1, 2013
• Primary Completion: March 2, 2017
• Study Completion: June 1, 2020
• Last Updated: February 24, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)