Brain Mechanisms of Human Motivation

NCT01976975 | Completed Results

• 1 other identifier: 2013-P-001352
• Study Type: observational
• Target: 270
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate reward learning across the mood disorder spectrum and to investigate the predictive validity of reward learning for subsequent symptom severity.

Conditions

Major Depressive Disorder; Bipolar Disorder

Keywords

Depression; Major Depressive Disorder; Bipolar Disorder; Mania; Hypomania; EEG; MRI; Reward

Outcome Measures

Primary Outcomes (2)

• Change in Response Bias

  The Probabilistic Reward Task (PRT) is a behavioral task that measures an individual's ability to learn to choose a more rewarding outcome versus a less rewarding one (Response Bias). The response bias score is a ratio of the number of times a participant correctly chooses the high reward stimulus (the "rich" stimulus) versus the low reward stimulus (the "lean" stimulus). Response bias scores range between -1 and +1. A higher Response Bias score indicates a stronger bias toward the rich stimulus, and a negative Response Bias indicates a stronger bias toward the lean stimulus. The Change-in-Response-Bias is calculated by subtracting Response Bias in block 1 (trials 0-100) of the task from Response Bias in block 3 (trials 201-300) of the task. This metric represents the degree to which an individual is able to update behavior as a function of the asymmetrical reinforcement schedule.

  Administered during the first session.

• Mean Accuracy on Gain Trials During an Instrumental Learning Task

  The instrumental learning task requires participants to choose between two abstract symbols. Each symbol in the pair is associated with an 80% or 20% probability of a given outcome (gain: win $1 or $0; loss: lose $1 or $0; neutral: view a gray square or see the word 'nothing'). The task consists of three blocks. Behavioral performance focuses on the number of times the participant chose the symbol that was associated more frequently associated with the more desirable outcome. A participant scores 1 if they choose correctly, and 0 if they choose in correctly, and correct choices across all three blocks are added and converted to a percentage relative to the total number of trials in that condition (i.e., gain, loss, or neutral). This study focused on percent of accuracy responses in the gain condition.

  Administered in session 3 during 1.5 hour MR scan

Secondary Outcomes (1)

• Symptom Severity at 6 Month Follow-up

  6 months

Study Arms (2)

Mood disorder patients

Patients with depressive and/or manic or hypomanic symptoms

Healthy controls

Participants with no lifetime history of psychiatric illness

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

We are studying a population with depressive and/or manic or hypomanic symptoms, as well as healthy controls.

You may qualify if:

• Written informed consent
• Right-handed
• (For mood disorder group only) Stable medication over the past 8 weeks OR absence of any psychotropic medications for at least 2 weeks (for follow-up analyses testing effects in medication-free patients):
• weeks for fluoxetine,
• months for neuroleptics,
• weeks for benzodiazepines,
• weeks for any other antidepressants
• weeks for any mood-stabilizers

You may not qualify if:

• Suicidal ideation where outpatient treatment is determined unsafe by the study clinician
• Pregnant women or women of childbearing potential who 1) have not completed a negative urine pregnancy test prior to the MRI scan and/or 2) are seeking to become pregnant or believe that they may be pregnant
• Serious/unstable medical illness (e.g., cardiovascular, renal, endocrine, neurologic disease)
• Clinical or laboratory evidence of hypothyroidism
• History of seizure disorder, history or current diagnosis of dementia, score \< 26 on the MMSE at screening
• History or current diagnosis of the following DSM-IV psychiatric illness: organic mental disorder, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorder NOS, patients with mood congruent or mood incongruent psychotic features, anorexia nervosa, obsessive compulsive disorder
• Lifetime history of stimulant dependence (e.g., cocaine, amphetamines)
• Current use of Methylphenidate (Ritalin) and other ADHD medications with dopaminergic effects
• Patients with a lifetime history of electroconvulsive therapy (ECT)
• Failure to meet standard MRI safety requirements

Sponsors & Collaborators

• Mclean Hospital: lead

Study Sites (1)

McLean Hospital

Belmont, Massachusetts, 02478, United States

Location

Related Publications (2)

• Pizzagalli D, Whitton A, Treadway M, Rutherford A, Kumar P, Ironside M, Kaiser R, Ren B, Dan R. Brain-based graph-theoretical predictive modeling to map the trajectory of transdiagnostic symptoms of anhedonia, impulsivity, and hypomania from the human functional connectome. Res Sq [Preprint]. 2023 Sep 28:rs.3.rs-3168186. doi: 10.21203/rs.3.rs-3168186/v1.

  PMID: 37841877 DERIVED

• Whitton AE, Kumar P, Treadway MT, Rutherford AV, Ironside ML, Foti D, Fitzmaurice G, Du F, Pizzagalli DA. Distinct profiles of anhedonia and reward processing and their prospective associations with quality of life among individuals with mood disorders. Mol Psychiatry. 2023 Dec;28(12):5272-5281. doi: 10.1038/s41380-023-02165-1. Epub 2023 Jul 4.

  PMID: 37402852 DERIVED

MeSH Terms

Conditions

Depressive Disorder, Major; Bipolar Disorder; Depression; Mania

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders; Bipolar and Related Disorders; Behavioral Symptoms; Behavior; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: David Crowley
• Organization: McLean Hospital

djcrowley@mclean.harvard.edu

6178554432

Study Officials

• Diego A Pizzagalli, Ph.D.

  Mclean Hospital

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Department of Psychiatry, Harvard Medical School

Study Record Dates

• First Submitted: October 25, 2013
• First Posted: November 6, 2013
• Study Start: October 1, 2013
• Primary Completion: January 1, 2018
• Study Completion: January 1, 2018
• Last Updated: August 4, 2021
• Results First Posted: April 23, 2019

Record last verified: 2021-08

Locations

US (1)