Mapping and Stimulating the Limbic Areas of the Subthalamic Nucleus

You may not qualify if:

• A diagnosis of severe major depression disorder (MDD) with psychotic features
• Significant suicidal risk \[Hamilton Depression scale item 3 (suicide) \>2\]
• Lifetime history of substance or alcohol dependence or of abuse in the preceding 12 months
• Significant cognitive decline, as measured by Addenbrooke's Cognitive Examination (ACE) \< 75 and the Frontal Assessment Battery (FAB) \< 10.
• Significant cognitive impairment that would affect a participant's ability to give informed consent or provide interview or self-report data reliably
• Any clinically significant abnormality on preoperative MRI
• Any DBS contraindication, infection, coagulopathy, significant cardiac risk factors, or other medical risk factors for surgery
• Pregnant and/or woman of childbearing age not using effective forms of birth control
• Obsessive-compulsive disorder (OCD), diagnosed by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (SCID-IV)
• Presence of disabling severity, as assessed by a Yale-Brown Obsessive Compulsive Scale (YBOCS) score of at least 25
• Documented highly treatment refractory OCD; the documentation must demonstrate persistence of severe symptoms and impairment for 5 or more years despite both pharmacological and psychological treatments.
• Either drug free or on a stable drug regimen for at least 6 weeks before study entry
• General good overall health
• Age 20-70 years
• Male or female
• +11 more criteria