A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment
1 other identifier
interventional
72
1 country
1
Brief Summary
The purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older Veterans with amnestic Mild Cognitive Impairment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2013
CompletedFirst Submitted
Initial submission to the registry
August 26, 2013
CompletedFirst Posted
Study publicly available on registry
October 14, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2017
CompletedApril 5, 2018
April 1, 2018
4.2 years
August 26, 2013
April 3, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change from Baseline to 28 weeks in delayed recall of a word list
Baseline, 24 weeks, 28 weeks
Change from Baseline to 28 weeks in Delayed Recall of Names-Face Task
Baseline, 24 weeks, 28 weeks
Secondary Outcomes (1)
Non-Cognitive Outcomes (Depression, Sleep, Quality of Life)
Baseline, Time 2, Time 3
Other Outcomes (1)
Exercise Assessment
Baseline, Time 2, and Time 3
Study Arms (2)
Combined Aerobic and Resistance Exercise/Cognitive Training
ACTIVE COMPARATORStretching Exercises/Cognitive Training
ACTIVE COMPARATORInterventions
Gym and home based aerobic and resistance exercises
Gym and home based stretching exercises
Group-based cognitive training
Eligibility Criteria
You may qualify if:
- diagnosis of amnestic Mild Cognitive Impairment
- available informant
- visual and auditory acuity to allow neuropsychological testing
- willingness to participate in exercise training + cognitive training for 8 months
- approval of primary provider to participate in exercise trial
You may not qualify if:
- current severe psychiatric disorder
- diagnosis of dementia
- history of neurological or system illness affecting CNS function
- acute illness or unstable chronic illness
- current severe cardiac disease
- inability to exercise consistently because of orthopedic or musculoskeletal problems
- morbid obesity
- inability to read, verbalize understanding and voluntarily sign the informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
VA Palo Alto Health Care System
Palo Alto, California, 94304, United States
Related Publications (1)
Fairchild JK, Myers J, Louras P, Jo B, McNerney MW, Hallmayer J, Yesavage J. Multimodal Exercise and Cognitive Training Program Improves Cognitive Function in Amnestic Mild Cognitive Impairment. Am J Geriatr Psychiatry. 2024 Apr;32(4):463-474. doi: 10.1016/j.jagp.2023.12.002. Epub 2023 Dec 11.
PMID: 38220592DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jennifer K Fairchild, PhD
VA Palo Alto Health Care System
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Clinical Psychologist
Study Record Dates
First Submitted
August 26, 2013
First Posted
October 14, 2013
Study Start
May 1, 2013
Primary Completion
July 1, 2017
Study Completion
November 1, 2017
Last Updated
April 5, 2018
Record last verified: 2018-04