Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment

NCT00643266 | Completed

• 3 other identifiers: RecollectionTrainingCIHR MOP 67015ASC 08 95
• Study Type: interventional
• Target: 91
• Locations: 1 country
• Sites: 1

Brief Summary

We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful, Recollection-based memory processes, whereas their automatic, Familiarity-based memory processes are intact. Our primary current goal is to investigate whether our successful memory intervention will improve Recollection and produce induce altered patterns of brain activity in the Lo-Old and aMCI. Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI.

Conditions

Amnestic Mild Cognitive Impairment; Aging

Keywords

recollection training; aging; amnestic mild cognitive impairment; fMRI

Outcome Measures

Primary Outcomes (1)

• Recollection estimates

  Recollection, defined as Correct "yes" responses to "Same" repetitions minus Incorrect "yes" responses to "Different" repetitions, as a function of condition (trained versus control), lag (3, 16) and time (pre-, post-, and 3 month follow-up)

  Immediately post-training and three months post-training

Secondary Outcomes (2)

• Brain activation as assessed by functional magnetic resonance imaging

  Immediately post-training

• Transfer to other recollection-dependent task and to subjective memory measures

  Immediately post-training and three months post-training

Study Arms (2)

1

EXPERIMENTAL

Recollection training via graduated increases in task difficulty, carried out over 36 sessions over 9 training days

Behavioral: Recollection Training

2

ACTIVE COMPARATOR

Computer-delivered information sessions about memory and aging with Jeopardy-like games to engage participants

Behavioral: Control

Interventions

Recollection Training BEHAVIORAL

Participants are exposed to long lists of words. Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality. Participants are instructed to respond "yes" only to words repeated in the same modality. If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.

Also known as: Memory training

1

Control BEHAVIORAL

Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain

Also known as: Educational Control

2

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• years old
• English as a first language or learned before kindergarten
• Right handed

You may not qualify if:

• Neurologic disorder
• Major medical disorder affecting cognition
• Psychiatric disorder
• Metal in the body that poses a hazard in the MRI scanner

Sponsors & Collaborators

• Baycrest: lead

Study Sites (1)

Baycrest

Toronto, Ontario, M6A 2E1, Canada

Location

Related Publications (5)

• Anderson ND, Ebert PL, Jennings JM, Grady CL, Cabeza R, Graham SJ. Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology. 2008 Mar;22(2):177-87. doi: 10.1037/0894-4105.22.2.177.

  PMID: 18331160 RESULT

• Guild EB, Vasquez BP, Maione AM, Mah L, Ween J, Anderson ND. Dynamic working memory performance in individuals with single-domain amnestic mild cognitive impairment. J Clin Exp Neuropsychol. 2014;36(7):751-60. doi: 10.1080/13803395.2014.941790. Epub 2014 Aug 30.

  PMID: 25175752 RESULT

• Ebert PL, Anderson ND. Proactive and retroactive interference in young adults, healthy older adults, and older adults with amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2009 Jan;15(1):83-93. doi: 10.1017/S1355617708090115.

  PMID: 19128531 RESULT

• Anderson ND, Ebert PL, Grady CL, Jennings JM. Repetition lag training eliminates age-related recollection deficits (and gains are maintained after three months) but does not transfer: Implications for the fractionation of recollection. Psychol Aging. 2018 Feb;33(1):93-108. doi: 10.1037/pag0000214.

  PMID: 29494181 RESULT

• Meusel LA, Grady CL, Ebert PE, Anderson ND. Brain-behavior relationships in source memory: Effects of age and memory ability. Cortex. 2017 Jun;91:221-233. doi: 10.1016/j.cortex.2016.12.023. Epub 2017 Jan 12.

  PMID: 28161030 RESULT

MeSH Terms

Interventions

Cognitive Training

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Nicole D Anderson, PhD, CPsych

  Baycrest

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Scientist

Study Record Dates

• First Submitted: February 26, 2008
• First Posted: March 26, 2008
• Study Start: February 1, 2008
• Primary Completion: August 1, 2013
• Study Completion: August 1, 2013
• Last Updated: November 16, 2018

Record last verified: 2018-11

Locations

CA (1)