Biomarkers In Retinitis Pigmentosa (BIRP)

NCT01949623 | Completed

• 1 other identifier: BIRP
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, markers of oxidative stress will be measured in the aqueous humour and plasma of RP patients compared to controls.

Conditions

Retinitis Pigmentosa

Keywords

RP

Outcome Measures

Primary Outcomes (1)

• Aqueous levels of markers of oxidative stress in patients with RP and controls.

  2 years

Study Arms (2)

RP patients

Retinitis Pigmentosa patients

Other: Anterior Chamber (AC) tap

Controls

Patients who will be undergoing surgery for macular hole, epiretinal membrane, or vitreomacular traction, patients who have a retinal detachment , patients with neovascular age related macular degeneration and patients with diabetic retinopathy.

Other: Anterior Chamber (AC) tap

Interventions

Anterior Chamber (AC) tap OTHER

Aqueous Samples will be collected for measurement of biomarkers

Controls; RP patients

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Retinitis Pigmentosa patients and Controls

You may qualify if:

• Signed informed consent and authorization of use and disclosure of protected health information
• Age more than or equal to 18 years
• For the study group, patients diagnosed with Retinitis Pigmentosa by the investigators
• For the control group, patients undergoing vitreoretinal surgery for macular hole, epiretinal membrane, vitreomacular traction, retinal detachment, neovascular Age-related Macular Degeneration (AMD) and Diabetic Retinopathy will be eligible

You may not qualify if:

• Patients with active or suspected ocular or periocular infection

Sponsors & Collaborators

• Johns Hopkins University: lead

Study Sites (1)

Wilmer Eye Institute

Baltimore, Maryland, 21287, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Anterior Chamber fluid from the eye

MeSH Terms

Conditions

Retinitis Pigmentosa

Interventions

Paracentesis

Condition Hierarchy (Ancestors)

Eye Diseases, Hereditary; Eye Diseases; Retinal Dystrophies; Retinal Degeneration; Retinal Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Drainage; Therapeutics; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Peter Campochiaro, MD

  Johns Hopkins University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 20, 2013
• First Posted: September 24, 2013
• Study Start: September 1, 2013
• Primary Completion: June 1, 2017
• Study Completion: July 1, 2017
• Last Updated: August 16, 2017

Record last verified: 2017-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)