NCT01947517

Brief Summary

The purpose of this study is to determine if Parasol punctal occluders (Brand A) have a higher rate of retention than Superflex punctal plugs (Brand B).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
52

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Sep 2013

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2013

Completed
16 days until next milestone

First Submitted

Initial submission to the registry

September 17, 2013

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 20, 2013

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2014

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2014

Completed
2.9 years until next milestone

Results Posted

Study results publicly available

June 16, 2017

Completed
Last Updated

June 16, 2017

Status Verified

March 1, 2017

Enrollment Period

8 months

First QC Date

September 17, 2013

Results QC Date

October 1, 2015

Last Update Submit

March 30, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • Length of Retention

    6 months

Secondary Outcomes (4)

  • Canadian Dry Eye Assessment Score

    6 months

  • National Eye Institute Corneal Fluorescein Staining Pattern

    6 months

  • National Eye Institute Grading for Conjunctival Staining

    6 months

  • Tear Meniscus Height

    6 months

Study Arms (2)

Parasol Punctal Occluder Group

Randomized to receive Brand A punctal plugs

Device: Parasol Punctal Occluder

Superflex Punctal Occluder Group

Randomized to receive Group B punctal plugs

Device: Superflex Punctal Occluder

Interventions

Patients will be randomized to receive one of these 2 punctal occluders in the management of dry eyes.

Parasol Punctal Occluder Group

Patients will be randomized to receive one of these 2 punctal occluders in the management of dry eyes.

Superflex Punctal Occluder Group

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients will be recruited from cornea and general ophthalmology specialist practices at Hotel Dieu Hospital, Queens University

You may qualify if:

  • moderate dry eye, severe dry eye

You may not qualify if:

  • silicone allergy, punctal stenosis, punctal occlusion, punctal cautery

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Ophthalmology, Hotel Dieu Hospital

Kingston, Ontario, K7L 5G2, Canada

Location

MeSH Terms

Conditions

Dry Eye Syndromes

Condition Hierarchy (Ancestors)

Lacrimal Apparatus DiseasesEye Diseases

Results Point of Contact

Title
Dr. Stephanie Baxter
Organization
Queen's University

Study Officials

  • Ashley R Brissette, BSc, MD

    Queens University

    STUDY DIRECTOR
  • Stephanie Baxter, MD, FRCSC

    Queens University

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Program Director Department of Ophthalmology

Study Record Dates

First Submitted

September 17, 2013

First Posted

September 20, 2013

Study Start

September 1, 2013

Primary Completion

May 1, 2014

Study Completion

August 1, 2014

Last Updated

June 16, 2017

Results First Posted

June 16, 2017

Record last verified: 2017-03

Data Sharing

IPD Sharing
Will not share

Locations