Multidisciplinary Program "Optimization of Drug Prescription" : Impact on the Quality of Drug Prescription in Hospitalized Elderly Patients

NCT01947270 | Completed

• 1 other identifier: D50789
• Study Type: observational
• Target: 3,055
• Locations: 1 country
• Sites: 1

Brief Summary

Drug prescription is a fundamental component of care for the elderly. Even if drugs are a chance for the older patient, because of changes in pharmacological, pharmacokinetic and pharmacodynamic parameters related with age and acute/or chronic pathologies, the risks associated with drug prescription, particularly those associated with potentially inappropriate medication (PIM), are increased in the elderly. We suppose that many of hospitalized elderly have at least one prescribed medication without valid indication. Conversely, many diseases are currently undertreated in elderly patients: e.g. medicines used to treat heart failure and osteoporosis are underused in 20 to 70% of patients. Moreover, PMI prescription is associated with an increased of morbidity, mortality, risk of drug-related adverse events, utilization of health care system, care costs and impairment of quality of life. Thus, optimization of drug prescription is a major concern for improvement of the quality and safety of care in elderly. The investigators' hypothesis is that a multidisciplinary program entitled "Optimisation de la Prescription MEDicamenteuse" ("Optimization of drug prescribing") focused on drug prescription optimization including a physician training to the specificity of the drug prescription in the elderly and a checklist allowing an adapted and standardized pharmaceutical analysis is effective in reducing PIM in elderly patients hospitalized in short-term medical and geriatric care departments.

Conditions

Potentially Inappropriate Medications

Keywords

Potentially inappropriate medications; Elderly; Prevention; Multidisciplinary program; Checklist; Stepped wedge design; AGED, 75 AND OVER

Outcome Measures

Primary Outcomes (1)

• Proportion of potentially inappropriate medications (PIM) prescribed in discharge of hospitalized patients from 75 years old.

  Proportion of prescribed PIM will be expressed as the ratio of PIM to the total number of medication in discharge prescription sheet. PIM will be identified by 2 experts (1 doctor and 1 pharmacist) based on criteria from the lists STOPP/START and Laroche.

  at discharge (average 3 weeks)

Secondary Outcomes (4)

• Total number of drugs prescribed per discharge prescription sheet

  at discharge (average 3 weeks)

• Number of rehospitalization within 12 months following discharge

  12 months after inclusion

• Number of emergency admission within 12 months following hospitalization

  12 months after inclusion

• Mortality within 12 months after hospitalization

  12 months after inclusion

Study Arms (2)

Control group

Patients of this group are hospitalized in a time frame where the multidisciplinary intervention program is not implemented in the medical department. Drug prescriptions are conducted under usual care in the department.

Intervention group

Patients of this group are hospitalized in a time frame where the multidisciplinary intervention program is implemented in the medical department.

Other: " Optimisation de la Prescription MEDicamenteuse " ("Optimization of drug prescribing")

Interventions

" Optimisation de la Prescription MEDicamenteuse " ("Optimization of drug prescribing") OTHER

The multidisciplinary intervention program include: * Awareness and training of doctors by two experts (a geriatrician and a pharmacist) within participating departments. * Implementation of a checklist which aims to conduct an adapted and standardized pharmaceutical analysis

Intervention group

Eligibility Criteria

• Age: 75 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospitalized elderly patients from 75 years old.

You may qualify if:

• Male or female subject aged over 75 years hospitalized in one of the participating department
• Patient agreed to participate

You may not qualify if:

• Patient with a predictive length of stay equal or less than 48 hours
• Patients admitted in terminal illness

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hospices Civils de Lyon - Hôpital Edouard Herriot

Lyon, 69003, France

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 26, 2013
• First Posted: September 20, 2013
• Study Start: January 1, 2013
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: September 28, 2017

Record last verified: 2017-09

Locations

FR (1)