A Pre-Cellular Therapy Observational Study in Early Huntington's Disease

You may not qualify if:

• Very early disease without demonstrable motor signs (diagnostic confidence level \< 4)
• Significant cognitive impairment or dementia as defined by Montreal Cognitive Assessment (MoCA) score \< 12.
• Moderate or advanced disease with TFC \< 9
• Concurrent active unstable psychiatric disease including history of suicide attempts within the last year, major personality or psychiatric disorders.
• History of concurrent serious medical illness such as HIV or current anti-retroviral treatment, cancer, major cardiac, pulmonary, immunological or other organ disease.
• History of coagulopathy, bleeding disorder, or concurrent use of blood thinners.
• History of brain tumor, serious traumatic brain injury with coma, or history of brain surgery.
• Any comorbid condition that presents an unacceptable health risk to the patient in the investigator's view
• Clinically significant laboratory test abnormalities, including full blood count, chemistry panel, liver function tests, Prothrombin time/international normalized ratio (PT/INR), lipid panel, electrocardiogram (EKG), or chest x-ray as judged by the investigator.
• Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with safety or adherence to study requirements.
• History or documentation of contraindication for MRI brain scan, including the presence of pacemaker, neurostimulator, aneurysm clips, artificial heart valves, cochlear implants, metal fragments in the eyes, orbits or skin or any other known contraindication to MRI.
• Any significant MRI brain scan findings other than those characteristic of HD.
• Any contraindications to surgery or to the use of general anesthesia, including allergy.
• History of use of any investigational agent within 60 days prior to enrollment
• History of current or previous gene therapy or stem cell therapy.
• +3 more criteria