Growth Hormone Secretion Following the Anaerobic Exercise
1 other identifier
interventional
100
1 country
1
Brief Summary
Proper growth in children is a complex process regulated by a combination of genetic, nutritional, environmental, hormonal, and others. Growth hormone (GH) is the main hormone regulating the growth from childhood to adulthood. Despite great progress in the field, with the development of recombinant GH for the treatment of growth hormone deficiency (GHD), there is still no reliable method for testing GHD. Physical exertion is one of the significant physiologic stimuli for GH secretion, and it is reliable test for identification of GHD. It is not in use in the clinics because of its complexity. Recently GH secretion following short anaerobic exercise in young adults was tested and also demonstrated significant growth hormone secretion In contrast to adult children's exercise is characterized by an anaerobic nature. There is no data about secretion of growth hormone in response to anaerobic exercise in children. Purpose of the experiment: The purpose of this study is to evaluate the secretion of growth hormone in response to anaerobic exercise in children.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2014
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 19, 2013
CompletedFirst Posted
Study publicly available on registry
September 4, 2013
CompletedStudy Start
First participant enrolled
May 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2020
CompletedOctober 15, 2019
October 1, 2019
5.7 years
August 19, 2013
October 11, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Growth Hormone Release
GH will be measured at the beginning of exercise (time 0), and the change in GH level will be assessed at the end of exercise (30 seconds), after 10 minutes, 30 minutes and 60 minutes
Secondary Outcomes (1)
IGF-1 and Cortisol Release
IGF-1, Cortisol will be taken at the beginning of exercise (time 0), at the end of exercise (30 seconds), after 10 minutes, 30 minutes and 60 minutes
Study Arms (1)
Anaerobic Test
EXPERIMENTALInterventions
To evaluate the secretion of growth hormone in response to anaerobic exercise in children.
Eligibility Criteria
You may qualify if:
- Children evaluated for short stature
- Normal weight \\ overweight \\ obesity
You may not qualify if:
- Known GH deficiency
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Meir Medical Center
Kfar Saba, Israel
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Dan Nemet, MD
Meir Medical Center , Tel Aviv University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. of Pediatric, MD
Study Record Dates
First Submitted
August 19, 2013
First Posted
September 4, 2013
Study Start
May 1, 2014
Primary Completion
December 30, 2019
Study Completion
March 1, 2020
Last Updated
October 15, 2019
Record last verified: 2019-10