Glycemic Index of Mango and Pear in Different Solid Products and Drinks

NCT01929551 | Completed

• 1 other identifier: IGPMJP2013-CINCO
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to compare the glycemic index of a beverage made of natural concentrated mango puree with natural concentrated pear juice with other five different products based on natural mango and pear ingredients in the form of fruit or juice against a control of 50-gram glucose load.

Conditions

Glucose Intolerance

Keywords

glycemic index

Outcome Measures

Primary Outcomes (1)

• Glycemic index of mango puree with natural pear juice beverage

  Glycemic index will be calculated for 450 milliliters of this juice. The results will be expressed as mean ± standard deviation for each with a significance level of 0.05 for all the statistical tests.

  8 days

Secondary Outcomes (6)

• Glycemic index of a commercial mango juice

  8 days

• Glycemic index of natural fresh mango

  8 days

• Glycemic index of natural frozen mango pulp

  8 days

• Glycemic index of processed natural mango pulp

  8 days

• glycemic index of a mixture of fresh mango 73 percent and fresh pear 27 percent

  8 days

Study Arms (7)

Mango puree and pear juice beverage

OTHER

Participants will drink 450 milliliters of the juice at time 0.

Other: Mango puree and pear juice beverage

Commercial mango juice

OTHER

Participants will drink 450 milliliters of the juice at time 0.

Other: Commercial mango juice

Fresh natural mango

OTHER

Participants will eat 400 to 500 grams of frozen mango pulp, along with 250 milliliters of water at time 0.

Other: Fresh natural mango

Frozen natural mango

OTHER

Participants will eat 400 to 500 grams of frozen mango pulp, along with 250 milliliters of water at time 0.

Other: Frozen natural mango

Processed natural mango pulp

OTHER

Participants will eat 400 to 500 grams of frozen mango pulp, along with 250 milliliters of water at time 0.

Other: Processed natural mango pulp

Mix of natural mango and pear

OTHER

Participants will eat 400 to 500 grams of a mixture of fresh natural fruit containing mango (73%) and pear (27%), along with 250 milliliters of water at time 0.

Other: Mix of natural mango and pear

50 grams glucose load

OTHER

Participants will drink 250 milliliters of the standard glucose load at time 0.

Other: 50 grams glucose load

Interventions

Mango puree and pear juice beverage OTHER

Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.

Also known as: Determination of glycemic index of MPPJB.

Mango puree and pear juice beverage

Commercial mango juice OTHER

Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.

Also known as: Determination of glycemic index of commercial mango juice

Commercial mango juice

Fresh natural mango OTHER

Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.

Also known as: Determination of glycemic index of fresh natural mango

Fresh natural mango

Frozen natural mango OTHER

Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.

Also known as: Determination of glycemic index of frozen natural mango

Frozen natural mango

Processed natural mango pulp OTHER

Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.

Also known as: Determination of glycemic index of PNMP.

Processed natural mango pulp

Mix of natural mango and pear OTHER

Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.

Also known as: Determination of glycemic index for mix of NMP.

Mix of natural mango and pear

50 grams glucose load OTHER

Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.

Also known as: Determination of glycemic index for 50 grams glucose load

50 grams glucose load

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Men and women
• Ages 18 to 50 years
• Body mass index between 18.5 and 27.4 kilograms divided by squared meters
• Waist circumference ≤ 102 centimeters for men and ≤88 centimeters for women
• Fasting capillary glucose ≤100 milligrams per deciliter
• The night before the study:
• hours fasting
• Light dinner of their choice and repeat it every time before the study
• No alcohol, coffee or tea drinks the previous night
• No vigorous exercise the day before the test nor the morning of the test

You may not qualify if:

• Consumption of any of the following: oral hypoglycemic drugs, oral or parenteral glucocorticoid drugs, thyroid hormones, stimulant of intestinal motility or other drugs that may interfere with the intestinal absorption during the test
• Acute or chronic gastrointestinal infections
• Breast feeding or pregnant women
• Intestinal surgeries in the last 6 months
• Allergies to any of the products we will be using
• Subjects with gastrointestinal or metabolic diseases
• Subjects with first grade family history of diabetes mellitus
• Subjects with glucose intolerance, insulin resistance or diabetes mellitus
• Subjects who dislike any of the products we will be using
• Subjects with an acute (previous 24 hours) digestive crisis including: gastritis, diarrhea, and vomit, among others
• Subjects with a history of mal-absorption
• Suspension:
• Subjects that do not arrive at the test-day
• Fasting glucose ≥ 100 milligrams per deciliter the day of the test
• Subjects who develop gastrointestinal disease during the study time frame

Sponsors & Collaborators

• Instituto Tecnologico y de Estudios Superiores de Monterey: lead

Study Sites (1)

Clinical Nutrition and Obesity Research Center. School of Medicine and Health Sciences, TEC Salud, Tecnológico de Monterrey

Monterrey, Nuevo León, 64710, Mexico

Location

Related Publications (32)

• Brand JC, Holt S, Saveny and Hanksy J. Plasma glucose correlates inversely with satiety and CCK. Proc Nutr Soc Aust 1990; 15: 209 (abstr).

  BACKGROUND

• Brock DW, Davis CK, Irving BA, Rodriguez J, Barrett EJ, Weltman A, Taylor AG, Gaesser GA. A high-carbohydrate, high-fiber meal improves endothelial function in adults with the metabolic syndrome. Diabetes Care. 2006 Oct;29(10):2313-5. doi: 10.2337/dc06-0917. No abstract available.

  PMID: 17003313 BACKGROUND

• Brouns F, Bjorck I, Frayn KN, Gibbs AL, Lang V, Slama G, Wolever TM. Glycaemic index methodology. Nutr Res Rev. 2005 Jun;18(1):145-71. doi: 10.1079/NRR2005100.

  PMID: 19079901 BACKGROUND

• Carlson JJ, Eisenmann JC, Norman GJ, Ortiz KA, Young PC. Dietary fiber and nutrient density are inversely associated with the metabolic syndrome in US adolescents. J Am Diet Assoc. 2011 Nov;111(11):1688-95. doi: 10.1016/j.jada.2011.08.008.

  PMID: 22027051 BACKGROUND

• Carlson JJ, Monti V. The role of inclusive dietary patterns for achieving secondary prevention cardiovascular nutrition guidelines and optimal cardiovascular health. J Cardiopulm Rehabil. 2003 Sep-Oct;23(5):322-33. doi: 10.1097/00008483-200309000-00001. No abstract available.

  PMID: 14512776 BACKGROUND

• Carlson JJ, Winkleby M, Gardner C, Ahn D. Plant-based food intake and cardiovascular disease (CVD) risk factor status in a national sample of ethnically diverse women (NHANES III) FASEB J. 2003a;17:A372.

  BACKGROUND

• Delzenne NM, Cani PD. A place for dietary fibre in the management of the metabolic syndrome. Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):636-40. doi: 10.1097/01.mco.0000171124.06408.71.

  PMID: 16205465 BACKGROUND

• Dubnov-Raz G, Berry EM. The dietary treatment of obesity. Endocrinol Metab Clin North Am. 2008 Dec;37(4):873-86. doi: 10.1016/j.ecl.2008.08.002.

  PMID: 19026937 BACKGROUND

• Ellison JM, Stegmann JM, Colner SL, Michael RH, Sharma MK, Ervin KR, Horwitz DL. Rapid changes in postprandial blood glucose produce concentration differences at finger, forearm, and thigh sampling sites. Diabetes Care. 2002 Jun;25(6):961-4. doi: 10.2337/diacare.25.6.961.

  PMID: 12032099 BACKGROUND

• Estruch R, Martinez-Gonzalez MA, Corella D, Salas-Salvado J, Ruiz-Gutierrez V, Covas MI, Fiol M, Gomez-Gracia E, Lopez-Sabater MC, Vinyoles E, Aros F, Conde M, Lahoz C, Lapetra J, Saez G, Ros E; PREDIMED Study Investigators. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med. 2006 Jul 4;145(1):1-11. doi: 10.7326/0003-4819-145-1-200607040-00004.

  PMID: 16818923 BACKGROUND

• Granfeldt Y, Hagander B, Bjorck I. Metabolic responses to starch in oat and wheat products. On the importance of food structure, incomplete gelatinization or presence of viscous dietary fibre. Eur J Clin Nutr. 1995 Mar;49(3):189-99.

  PMID: 7774535 BACKGROUND

• Halton TL, Willett WC, Liu S, Manson JE, Albert CM, Rexrode K, Hu FB. Low-carbohydrate-diet score and the risk of coronary heart disease in women. N Engl J Med. 2006 Nov 9;355(19):1991-2002. doi: 10.1056/NEJMoa055317.

  PMID: 17093250 BACKGROUND

• Hatonen KA, Simila ME, Virtamo JR, Eriksson JG, Hannila ML, Sinkko HK, Sundvall JE, Mykkanen HM, Valsta LM. Methodologic considerations in the measurement of glycemic index: glycemic response to rye bread, oatmeal porridge, and mashed potato. Am J Clin Nutr. 2006 Nov;84(5):1055-61. doi: 10.1093/ajcn/84.5.1055.

  PMID: 17093157 BACKGROUND

• Hu FB. Diet and cardiovascular disease prevention the need for a paradigm shift. J Am Coll Cardiol. 2007 Jul 3;50(1):22-4. doi: 10.1016/j.jacc.2007.04.027. Epub 2007 Jun 18. No abstract available.

  PMID: 17601540 BACKGROUND

• Hu FB. Plant-based foods and prevention of cardiovascular disease: an overview. Am J Clin Nutr. 2003 Sep;78(3 Suppl):544S-551S. doi: 10.1093/ajcn/78.3.544S.

  PMID: 12936948 BACKGROUND

• Jenkins DJ, Wolever TM, Ocana AM, Vuksan V, Cunnane SC, Jenkins M, Wong GS, Singer W, Bloom SR, Blendis LM, et al. Metabolic effects of reducing rate of glucose ingestion by single bolus versus continuous sipping. Diabetes. 1990 Jul;39(7):775-81. doi: 10.2337/diab.39.7.775.

  PMID: 2191884 BACKGROUND

• Katcher HI, Legro RS, Kunselman AR, Gillies PJ, Demers LM, Bagshaw DM, Kris-Etherton PM. The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome. Am J Clin Nutr. 2008 Jan;87(1):79-90. doi: 10.1093/ajcn/87.1.79.

  PMID: 18175740 BACKGROUND

• Kromhout D, Menotti A, Kesteloot H, Sans S. Prevention of coronary heart disease by diet and lifestyle: evidence from prospective cross-cultural, cohort, and intervention studies. Circulation. 2002 Feb 19;105(7):893-8. doi: 10.1161/hc0702.103728. No abstract available.

  PMID: 11854133 BACKGROUND

• McCaffrey TA, Rennie KL, Kerr MA, Wallace JM, Hannon-Fletcher MP, Coward WA, Jebb SA, Livingstone MB. Energy density of the diet and change in body fatness from childhood to adolescence; is there a relation? Am J Clin Nutr. 2008 May;87(5):1230-7. doi: 10.1093/ajcn/87.5.1230.

  PMID: 18469244 BACKGROUND

• Newby PK, Muller D, Hallfrisch J, Qiao N, Andres R, Tucker KL. Dietary patterns and changes in body mass index and waist circumference in adults. Am J Clin Nutr. 2003 Jun;77(6):1417-25. doi: 10.1093/ajcn/77.6.1417.

  PMID: 12791618 BACKGROUND

• Olaiz-Fernández, G., Rivera-Dommarco, J., Shamah-Levy, T., Rojas, R., Villalpando-Hernández, S., Hernández-Avila, M. & Sepúlveda, J. (2006) Encuesta Nacional de Salud y Nutrición. Cuernavaca, México: Instituto Nacional de Salud Pública. Available at: http://www.insp.mx/images/stories/ENSANUT/Docs/Ensanut2006.pdf (Accessed on June 2011)

  BACKGROUND

• Pan Y, Pratt CA. Metabolic syndrome and its association with diet and physical activity in US adolescents. J Am Diet Assoc. 2008 Feb;108(2):276-86; discussion 286. doi: 10.1016/j.jada.2007.10.049.

  PMID: 18237576 BACKGROUND

• Rakel: Integrative Medicine, 2nd ed. Saunders, Elsevier, 2007.

  BACKGROUND

• Roberts CK, Liu S. Carbohydrate intake and obesity: an association that needs "refining". J Am Diet Assoc. 2009 Jul;109(7):1163-4. doi: 10.1016/j.jada.2009.04.016. No abstract available.

  PMID: 19559131 BACKGROUND

• Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fat, carbohydrate, and cardiovascular disease. Am J Clin Nutr. 2010 Mar;91(3):502-9. doi: 10.3945/ajcn.2008.26285. Epub 2010 Jan 20.

  PMID: 20089734 BACKGROUND

• Steffen LM, Jacobs DR Jr, Murtaugh MA, Moran A, Steinberger J, Hong CP, Sinaiko AR. Whole grain intake is associated with lower body mass and greater insulin sensitivity among adolescents. Am J Epidemiol. 2003 Aug 1;158(3):243-50. doi: 10.1093/aje/kwg146.

  PMID: 12882946 BACKGROUND

• Steffen LM, Jacobs DR Jr, Stevens J, Shahar E, Carithers T, Folsom AR. Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr. 2003 Sep;78(3):383-90. doi: 10.1093/ajcn/78.3.383.

  PMID: 12936919 BACKGROUND

• Wang Y, Beydoun MA. The obesity epidemic in the United States--gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev. 2007;29:6-28. doi: 10.1093/epirev/mxm007. Epub 2007 May 17.

  PMID: 17510091 BACKGROUND

• Weickert MO, Pfeiffer AF. Metabolic effects of dietary fiber consumption and prevention of diabetes. J Nutr. 2008 Mar;138(3):439-42. doi: 10.1093/jn/138.3.439.

  PMID: 18287346 BACKGROUND

• Wolever TM, Jenkins DJ, Jenkins AL, Josse RG. The glycemic index: methodology and clinical implications. Am J Clin Nutr. 1991 Nov;54(5):846-54. doi: 10.1093/ajcn/54.5.846.

  PMID: 1951155 BACKGROUND

• Wolever TM, Mehling C. High-carbohydrate-low-glycaemic index dietary advice improves glucose disposition index in subjects with impaired glucose tolerance. Br J Nutr. 2002 May;87(5):477-87. doi: 10.1079/BJNBJN2002568.

  PMID: 12010586 BACKGROUND

• Zehner, L and Zehner W. Mixtures of fructose, sucrose and lactose as a low-calorie bulk sweetener with reduced glycemic index. United States Patent 7560443, 2003.

  BACKGROUND

MeSH Terms

Conditions

Glucose Intolerance

Condition Hierarchy (Ancestors)

Hyperglycemia; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Leticia Elizondo-Montemayor, MD

  Clinical Nutrition and Obesity Research Center. TEC Salud, School of Medicine and Health Sciences. Instituto Tecnologico y de Estudios Superiores de Monterrey

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Study Record Dates

• First Submitted: August 23, 2013
• First Posted: August 28, 2013
• Study Start: August 1, 2013
• Primary Completion: October 1, 2013
• Study Completion: November 1, 2013
• Last Updated: September 4, 2014

Record last verified: 2014-09

Locations

ME (1)