Chest Physiotherapy and Lung Function in Primary Ciliary Dyskinesia

NCT01929356 | Recruiting

• 1 other identifier: UZLMB001
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

Primary ciliary dyskinesia (PCD) is a rare disease, caused by impairment of the motile cilia. Patients present with chronic upper and lower respiratory tract infections. The therapy is mainly supportive and based on that of cystic fibrosis. Chest physiotherapy is one of the cornerstones of the therapy, however the influence of chest physiotherapy on lung function (short term and long term) is not clear. For interpretation of longitudinal lung function data it is important to examine the short time effect of chest physiotherapy. We hypothesize that a session of chest physiotherapy improves lung function and that thus lung function tests must be performed in a standardized way.

Conditions

Primary Ciliary Dyskinesia

Keywords

lung function tests; chest physiotherapy

Outcome Measures

Primary Outcomes (1)

• Difference in FEV1 before and after treatment

  Lung function will be performed before a session of chest physiotherapy, and repeated 30 minutes after a chest physiotherapy session of 20 minutes with airway clearance techniques and use of PEP mask

  30 minutes

Secondary Outcomes (1)

• Difference in LCI before and after chest physiotherapy

  30 minutes

Study Arms (1)

chest physiotherapy

EXPERIMENTAL

session of 20 minutes chest physiotherapy with physiotherapist, use of airway clearance techniques, PEP (positive expiratory pressure) device

Procedure: Chest physiotherapy

Interventions

Chest physiotherapy PROCEDURE

20 minutes of chest physiotherapy by physiotherapist

chest physiotherapy

Eligibility Criteria

• Age: 6 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Primary ciliary dyskinesia
• able to perform spirometry and MBW (\>6 years)

You may not qualify if:

• acute exacerbation

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

University Hospital Gasthuisberg Leuven

Leuven, 3000, Belgium

RECRUITING

MeSH Terms

Conditions

Ciliary Motility Disorders

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Otorhinolaryngologic Diseases; Ciliopathies; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Genetic Diseases, Inborn

Study Officials

• Mieke Boon, MD

  research fellow

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mieke Boon, MD

CONTACT

+3216342589; mieke.boon@uzleuven.be

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 22, 2013
• First Posted: August 27, 2013
• Study Start: June 30, 2020
• Primary Completion: November 1, 2025
• Study Completion: November 1, 2025
• Last Updated: July 3, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)