Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery

NCT01927302 | Completed

• 2 other identifiers: P50P50DC012283
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 4

Brief Summary

The purpose of this study is to investigate the effects of treatment for specific language deficits in people with aphasia. In addition to language and cognitive measures, changes in brain function will also be gathered before and after the treatment is administered in order to track any changes resulting from receiving treatment.

Conditions

Aphasia; Dysgraphia; Anomia; Agrammatism; Stroke

Keywords

Aphasia; Dysgraphia; Anomia; Agrammatism; Stroke; Language Recovery; Treatment; Biomarkers of Recovery

Outcome Measures

Primary Outcomes (1)

• Change in language and cognitive abilities as a result of treatment

  Standard and non-standard measures of language and cognitive abilities will be gathered at baseline (week 0) to see if language deficits improve after treatment is administered (week 12).

  week 0 to week 12

Secondary Outcomes (3)

• Composite change in brain function as a result of treatment

  week 0 to week 12

• Maintenance of language and cognitive abilities as a result of treatment

  week 12 to week 24

• Maintenance of composite changes in brain function as a result of treatment

  week 12 to week 24

Study Arms (3)

Naming Deficits

EXPERIMENTAL

Language treatment will focus on improving naming deficits in people who have aphasia. An experimental group will receive treatment focusing on naming objects and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.

Behavioral: Treatment Focusing on Naming Objects; Behavioral: No Treatment

Spelling and/or Writing Deficits

EXPERIMENTAL

Language treatment will focus on improving writing and/or spelling deficits in people who have aphasia. An experimental group will receive treatment focusing on improving spelling abilities and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.

Behavioral: Treatment Focusing on Improving Spelling Abilities; Behavioral: No Treatment

Sentence Processing

EXPERIMENTAL

Language treatment will focus on improving sentence comprehension and production deficits in people who have aphasia. An experimental group will receive treatment focusing on improving sentence processing and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.

Behavioral: Treatment Focusing on Improving Sentence Processing; Behavioral: No Treatment

Interventions

Treatment Focusing on Naming Objects BEHAVIORAL

Treatment will be administered from week 0 until week 12.

Also known as: Language treatment

Naming Deficits

Treatment Focusing on Improving Spelling Abilities BEHAVIORAL

Treatment will be administered from week 0 until week 12.

Also known as: Language Treatment

Spelling and/or Writing Deficits

Treatment Focusing on Improving Sentence Processing BEHAVIORAL

Treatment will be administered from week 0 until week 12.

Also known as: Language Treatment

Sentence Processing

No Treatment BEHAVIORAL

No treatment will be administered.

Naming Deficits; Sentence Processing; Spelling and/or Writing Deficits

Eligibility Criteria

• Age: 35 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aphasia following a stroke
• Stoke was at least 1 year ago
• Medically stable
• Right-handed
• Normal or 'corrected to normal' vision and hearing
• English as primary language
• At least a high school education

You may not qualify if:

• History of neurological disease, head trauma, psychiatric disorders, alcoholism, or developmental speech, language, or learning disabilities

Sponsors & Collaborators

• Northwestern University: lead
• National Institute on Deafness and Other Communication Disorders (NIDCD): collaborator
• National Institutes of Health (NIH): collaborator

Study Sites (4)

Northwestern University

Chicago, Illinois, 60208, United States

Location

Johns Hopkins University

Baltimore, Maryland, 21218, United States

Location

Boston University

Boston, Massachusetts, 02215, United States

Location

Harvard University

Cambridge, Massachusetts, 02138, United States

Location

Related Publications (72)

• Walenski M, Europa E, Caplan D, Thompson CK. Neural networks for sentence comprehension and production: An ALE-based meta-analysis of neuroimaging studies. Hum Brain Mapp. 2019 Jun 1;40(8):2275-2304. doi: 10.1002/hbm.24523. Epub 2019 Jan 28.

  PMID: 30689268 BACKGROUND

• Kiran S, Thompson CK. Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges. Front Neurol. 2019 Apr 2;10:295. doi: 10.3389/fneur.2019.00295. eCollection 2019.

  PMID: 31001187 BACKGROUND

• Crinion J, Holland AL, Copland DA, Thompson CK, Hillis AE. Neuroimaging in aphasia treatment research: quantifying brain lesions after stroke. Neuroimage. 2013 Jun;73:208-14. doi: 10.1016/j.neuroimage.2012.07.044. Epub 2012 Jul 27.

  PMID: 22846659 BACKGROUND

• Kiran S, Ansaldo A, Bastiaanse R, Cherney LR, Howard D, Faroqi-Shah Y, Meinzer M, Thompson CK. Neuroimaging in aphasia treatment research: standards for establishing the effects of treatment. Neuroimage. 2013 Aug 1;76:428-35. doi: 10.1016/j.neuroimage.2012.10.011. Epub 2012 Oct 9.

  PMID: 23063559 BACKGROUND

• Meinzer M, Beeson PM, Cappa S, Crinion J, Kiran S, Saur D, Parrish T, Crosson B, Thompson CK; Neuroimaging in Aphasia Treatment Research Workshop. Neuroimaging in aphasia treatment research: consensus and practical guidelines for data analysis. Neuroimage. 2013 Jun;73:215-24. doi: 10.1016/j.neuroimage.2012.02.058. Epub 2012 Feb 24.

  PMID: 22387474 BACKGROUND

• Rapp B, Caplan D, Edwards S, Visch-Brink E, Thompson CK. Neuroimaging in aphasia treatment research: issues of experimental design for relating cognitive to neural changes. Neuroimage. 2013 Jun;73:200-7. doi: 10.1016/j.neuroimage.2012.09.007. Epub 2012 Sep 10.

  PMID: 22974976 BACKGROUND

• Ditges R, Barbieri E, Thompson CK, Weintraub S, Weiller C, Mesulam MM, Kummerer D, Schroter N, Musso M. German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia. Brain Sci. 2021 Apr 8;11(4):474. doi: 10.3390/brainsci11040474.

  PMID: 33918022 BACKGROUND

• Thompson CK. Neurocognitive Recovery of Sentence Processing in Aphasia. J Speech Lang Hear Res. 2019 Nov 22;62(11):3947-3972. doi: 10.1044/2019_JSLHR-L-RSNP-19-0219. Epub 2019 Nov 22.

  PMID: 31756151 BACKGROUND

• Schuchard J, Thompson CK. Implicit and explicit learning in individuals with agrammatic aphasia. J Psycholinguist Res. 2014 Jun;43(3):209-24. doi: 10.1007/s10936-013-9248-4.

  PMID: 23532578 BACKGROUND

• Wang H, Yoshida M, Thompson CK. Parallel functional category deficits in clauses and nominal phrases: The case of English agrammatism. J Neurolinguistics. 2014 Jan;27(1):75-102. doi: 10.1016/j.jneuroling.2013.09.001.

  PMID: 26379370 BACKGROUND

• Thompson CK, Faroqi-Shah Y, & Lee J. (2015). Models of sentence production. In: A. Hillis (Ed.). The handbook of adult language disorders: Integrating cognitive neuropsychology, neurology, and rehabilitation. Second Edition (pp. 328-354). New York: Psychology Press.

  BACKGROUND

• Thompson CK, Kielar A. (2014). Neural bases of sentence processing: evidence from neurolinguistic and neuroimaging studies. In M. Goldrick, V. Ferreira, & M. Miozzo (Eds.) The Oxford Handbook of Language Production (pp. 47-69). New York: Oxford University Press.

  BACKGROUND

• Thompson CK, Meltzer-Asscher, A. (2014). Neurocognitive mechanisms of verb argument structure processing. In Asaf Bachrach, Isabelle Roy and Linaea Stockall (Eds.) Structuring the Argument: Multidisciplinary research on verb argument structure (pp. 141-168). John Benjamins.

  BACKGROUND

• Iorga M, Higgins J, Caplan D, Zinbarg R, Kiran S, Thompson CK, Rapp B, Parrish TB. Predicting language recovery in post-stroke aphasia using behavior and functional MRI. Sci Rep. 2021 Apr 19;11(1):8419. doi: 10.1038/s41598-021-88022-z.

  PMID: 33875733 BACKGROUND

• Ingo C, Sui Y, Chen Y, Parrish TB, Webb AG, Ronen I. Parsimonious continuous time random walk models and kurtosis for diffusion in magnetic resonance of biological tissue. Front Phys. 2015 Mar;3:11. doi: 10.3389/fphy.2015.00011. Epub 2015 Mar 16.

  PMID: 28344972 BACKGROUND

• Alpert K, Kogan A, Parrish T, Marcus D, Wang L. The Northwestern University Neuroimaging Data Archive (NUNDA). Neuroimage. 2016 Jan 1;124(Pt B):1131-1136. doi: 10.1016/j.neuroimage.2015.05.060. Epub 2015 May 30.

  PMID: 26032888 BACKGROUND

• Ingo C, Magin RL, Parrish TB. New Insights into the Fractional Order Diffusion Equation Using Entropy and Kurtosis. Entropy (Basel). 2014 Nov;16(11):5838-5852. doi: 10.3390/e16115838. Epub 2014 Nov 6.

  PMID: 28344436 BACKGROUND

• Meier EL, Johnson JP, Pan Y, Kiran S. The utility of lesion classification in predicting language and treatment outcomes in chronic stroke-induced aphasia. Brain Imaging Behav. 2019 Dec;13(6):1510-1525. doi: 10.1007/s11682-019-00118-3.

  PMID: 31093842 BACKGROUND

• Gilmore N, Meier EL, Johnson JP, Kiran S. Nonlinguistic Cognitive Factors Predict Treatment-Induced Recovery in Chronic Poststroke Aphasia. Arch Phys Med Rehabil. 2019 Jul;100(7):1251-1258. doi: 10.1016/j.apmr.2018.12.024. Epub 2019 Jan 9.

  PMID: 30639272 BACKGROUND

• Gilmore N, Meier EL, Johnson JP, Kiran S. Typicality-based semantic treatment for anomia results in multiple levels of generalisation. Neuropsychol Rehabil. 2020 Jun;30(5):802-828. doi: 10.1080/09602011.2018.1499533. Epub 2018 Jul 20.

  PMID: 30027828 BACKGROUND

• Meier EL, Johnson JP, Kiran S. Left frontotemporal effective connectivity during semantic feature judgments in patients with chronic aphasia and age-matched healthy controls. Cortex. 2018 Nov;108:173-192. doi: 10.1016/j.cortex.2018.08.006. Epub 2018 Aug 27.

  PMID: 30243049 BACKGROUND

• Meier EL, Johnson JP, Villard S, Kiran S. Does Naming Therapy Make Ordering in a Restaurant Easier? Dynamics of Co-Occurring Change in Cognitive-Linguistic and Functional Communication Skills in Aphasia. Am J Speech Lang Pathol. 2017 May 17;26(2):266-280. doi: 10.1044/2016_AJSLP-16-0028.

  PMID: 28196373 BACKGROUND

• Meier EL, Kapse KJ, Kiran S. The Relationship between Frontotemporal Effective Connectivity during Picture Naming, Behavior, and Preserved Cortical Tissue in Chronic Aphasia. Front Hum Neurosci. 2016 Mar 16;10:109. doi: 10.3389/fnhum.2016.00109. eCollection 2016.

  PMID: 27014039 BACKGROUND

• Meier EL, Lo M, Kiran S. Understanding semantic and phonological processing deficits in adults with aphasia: Effects of category and typicality. Aphasiology. 2016;30(6):719-749. doi: 10.1080/02687038.2015.1081137. Epub 2015 Sep 12.

  PMID: 27041784 BACKGROUND

• Kiran S, Meier EL, Kapse KJ, Glynn PA. Changes in task-based effective connectivity in language networks following rehabilitation in post-stroke patients with aphasia. Front Hum Neurosci. 2015 Jun 9;9:316. doi: 10.3389/fnhum.2015.00316. eCollection 2015.

  PMID: 26106314 BACKGROUND

• Vallila-Rohter S, Kiran S. (2015). Diagnosis and Treatment of Semantic Impairments. In A. Hillis (Ed.) Handbook on Adult Language Disorders. Taylor & Francis/Psychology Press of 711 Third Avenue, 8th Floor, New York, NY 10017.

  BACKGROUND

• Breining B, Rapp B. Investigating the mechanisms of written word production: Insights from the written blocked cyclic naming paradigm. Read Writ. 2019 Jan;32(1):65-94. doi: 10.1007/s11145-017-9742-4. Epub 2017 Apr 12.

  PMID: 30686861 BACKGROUND

• Ellenblum G, Purcell JJ, Song X, Rapp B. High-level Integrative Networks: A Resting-state fMRI Investigation of Reading and Spelling. J Cogn Neurosci. 2019 Jul;31(7):961-977. doi: 10.1162/jocn_a_01405. Epub 2019 Apr 2.

  PMID: 30938593 BACKGROUND

• Rapp B, Wiley RW. Re-learning and remembering in the lesioned brain. Neuropsychologia. 2019 Sep;132:107126. doi: 10.1016/j.neuropsychologia.2019.107126. Epub 2019 Jun 19.

  PMID: 31226267 BACKGROUND

• Tao Y, Rapp B. The effects of lesion and treatment-related recovery on functional network modularity in post-stroke dysgraphia. Neuroimage Clin. 2019;23:101865. doi: 10.1016/j.nicl.2019.101865. Epub 2019 May 22.

  PMID: 31146116 BACKGROUND

• Wiley RW, Rapp B. From complexity to distinctiveness: The effect of expertise on letter perception. Psychon Bull Rev. 2019 Jun;26(3):974-984. doi: 10.3758/s13423-018-1550-6.

  PMID: 30478777 BACKGROUND

• Purcell JJ, Rapp B. Local response heterogeneity indexes experience-based neural differentiation in reading. Neuroimage. 2018 Dec;183:200-211. doi: 10.1016/j.neuroimage.2018.07.063. Epub 2018 Aug 1.

  PMID: 30076891 BACKGROUND

• Hepner C, McCloskey M, Rapp B. Do reading and spelling share orthographic representations? Evidence from developmental dysgraphia. Cogn Neuropsychol. 2017 May-Jun;34(3-4):119-143. doi: 10.1080/02643294.2017.1375904. Epub 2017 Sep 21.

  PMID: 28934055 BACKGROUND

• McCloskey M, Rapp B. Developmental dysgraphia: An overview and framework for research. Cogn Neuropsychol. 2017 May-Jun;34(3-4):65-82. doi: 10.1080/02643294.2017.1369016. Epub 2017 Sep 14.

  PMID: 28906176 BACKGROUND

• Rothlein D, Rapp B. The role of allograph representations in font-invariant letter identification. J Exp Psychol Hum Percept Perform. 2017 Jul;43(7):1411-1429. doi: 10.1037/xhp0000384. Epub 2017 Apr 3.

  PMID: 28368166 BACKGROUND

• Breining B, Nozari N, Rapp B. Does segmental overlap help or hurt? Evidence from blocked cyclic naming in spoken and written production. Psychon Bull Rev. 2016 Apr;23(2):500-6. doi: 10.3758/s13423-015-0900-x.

  PMID: 26179140 BACKGROUND

• Nozari N, Freund M, Breining B, Rapp B, Gordon B. Cognitive control during selection and repair in word production. Lang Cogn Neurosci. 2016;31(7):886-903. doi: 10.1080/23273798.2016.1157194. Epub 2016 Apr 14.

  PMID: 28133620 BACKGROUND

• Wiley RW, Wilson C, Rapp B. The effects of alphabet and expertise on letter perception. J Exp Psychol Hum Percept Perform. 2016 Aug;42(8):1186-203. doi: 10.1037/xhp0000213. Epub 2016 Feb 25.

  PMID: 26913778 BACKGROUND

• Rapp B, Purcell J, Hillis AE, Capasso R, Miceli G. Neural bases of orthographic long-term memory and working memory in dysgraphia. Brain. 2016 Feb;139(Pt 2):588-604. doi: 10.1093/brain/awv348. Epub 2015 Dec 17.

  PMID: 26685156 BACKGROUND

• Nickels L, Rapp B, Kohnen S. Challenges in the use of treatment to investigate cognition. Cogn Neuropsychol. 2015;32(3-4):91-103. doi: 10.1080/02643294.2015.1056652.

  PMID: 26377505 BACKGROUND

• Rapp B, Fischer-Baum S, Miozzo M. Modality and morphology: what we write may not be what we say. Psychol Sci. 2015 Jun;26(6):892-902. doi: 10.1177/0956797615573520. Epub 2015 Apr 29.

  PMID: 25926478 BACKGROUND

• Purcell JJ, Shea J, Rapp B. Beyond the visual word form area: the orthography-semantics interface in spelling and reading. Cogn Neuropsychol. 2014;31(5-6):482-510. doi: 10.1080/02643294.2014.909399. Epub 2014 May 16.

  PMID: 24833190 BACKGROUND

• Fischer-Baum S, Rapp B. The analysis of perseverations in acquired dysgraphia reveals the internal structure of orthographic representations. Cogn Neuropsychol. 2014;31(3):237-65. doi: 10.1080/02643294.2014.880676. Epub 2014 Feb 5.

  PMID: 24499188 BACKGROUND

• Rothlein D, Rapp B. The similarity structure of distributed neural responses reveals the multiple representations of letters. Neuroimage. 2014 Apr 1;89:331-44. doi: 10.1016/j.neuroimage.2013.11.054. Epub 2013 Dec 7.

  PMID: 24321558 BACKGROUND

• Tainturier MJ, Bosse ML, Roberts DJ, Valdois S, Rapp B. Lexical neighborhood effects in pseudoword spelling. Front Psychol. 2013 Nov 28;4:862. doi: 10.3389/fpsyg.2013.00862. eCollection 2013.

  PMID: 24348436 BACKGROUND

• Purcell JJ, Rapp B. Identifying functional reorganization of spelling networks: an individual peak probability comparison approach. Front Psychol. 2013 Dec 25;4:964. doi: 10.3389/fpsyg.2013.00964. eCollection 2013.

  PMID: 24399981 BACKGROUND

• Dufor O, Rapp B. Letter representations in writing: an fMRI adaptation approach. Front Psychol. 2013 Oct 28;4:781. doi: 10.3389/fpsyg.2013.00781. eCollection 2013.

  PMID: 24194724 BACKGROUND

• Rapp B, Damian M. (2018). From thought to action: Producing written language. In, Rueschemeyer, S.A & Gaskell, G. (Eds.) Oxford Handbook of Psycholinguistics. Oxford University Press.

  BACKGROUND

• Nickels L, Kohnen S, Rapp B. (Eds.). (2018). Treatment as a tool for investigating cognition. Psychology Press.

  BACKGROUND

• Rapp B, Purcell J. (2017). Understanding how we produce written words: Lessons from the brain. In, De Zubicaray, G. and Schiller, N.O. (Eds.) Oxford Handbook of Neurolinguistics. Oxford University Press.

  BACKGROUND

• Rapp B, Fischer-Baum S. (2014). Representation of orthographic knowledge. In Ferreira, Goldrick and Miozzo (Eds.) Oxford Handbook on Language Production. Oxford University Press.

  BACKGROUND

• Riley EA, Thompson CK. Training Pseudoword Reading in Acquired Dyslexia: A Phonological Complexity Approach. Aphasiology. 2015 Feb 1;29(2):129-150. doi: 10.1080/02687038.2014.955389.

  PMID: 26085708 BACKGROUND

• Lee J, Yoshida M, Thompson CK. Grammatical Planning Units During Real-Time Sentence Production in Speakers With Agrammatic Aphasia and Healthy Speakers. J Speech Lang Hear Res. 2015 Aug;58(4):1182-94. doi: 10.1044/2015_JSLHR-L-14-0250.

  PMID: 25908309 BACKGROUND

• Wang H, Thompson CK. Assessing Syntactic Deficits in Chinese Broca's aphasia using the Northwestern Assessment of Verbs and Sentences-Chinese (NAVS-C). Aphasiology. 2016;30(7):815-840. doi: 10.1080/02687038.2015.1111995. Epub 2015 Nov 16.

  PMID: 27453620 BACKGROUND

• Cho-Reyes S, Mack JE, Thompson CK. Grammatical Encoding and Learning in Agrammatic Aphasia: Evidence from Structural Priming. J Mem Lang. 2016 Dec;91:202-218. doi: 10.1016/j.jml.2016.02.004. Epub 2016 Mar 21.

  PMID: 28924328 BACKGROUND

• Mack JE, Nerantzini M, Thompson CK. Recovery of Sentence Production Processes Following Language Treatment in Aphasia: Evidence from Eyetracking. Front Hum Neurosci. 2017 Mar 13;11:101. doi: 10.3389/fnhum.2017.00101. eCollection 2017.

  PMID: 28348524 BACKGROUND

• Mack JE, Thompson CK. Recovery of Online Sentence Processing in Aphasia: Eye Movement Changes Resulting From Treatment of Underlying Forms. J Speech Lang Hear Res. 2017 May 24;60(5):1299-1315. doi: 10.1044/2016_JSLHR-L-16-0108.

  PMID: 28474086 BACKGROUND

• Barbieri E, Mack J, Chiappetta B, Europa E, Thompson CK. Recovery of offline and online sentence processing in aphasia: Language and domain-general network neuroplasticity. Cortex. 2019 Nov;120:394-418. doi: 10.1016/j.cortex.2019.06.015. Epub 2019 Jul 13.

  PMID: 31419597 RESULT

• Thompson CK, Walenski M, Chen Y, Caplan D, Kiran S, Rapp B, Grunewald K, Nunez M, Zinbarg R, Parrish TB. Intrahemispheric Perfusion in Chronic Stroke-Induced Aphasia. Neural Plast. 2017;2017:2361691. doi: 10.1155/2017/2361691. Epub 2017 Mar 5.

  PMID: 28357141 RESULT

• Lukic S, Barbieri E, Wang X, Caplan D, Kiran S, Rapp B, Parrish TB, Thompson CK. Right Hemisphere Grey Matter Volume and Language Functions in Stroke Aphasia. Neural Plast. 2017;2017:5601509. doi: 10.1155/2017/5601509. Epub 2017 May 9.

  PMID: 28573050 RESULT

• Lukic S, Thompson CK, Barbieri E, Chiappetta B, Bonakdarpour B, Kiran S, Rapp B, Parrish TB, Caplan D. Common and distinct neural substrates of sentence production and comprehension. Neuroimage. 2021 Jan 1;224:117374. doi: 10.1016/j.neuroimage.2020.117374. Epub 2020 Sep 17.

  PMID: 32949711 RESULT

• Higgins J, Barbieri E, Wang X, Mack J, Caplan D, Kiran S, Rapp B, Thompson C, Zinbarg R, Parrish T. Reliability of BOLD signals in chronic stroke-induced aphasia. Eur J Neurosci. 2020 Oct;52(8):3963-3978. doi: 10.1111/ejn.14739. Epub 2020 Apr 28.

  PMID: 32282965 RESULT

• Europa E, Gitelman DR, Kiran S, Thompson CK. Neural Connectivity in Syntactic Movement Processing. Front Hum Neurosci. 2019 Feb 13;13:27. doi: 10.3389/fnhum.2019.00027. eCollection 2019.

  PMID: 30814941 RESULT

• Lukic S, Meltzer-Asscher A, Higgins J, Parrish TB, Thompson CK. Neurocognitive correlates of category ambiguous verb processing: The single versus dual lexical entry hypotheses. Brain Lang. 2019 Jul;194:65-76. doi: 10.1016/j.bandl.2019.04.005. Epub 2019 May 16.

  PMID: 31103888 RESULT

• Hsu CJ, Thompson CK. Manual Versus Automated Narrative Analysis of Agrammatic Production Patterns: The Northwestern Narrative Language Analysis and Computerized Language Analysis. J Speech Lang Hear Res. 2018 Feb 15;61(2):373-385. doi: 10.1044/2017_JSLHR-L-17-0185.

  PMID: 29411008 RESULT

• Thompson CK. Single subject controlled experiments in aphasia: the science and the state of the science. J Commun Disord. 2006 Jul-Aug;39(4):266-91. doi: 10.1016/j.jcomdis.2006.02.003. Epub 2006 Apr 25.

  PMID: 16635494 RESULT

• Mack JE, Meltzer-Asscher A, Barbieri E, Thompson CK. Neural correlates of processing passive sentences. Brain Sci. 2013 Aug 2;3(3):1198-214. doi: 10.3390/brainsci3031198.

  PMID: 24961525 RESULT

• Meltzer-Asscher A, Mack JE, Barbieri E, Thompson CK. How the brain processes different dimensions of argument structure complexity: evidence from fMRI. Brain Lang. 2015 Mar;142:65-75. doi: 10.1016/j.bandl.2014.12.005. Epub 2015 Feb 4.

  PMID: 25658635 RESULT

• Schuchard J, Nerantzini M, Thompson CK. Implicit learning and implicit treatment outcomes in individuals with aphasia. Aphasiology. 2017;31(1):25-48. doi: 10.1080/02687038.2016.1147526. Epub 2016 Feb 19.

  PMID: 28603329 RESULT

• Mack JE, Wei AZ, Gutierrez S, Thompson CK. Tracking sentence comprehension: Test-retest reliability in people with aphasia and unimpaired adults. J Neurolinguistics. 2016 Nov;40:98-111. doi: 10.1016/j.jneuroling.2016.06.001. Epub 2016 Jun 24.

  PMID: 27867260 RESULT

• Schuchard J, Thompson CK. Sequential learning in individuals with agrammatic aphasia: evidence from artificial grammar learning. J Cogn Psychol (Hove). 2017;29(5):521-534. doi: 10.1080/20445911.2017.1293065. Epub 2017 Feb 17.

  PMID: 28690782 RESULT

• Johnson JP, Meier EL, Pan Y, Kiran S. Treatment-related changes in neural activation vary according to treatment response and extent of spared tissue in patients with chronic aphasia. Cortex. 2019 Dec;121:147-168. doi: 10.1016/j.cortex.2019.08.016. Epub 2019 Sep 19.

  PMID: 31627014 DERIVED

Related Links

• Boston University's Aphasia Research Laboratory
• Johns Hopkins University's CogNeuro Research Laboratory

MeSH Terms

Conditions

Aphasia; Agraphia; Anomia; Aphasia, Broca; Stroke

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Specific Learning Disorder; Learning Disabilities; Neurodevelopmental Disorders; Mental Disorders; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Cynthia K Thompson, PhD

  Northwestern University

  STUDY DIRECTOR

• David Caplan, MDCM, PhD

  Harvard University Massachusetts General Hospital

  PRINCIPAL INVESTIGATOR

• Brenda Rapp, PhD

  Johns Hopkins University

  PRINCIPAL INVESTIGATOR

• Swathi Kiran, PhD, CCC-SLP

  Boston University

  PRINCIPAL INVESTIGATOR

• Todd B Parrish, PhD

  Northwestern University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ralph and Jean Sundin Professor of Communication Sciences

Study Record Dates

• First Submitted: July 29, 2013
• First Posted: August 22, 2013
• Study Start: April 1, 2013
• Primary Completion: March 27, 2019
• Study Completion: March 27, 2019
• Last Updated: August 11, 2021

Record last verified: 2021-08

Locations

US (4)