Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes

NCT01926938 | Completed DMC

• 1 other identifier: CHS#: 03-30
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with diabetes. Endothelial function and vascular reactivity are impaired not only in white adults with type 2 diabetes but also in those at risk for the disease by virtue of having impaired glucose tolerance or parental history of type 2 diabetes. Whether this finding is applicable to hispanics is not known. The investigators plan to assess the endothelial function and vascular reactivity in young Hispanic adults at risk of developing type 2 diabetes by virtue of being obese and belonging to a minority population.

Conditions

Obesity; Insulin Resistance

Outcome Measures

Primary Outcomes (1)

• markers of endothelial activation, coagulation and inflammation

  cross sectional evaluation

Study Arms (2)

adults at risk

Latino adults with family history of type 2 diabetes

controls

Latino adults without family history of type 2 diabetes and normal glucose tolerance

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Young Latino adults with and without family history of type 2 diabetes

You may qualify if:

• Group 1:
• Age between 18-40 years;
• Hispanic (we will consider a subject being Hispanic if both parents are reported as Hispanics when asked the following question: "What ethnic group do you consider that you belong to?");
• History of type 2 diabetes in one or both parents;
• BMI above 27;
• Not have participated in any exercise program for the 6 months prior to the beginning of the study.
• Group 2:
• Age between 18-40 years;
• Hispanic (same criteria as above );
• No history of type 2 diabetes in any first degree relative;
• BMI under 25;
• Not have participated in any exercise program for the 6 months prior to the beginning of the study.

You may not qualify if:

• diabetes, glucose intolerance, pregnancy, smoking, cardiovascular disease, uncontrolled hypertension, renal disease, proteinuria, cancer, infectious diseases, severe GI diseases, lung disease, electrolyte abnormalities, anemia, endocrine disorders, severe dyslipidemia, peripheral vascular disease, medications: beta-blockers, any diuretic, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, niacin, glucocorticoids, any antineoplastic agent, antibiotics, psychoactive agents, bronchodilators or insulin.

Sponsors & Collaborators

• Joslin Diabetes Center: lead

Study Sites (1)

Joslin Diabetes Center

Boston, Massachusetts, 02215, United States

Location

MeSH Terms

Conditions

Obesity; Insulin Resistance

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Officials

• Enrique Caballero, MD

  Joslin Diabetes Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Investigator/Director, Latino Diabetes Initiative

Study Record Dates

• First Submitted: August 19, 2013
• First Posted: August 21, 2013
• Study Start: May 1, 2003
• Primary Completion: January 1, 2013
• Study Completion: January 1, 2013
• Last Updated: August 21, 2013

Record last verified: 2013-08

Locations

US (1)