Aerobic Exercise in Children With Moderate and Severe Asthma

NCT01920529 | Completed

• 2 other identifiers: livia1971EASMADOC2013
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Regular aerobic physical activity in short-term moderate asthma and severe:

• Reduce the levels of inflammatory mediators
• Improves functional capacity
• Improves Quality of Life
• Improved lung function
• Reduces the sensation of dyspnea
• Improves symptoms scores and medication use

Conditions

Asthma

Keywords

asthma, aerobic exercise, child, cytokines

Outcome Measures

Primary Outcomes (1)

• Inflammatory mediators by analyzing cytokines by flow cytometry

  Was carried collection of peripheral blood cells separated and analyzed for cytokine flow cytometry method. We evaluated Th1 and Th2 cytokines.

  six weeks

Secondary Outcomes (5)

• Distance walked during the 6-minute walk

  6 weeks

• Changes in lung function

  Before and after 6 weeks of intervention

• Days free of asthma

  After six weeks

• Respiratory pressures maxima

  Before and after 6 weeks

• Analysis of cytokines

  Before and after 6 weeks

Study Arms (2)

aerobic exercise

EXPERIMENTAL

The study will consist of two groups: Group Comparison (GC) will be submitted to two evaluations at the beginning of a week and end of 6 weeks, without receiving any kind of physical training intervention. Group Training (GT) will undergo two assessments at the beginning of the end of the 1st and 6th week, however will be submitted to aerobic training for six weeks. Supervised aerobic training will be held three times a week for six weeks,treadmill in four consecutive steps each (05 minutes stretching, 05 minutes heating, 20 training minutes (1 st and 2 nd week) and 30 minutes (3 rd to 6 weeks) and cool down 05 minutes). The exercise intensity will be maintained through a desired percentage of heart rate for training (x%) from 70% to 80%, obtaining then the optimal heart rate training.

Other: aerobic exercise

control

PLACEBO COMPARATOR

Investigators evaluated the distance walked during the 6-minute walk test and recorded variables such as heart rate, respiratory frequency, pulse oxygen saturation and a scale of perceived exertion (Borg) in the moments before and after the test. There was only evaluation without intervention.

Other: aerobic exercise

Interventions

aerobic exercise OTHER

Performed aerobic exercise on a treadmill with cardiac predetermined frequency within 6 weeks and frequency of three times per week. All patients were monitored during training.

Also known as: physical exercise, physical training

aerobic exercise; control

Eligibility Criteria

• Age: 8 Years - 19 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age greater than eight and less than nineteen years
• Diagnosis of moderate to severe persistent asthma according to criteria of GINA
• forced expiratory volume in one minute (FEV1) below 80% of predicts
• Initiation of treatment with inhaled corticosteroids for at least eight weeks before the start of collection.

You may not qualify if:

• associated disease that limits physical activity, such as neuromuscular disease, congenital or acquired, severe cor pulmonate, severe congenital malformation
• associated with chronic lung disease (cystic fibrosis, bronchiectasis, bronchopulmonary dysplasia, interstitial lung diseases
• significant cognitive deficit, which makes the participant to respond adequately to the questionnaire and / or failure to meet the commands
• mental deficit.

Sponsors & Collaborators

• Instituto Materno Infantil Prof. Fernando Figueira: lead

Study Sites (1)

Integral Medicine Institute Professor. Fernando Figueira-IMIP

Recife, Pernambuco, 50070550, Brazil

Location

MeSH Terms

Conditions

Asthma

Interventions

Exercise

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Livia B Andrade, PhD student

  Professor of Pediatric Physical Therapy Specialization of integral medicine institute Prof. Fernando Figueira

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Student

Study Record Dates

• First Submitted: May 13, 2013
• First Posted: August 12, 2013
• Study Start: August 1, 2011
• Primary Completion: March 1, 2013
• Study Completion: March 1, 2013
• Last Updated: August 12, 2013

Record last verified: 2013-08

Locations

BR (1)