NCT01916642|CompletedPhase 1
A Dose-response Study of Lidocaine and Etomidate
Can Intravenous Lidocaine Decrease the Minimal Inducing Dose of Etomidate?: A Randomized Placebo-controlled Dose-response Study.
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Can Intravenous Lidocaine Decrease the Minimal Inducing Dose of Etomidate?: A Randomized Placebo-controlled Dose-response Study.
Sponsor study identifier
interventional
100
0 countries
N/A
Study Start
April 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2013
Actual (reported)Study Completion
July 2013
Actual (reported)IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2013
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2013
Date type not reportedThis date has not been verified as actual or estimated.
June 2013
Actual (reported)July 2013
Actual (reported)July 23, 2013
Actual (reported)August 5, 2013
Actual (reported)changes in blood pressure and heart rate.
6 weeks
0.9% Normal Saline is given instead of Lidocaine in the same volume and duration. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Lidocaine 1mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Lidocaine 1.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
The total dosage of Etomidate needed for induction of anesthesia is recorded at last.
same as other
Liu Jin, MD
West China Hospital
100 participants (actual enrollment reported by the registry).
First Submitted
July 23, 2013
First Posted
August 5, 2013
Study Start
April 2013
Date type not reportedThis date has not been verified as actual or estimated.
Lidocaine 2mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Lidocaine 2.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
same as other
same as other
Contact the study team to confirm eligibility.
Primary Completion
June 2013
Actual (reported)Study Completion
July 2013
Actual (reported)Last Updated
August 5, 2013
Record last verified: 2013-08
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Source: ClinicalTrials.gov.
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