Magnetic Resonance Imaging Study of Acute Pancreatitis

NCT01911689 | Completed Results DMC

• 1 other identifier: SKLMC-2013-001
• Study Type: observational
• Target: 168
• Locations: 1 country
• Sites: 1

Brief Summary

To quantitatively analyze the T2\* values of the head, body, and tail of normal pancreas, and observe the value of GRE T2\*-weighted MRI in the diagnosis of acute pancreatitis and the relationship between the T2\* value and the severity of AP.

Conditions

Acute Pancreatitis

Keywords

pancreatitis; MRI; APACHEⅡ; T2*; T2 star

Outcome Measures

Primary Outcomes (1)

• The T2* Values in the Diagnosis of AP

  Compare the difference of the T2\* value between the AP group and the control group.

  1 year

Secondary Outcomes (3)

• The Difference of T2* Value Between the Edematous AP and Necrotizing AP

  1 year

• The T2* Value in Different Severity of AP According to MRSI

  1 year

• The Relationship Between the T2* Value and the Severity of AP According to Apache II

  1 year

Study Arms (2)

acute pancreatitis

acute pancreatitis group：(a) acute onset of abdominal pain; (b) pancreatitis at first onset; (c) three-fold elevated amylase or lipase, excluding other causes of elevated enzymes; and (5) abdominal MR examination.

controlgroup

normal control group：without pancreatic disorders.The exclusion criteria in this study were as follows: (a) inability to cooperate when MR imaging was performed; (b) a history of chronic pancreatitis; (c) AP due to pancreatic carcinoma; (d) hypoproteinemia; and (e) with hypoproteinemia and other peritoneal/ retroperitoneal infection diseases ;(f) with iron deposition disorder (e.g. diabetes or blood system diseases).

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with AP admitted to our institution between August 2013 and March 2015 were considered for inclusion in this study. The inclusion criteria for patients in this study were as follows: (a) acute onset of abdominal pain; (b) pancreatitis at first onset; (c) three-fold elevated amylase or lipase, excluding other causes of elevated enzymes; and (d) abdominal MR examination.

You may qualify if:

• acute onset of abdominal pain;
• pancreatitis at first onset;
• three-fold elevated amylase or lipase, excluding other causes of elevated enzymes; and
• abdominal MR examination.

You may not qualify if:

• inability to cooperate when MR imaging was performed;
• a history of chronic pancreatitis;
• AP due to pancreatic carcinoma;
• hypoproteinemia;
• with hypoproteinemia and other peritoneal/ retroperitoneal infection diseases ;
• with iron deposition disorder (e.g. diabetes or blood system diseases).

Sponsors & Collaborators

• Affiliated Hospital of North Sichuan Medical College: lead

Study Sites (1)

Affiliated Hospital of North Sichuan Medical College

Nanchong, Sichuan, 637000, China

Location

MeSH Terms

Conditions

Pancreatitis

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases

Limitations and Caveats

Some diseases, such as chronic anemia, diabetes, etc., may lead to iron deposition in pancreas and may lead to change the T2\* value.

Results Point of Contact

• Title: Dr.XiaoMing Zhang
• Organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College

cjr.zhxm@vip.163.com

+86 817 2262218

Study Officials

• zhang x ming, PHD

  Affiliated Hospital of North Sichuan Medical College

  STUDY CHAIR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 26, 2013
• First Posted: July 30, 2013
• Study Start: August 1, 2013
• Primary Completion: March 1, 2015
• Study Completion: March 1, 2015
• Last Updated: August 24, 2015
• Results First Posted: August 24, 2015

Record last verified: 2014-11

Locations

CN (1)