Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men

NCT01905345 | Completed

• 1 other identifier: REGPOT
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Randomised training intervention. Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell Sarcopenia Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible. Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.

Conditions

Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation

Outcome Measures

Primary Outcomes (1)

• Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes

  Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain \[um\^2\], myonuclear number \[%\] in response to consecutive training regimes

  participants will be followed for the duration of training period, an expected average of 7 months

Study Arms (3)

Endurance and Resistance Training

EXPERIMENTAL

Endurance and resistance exercise

Procedure: Training

Resistance Training

EXPERIMENTAL

resistance exercise (12wk)

Procedure: Training

Resistance and resistance Training

EXPERIMENTAL

resistance exercise (24 wk)

Procedure: Training

Interventions

Training PROCEDURE

Endurance and Resistance Training; Resistance Training; Resistance and resistance Training

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• no fever at the beginning and during the study
• between 60 years and 75 years
• non smokers
• no known cardiovascular and orthopaedic problems
• no cardiac pacemaker
• fulfilling the health criteria

You may not qualify if:

• fever or cold at the beginning or during the study
• non MRI compatible metal implants
• under 60 years or over 75 years
• smoker
• cardiovascular or orthopaedic problems
• cardiac pacemaker
• not fulfilling the health criteria

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zurich, Division of Neurology

Zurich, Canton of Zurich, 8091, Switzerland

Location

Study Officials

• Hans H Jung, Prof MD

  University Hospital Zurich, Division of Neurology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 16, 2013
• First Posted: July 23, 2013
• Study Start: August 1, 2013
• Primary Completion: December 1, 2015
• Study Completion: August 1, 2017
• Last Updated: August 7, 2017

Record last verified: 2017-08

Locations

CH (1)