Study of the Telomere-telomerase System and the Expression of Candidate Genes in the Leukocytes of Patients With Depressive Disorder: Search for Peripheral Markers of Somatic Stress

NCT01903655 | Completed

• 1 other identifier: Chauvet PHRC IR 2009
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The mechanisms of oxidative stress and inflammation involved in mood disorders are factors of chronicity and severity. These mechanisms induce a phenomenon of accelerated cellular senescence and are reflected by alterations in systemic gene expression detectable in leukocytes in peripheral blood. The genetic markers of these mechanisms are clinically significant markers. The identification of new genetic markers will make it possible to improve evaluations of the severity and somatic consequences of depressive syndromes.

Conditions

Depressive Disorder

Outcome Measures

Primary Outcomes (1)

• Telomere length

  participants will be followed for the duration of hospital stay, an expected average of 6 months

Secondary Outcomes (1)

• level of oxidative stress.

  participants will be followed for the duration of hospital stay, an expected average of 6 months

Study Arms (3)

patients with a first episode of major depressive disorder

OTHER

a group of patients with a first episode of major depressive disorder according to DSM-IV-TR including depressive episodes with melancholic features

Other: telomere length

patients with recurrent depressive disorder

OTHER

a group of patients with recurrent depressive disorder according to DSM-IV-TR including depressive episodes with melancholic features (at least three episodes of depression)

Other: telomere length

control group

OTHER

patient with no depressive disorder during the study period and no psychiatric history

Other: telomere length

Interventions

telomere length OTHER

control group; patients with a first episode of major depressive disorder; patients with recurrent depressive disorder

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Persons who have given their written informed consent
• absence of a diagnosis of major depressive disorder throughout the study and no history of psychiatric disorders
• diagnosis of a first episode of a major depressive disorder
• diagnosis of a recurrent major depressive disorder (at least three episodes) with or without resistance to therapy
• Remarks:
• the diagnosis of major depressive disorder with characteristics of melancholy must be clearly mentioned in the case report form but is not a reason for not being included in the study
• the presence of a recent or older attempted suicide must lead to a careful clinical assessment of the diagnosis of depressive disorder and must be clearly mentioned in the case report form.

You may not qualify if:

• Persons not covered by the national Health Insurance Agency
• Psychotic or bipolar disorders
• Severe personality disorders
• cardiovascular disease, proven inflammatory disease and cancer
• persons unable to give their consent personally,
• persons in emergency situations,
• pregnant women,
• breast-feeding women

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

CHU de Dijon

Dijon, 21079, France

Location

Related Publications (1)

• Teyssier JR, Chauvet-Gelinier JC, Ragot S, Bonin B. Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores. PLoS One. 2012;7(11):e49677. doi: 10.1371/journal.pone.0049677. Epub 2012 Nov 21.

  PMID: 23185405 RESULT

MeSH Terms

Conditions

Depressive Disorder

Condition Hierarchy (Ancestors)

Mood Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 17, 2013
• First Posted: July 19, 2013
• Study Start: April 1, 2010
• Primary Completion: November 1, 2012
• Study Completion: November 1, 2012
• Last Updated: February 9, 2026

Record last verified: 2026-02

Locations

FR (1)