Malaria Survey in the Tak Province Refugee Camps

NCT01902797 | Completed

• 1 other identifier: SMRU 1303
• Study Type: interventional
• Target: 908
• Locations: 1 country
• Sites: 1

Brief Summary

According to the World Malaria Report, there were significant decreases in the number of P.falciparum (PF) malaria cases worldwide in the past decade. On the Thai-Myanmar border where transmission is low and seasonal and where incidence of Multi-drugs resistant P.falciparum parasites is the highest, the same trend has been observed with a clear decline in malaria episodes and the ratio of P. falciparum/P. vivax (PF/PV. Economic development, unprecedented financial support, renewed efforts in vector control, a wider use of rapid diagnosic tests (RDTs) for malaria and the deployment of artemisinin based combination treatments (ACT) are the main contributing factors to those successes against malaria. However the emergence in Cambodia and on the Thai-Myanmar border of P.falciparum isolates that exhibit resistance to artesunate is threatening those gains . This is characterized by a slow parasite clearance rate observed in patients treated with artesunate. At the same time, recent SMRU surveys along the Thai-Burmese border using a new cutting-edge technology i.e. highly sensitive quantitative Real Time PCR (RT-PCR) able to detect very low parasitaemia (10 parasites per ml), found up to a 3-5 fold increase in the prevalence of malaria compared to what is found with the usual diagnostic tools such as microscopy, RDT or even conventional PCR. It seems that a large number of asymptomatic carriers with very low parasites counts (a large potential malaria reservoir) go undetected. If confirmed, this might pose the greatest obstacle for malaria elimination in the region and containment of artemisinin resistance. The purpose of the survey is to further study and understand the epidemiology of malaria in the refugee camp population using cutting-edge technology (RT-PCR) .

Conditions

Malaria

Keywords

Refugee camps; Household residence; Treated bednets; PCR

Outcome Measures

Primary Outcomes (1)

• Malaria prevalence

  Comparison of malaria prevalence by conventional microscopy and RT-PCR to determine the malaria epidemiology in the population

  1 day

Secondary Outcomes (4)

• Determine the percentage of households with at least one long lasting insecticide treated nets (LLIN) or insecticide treated nets (ITNs

  1 day

• Determine the percentage of refugees sleeping under an ITN/LLIN previous night

  1 day

• Determine the percentage of refugees who can recall at least 1 key messages on malaria control and containment/elimination

  1 day

• Determine percentage of refugees who stay overnight outside the camp

  1 day

Study Arms (1)

Household

EXPERIMENTAL

In each camp, the camp residences are divided into different sections (as clusters for sampling) by camp registration. In the first stage, sections are selected using Population-proportion-to size (PPS) method. In the second stage, households are randomly selected from the household list in each section provided by NGO and local committee. When a household is not responding, a nearest household on the north will be used as replacement. All family members and overnight guests aged above 5 years in the selected household will be invited for venous blood sample (2 ml); for children aged 1-5 years old, the blood sample (100 microL) will be obtained by finger prick; children younger than 1 year old are excluded. The head of household will be invited for a short questionnaire.

Other: Questionnaire

Interventions

Questionnaire OTHER

Participants will be invited to complete questionnaires and those who are over 5 year of age will be asked to give blood samples.

Household

Eligibility Criteria

• Age: 12 Months+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Head of household and all family members
• Overnight guests
• Age \> 12 months
• Willing to participate in the study and sign informed consent

You may not qualify if:

• All children \< 1 year
• Anyone reported history of abnormal blood coagulation
• Anyone who does not consent to participate in the survey

Sponsors & Collaborators

• University of Oxford: lead

Study Sites (1)

Refugee Camps

Mae Sot, Changwat Tak, 63110, Thailand

Location

MeSH Terms

Conditions

Malaria

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Stephane Proux, PhD

  Shoklo Malaria Research Unit

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 10, 2013
• First Posted: July 18, 2013
• Study Start: July 1, 2013
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2013
• Last Updated: April 28, 2016

Record last verified: 2016-04

Locations

TH (1)