NCT01895426

Brief Summary

The purpose of this study is to collect clinical and radiological mid-term (2 years) data on the ArcadiusXP L® lumbar stand-alone cage in a post-market clinical follow-up study (PMCF) limited to 32 patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
32

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Apr 2013

Longer than P75 for all trials

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2013

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

July 5, 2013

Completed
5 days until next milestone

First Posted

Study publicly available on registry

July 10, 2013

Completed
3.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2017

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2017

Completed
Last Updated

March 22, 2017

Status Verified

March 1, 2017

Enrollment Period

3.8 years

First QC Date

July 5, 2013

Last Update Submit

March 21, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • ODI (2y) - ODI(preop)

    Difference between Oswestry Disability Index (ODI) at 2 years and preoperative ODI

    2 years

Secondary Outcomes (7)

  • Fusion/arthrodesis status, and further radiological documentation of operated and adjacent levels

    2 years

  • Overall success

    2 years

  • Overall success

    2 years

  • Pain (back and leg)

    2 years

  • Adverse events

    2 years

  • +2 more secondary outcomes

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

adult patients

You may qualify if:

  • all indications as given by the instructions for use
  • Patients with persisting lumbosacral and pseudo-radicular pain scheduled for monosegmental lumbar interbody fusion from L4 to S1
  • Age 18 - 60
  • at least 6 months of unsuccessful treatment including conservative measures
  • Non-sequestrated and subligamentous prolapse

You may not qualify if:

  • all contraindications, which are listed in the instructions for use.
  • existing pregnancy, planned or occurring during study period
  • patients with a higher degree of segmental degeneration in other than the segment to be operated
  • body- mass-index (BMI) \> 30
  • Systemic or local infection
  • Increased risk of osteoporosis according to assessment by the SCORE evaluation
  • Bone metabolism disorders
  • Chemotherapy or radiotherapy (ongoing or planned)
  • Participation in another clinical trial
  • Scheduled for spinal litigation
  • Other serious conditions that hinder the participation in the study
  • Nanogel® filling of the cage, prior to implantation was not done

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Sana Kliniken Sommerfeld

Kremmen, 16766, Germany

Location

St. Bonifatius Hospital Lingen

Lingen, 49808, Germany

Location

MeSH Terms

Conditions

Intervertebral Disc Degeneration

Condition Hierarchy (Ancestors)

Spinal DiseasesBone DiseasesMusculoskeletal Diseases

Study Officials

  • Peter Douglas Klassen, MD (PY)

    St. Bonifatius Hospital Lingen

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 5, 2013

First Posted

July 10, 2013

Study Start

April 1, 2013

Primary Completion

January 1, 2017

Study Completion

February 1, 2017

Last Updated

March 22, 2017

Record last verified: 2017-03

Locations