NCT01882452|CompletedDMC
A Randomised Controlled Clinical Trial of Memory Specificity Training (MEST) for Depression
MEST
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MEST
Sponsor study identifier
interventional
60
1 country
1
Study Start
July 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2016
Actual (reported)Study Completion
October 2016
Actual (reported)Depression involves the tendency to recall overgeneral personal memories, a phenomenon which has been linked to numerous adverse psychological outcomes. The purpose of this study is to investigate whether a group-based Memory Specificity Training (MEST) programme improves outcomes in depression, and how this compares to an education and support control group. The primary aim is to examine whether MEST, which involves repeated practice retrieving specific autobiographical memories reduces depressive symptoms immediately post-treatment, and whether this is maintained 3 months after treatment. The secondary objective of this trial is to examine the role of hypothesised cognitive processes (ie., rumination, executive control, cognitive avoidance) which may underlie improvements in depression and memory.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2016
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 18, 2013
Actual (reported)June 20, 2013
Actual (reported)July 2013
Date type not reportedThis date has not been verified as actual or estimated.
August 2016
Actual (reported)October 2016
Actual (reported)Change from baseline in depressive symptoms on the Beck Depression Inventory II (BDI-II)
Symptom severity score
Change from baseline to 3 months post-treatment
Change in depressive status according to the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders - IV (SCID-IV)
Change from baseline at end of treatment (approximately 6 weeks) and 3 months post-treatment, and 6-months post-treatment (6-month follow-up for MEST group only)
Change from baseline in autobiographical memory specificity on Autobiographical Memory Test (AMT)
Change from baseline at end of treatment (approximately 6 weeks) and 3 months post-treatment
Change from baseline in depressive symptoms as measured on the BDI-II
Change from baseline to post-treatment (approximately 6-weeks)
Depression free days following treatment according to the Longitudinal Follow-up Evaluation on the SCID-IV
Post-treatment and 3-month and 6-month follow-up
Change from baseline on the Beck Anxiety Inventory (BAI)
Change from baseline at end of treatment (approximately 6 weeks) and 3 months post-treatment
Change from baseline on the Beck Hopelessness Scale (BHS)
Change from baseline at end of treatment (approximately 6 weeks) and 3 months post-treatment
Change from baseline on the Cognitive Avoidance Questionnaire (CAQ)
Change from baseline at end of treatment (approximately 6 weeks) and 3 months post-treatment
Five weekly one-hour sessions of memory specificity training administered in groups of 5-8 participants.
Five weekly one-hour sessions of an education-and-discussion supportive intervention, administered in groups of 5-8 participants.
This intervention is a manualised, structured treatment delivered over 5 x 60 minute sessions to groups of 5-8 individuals. This treatment involves repeated practice of retrieving specific autobiographical memories in response to positive, negative and neutral cue words. There is a single psychoeducation component in the first session about memory difficulties common in depression which provides the rationale for this treatment. The training is supplemented by weekly homework practice.
Aliza Werner-Seidler
Sydney, 2022, Australia
Werner-Seidler A, Hitchcock C, Bevan A, McKinnon A, Gillard J, Dahm T, Chadwick I, Panesar I, Breakwell L, Mueller V, Rodrigues E, Rees C, Gormley S, Schweizer S, Watson P, Raes F, Jobson L, Dalgleish T. A cluster randomized controlled platform trial comparing group MEmory specificity training (MEST) to group psychoeducation and supportive counselling (PSC) in the treatment of recurrent depression. Behav Res Ther. 2018 Jun;105:1-9. doi: 10.1016/j.brat.2018.03.004. Epub 2018 Mar 15.
Dalgleish T, Bevan A, McKinnon A, Breakwell L, Mueller V, Chadwick I, Schweizer S, Hitchcock C, Watson P, Raes F, Jobson L, Werner-Seidler A. A comparison of MEmory Specificity Training (MEST) to education and support (ES) in the treatment of recurrent depression: study protocol for a cluster randomised controlled trial. Trials. 2014 Jul 22;15:293. doi: 10.1186/1745-6215-15-293.
Tim Dalgleish, PhD
Medical Research Council
60 participants (actual enrollment reported by the registry).
First Submitted
June 18, 2013
First Posted
June 20, 2013
Study Start
July 2013
Date type not reportedThis date has not been verified as actual or estimated.
Type 1 Diabetes and Depression: Role of Brain Glutamate
The education-and-support comparison condition is matched with the experimental arm for length and format (ie., 5 x 60 minute weekly sessions in groups of 5-8 individuals). Groups receive a single psychoeducation component where information about depression is provided. This is followed by non-directive support where participants are encouraged to raise different kinds of events that occur each week for discussion in the group. The sessions are supplemented by a homework diary where participants will be invited to note down an event that occurs each day, which may be positive, negative, or benign and non-emotional in nature. This material will provide the basis for discussion in the weekly group meetings.
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Primary Completion
August 2016
Actual (reported)Study Completion
October 2016
Actual (reported)Last Updated
March 22, 2018
Record last verified: 2018-03
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Source: ClinicalTrials.gov.
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