The Effect of Obesity on Oral Peri-implant Health - A Cross-Sectional Study

NCT01878071 | Completed

• 1 other identifier: UIOB01
• Study Type: observational
• Target: 73
• Locations: 1 country
• Sites: 1

Brief Summary

In recent years, greater emphasis has been placed on the link between oral and systemic health. Obesity, a growing medical problem worldwide, has been associated with multiple chronic inflammatory diseases such as diabetes mellitus and cardiovascular disease. With respect to the effect of obesity on periodontal health, it has been shown that obese subjects exhibit higher inflammation around natural teeth and are at increased risk of tooth loss than individuals with normal weight. Peri-implantitis, an inflammatory condition of bacterial origin that occurs around oral implants and resembles periodontal disease, has become a serious concern for the dental profession given its increasing prevalence and challenging treatment. There is also strong evidence that individuals with a history of periodontitis are also at risk for peri-implantitis. However, knowledge about the pathogenesis and treatment of peri-implantitis is scarce. Hence, it is extremely important to understand the implications of excessive body fat on peri-implant health. Based on the current understanding on the effect of obesity on systemic and local inflammation around natural teeth, the investigators hypothesize that obesity will have a significant impact on peri-implant health by inducing an increased inflammatory response as measured by clinical as well as molecular markers of inflammation.

Conditions

Obesity; Peri-implant Inflammation; Peri-implantitis

Outcome Measures

Primary Outcomes (1)

• Degree of peri-implant inflammation

  Single time point - during their single visit (day one)

Study Arms (1)

Single group cross sectional

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects in maintenance dental care with at least one rough surface titanium oral implant in function

You may qualify if:

• Adults (18 years or older)
• Currently non-smokers
• Subjects in maintenance care with adequate dental plaque control (\<20% plaque index according to O'Leary et al. 1972)
• Subjects with at least one rough surface titanium oral implant in function for at least 6 months.

You may not qualify if:

• Edentulous subjects or subjects presenting with blade-type implants and/or implants with smooth surface.
• Pregnant or nursing women
• Subjects who have taken medications that are known to alter the oral inflammatory status, such as antibiotics and anti-inflammatory agents, for 3 months prior to the study.
• Subjects with a history of aggressive periodontitis (As defined by the American Academy of Periodontology).

Sponsors & Collaborators

• University of Iowa: lead
• Osseointegration Foundation: collaborator
• University of Iowa Institute of Clinical and Translational Science: collaborator

Study Sites (1)

Craniofacial Clinical Research Center at the University of Iowa

Iowa City, Iowa, 52242, United States

Location

Related Publications (2)

• Koldsland OC, Scheie AA, Aass AM. Prevalence of peri-implantitis related to severity of the disease with different degrees of bone loss. J Periodontol. 2010 Feb;81(2):231-8. doi: 10.1902/jop.2009.090269.

  PMID: 20151801 BACKGROUND

• Al-Zahrani MS, Bissada NF, Borawskit EA. Obesity and periodontal disease in young, middle-aged, and older adults. J Periodontol. 2003 May;74(5):610-5. doi: 10.1902/jop.2003.74.5.610.

  PMID: 12816292 BACKGROUND

MeSH Terms

Conditions

Obesity; Peri-Implantitis

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 22, 2013
• First Posted: June 14, 2013
• Study Start: June 1, 2012
• Primary Completion: June 1, 2013
• Last Updated: May 20, 2014

Record last verified: 2014-05

Locations

US (1)