The Genetic Characterization of Dementia

NCT01867359 | Completed

• 2 other identifiers: 99990332603-AG-N326
• Study Type: observational
• Target: 87
• Locations: 1 country
• Sites: 1

Brief Summary

Background: \- Researchers are interested in learning more about dementia and its causes. They want to look at the genetic basis of dementia. Identifying genetic aspects of dementia may help provide better tests and treatments for it. It may also show rare gene variants that can cause or alter a person's risks for developing dementia. This study will look at people who have dementia, their family members, and healthy volunteers. Objectives: \- To study genetic influences on dementia. Eligibility:

• Individuals who have been diagnosed with dementia.
• Family members of individuals who have been diagnosed with dementia.
• Healthy volunteers at least 18 years of age. Design:
• Participants will be interviewed and answer questions about their medical history. They will also provide general information on the relatives' medical histories.
• Participants will provide a blood sample for genetic testing.
• Participants will remain on the study for up to 10 years. They will have regular visits to monitor their brain health and function.
• Treatment will not be provided as part of this study.

Conditions

Dementia

Keywords

Alzheimer Disease; Molecular; Molecular Genetics; DNA

Outcome Measures

Primary Outcomes (1)

• Genetic cause of disease identified

  Once every 12-24 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Previous diagnosis of Dementia by neurologist, other medical care provider, or researcher accompanied by sufficient clinical and/or laboratory evidence
• Clinical confirmation of Dementia by the investigator and his associates either by exam and/or review of medical records
• Family member of diagnosed dementia patient
• Healthy controls

You may not qualify if:

• Individuals with any movement disorder secondary to a specific environmental exposure, birth injury, metabolic disorder, or brain infection such as encephalitis.

Sponsors & Collaborators

• National Institute on Aging (NIA): lead

Study Sites (1)

National Institute of Aging, Clinical Research Unit

Baltimore, Maryland, 21224, United States

Location

MeSH Terms

Conditions

Dementia; Alzheimer Disease

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Tauopathies; Neurodegenerative Diseases

Study Officials

• Andrew Singleton, Ph.D.

  National Institute on Aging (NIA)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 29, 2013
• First Posted: June 4, 2013
• Study Start: March 14, 2003
• Primary Completion: September 20, 2016
• Study Completion: September 20, 2016
• Last Updated: April 5, 2018

Record last verified: 2016-09-20

Locations

US (1)