Epidemiological Study of Colorectal Cancer in WuHan

NCT01863303 | Unknown DMC

• 1 other identifier: R201206DCAPC
• Study Type: observational
• Target: 1
• Locations: 0 countries
• Sites: N/A

Brief Summary

The incidence risk of colorectal cancer （CRC） is increasing at 4.2% year by year in China. Most effective way to reduce the death rate of CRC patients is to diagnose in quite an early stage. QiaoKou District is a chemical industry Zone of Wuhan with a long history, which has few data of CRC epidemiology. The investigators design the primary CRC screening for this district by healthy questionnaire, Fecal Occult Blood Test(FOBT) and colonoscopy. HanYang Areo has been chosen as Control for its non-industry environment.The crowd would be screen biennially. The high risk group would be intervened, such as resection of polyps or other specific treatment. A follow-up registration database has been built for analysis the relationship between incidence or death rate to high risk factors, such as age, life environment, lifestyles, base diseases and family history of cancer. This study will provide some epidemiology dates of CRC to the local Government, and assist the governor to built a more effective screening system of CRC.

Conditions

Diarrhea; Constipation; Melena; Neoplasm; Colonic Neoplasms; Pain

Keywords

colorectal cancer; epidemiology; industry; genetic

Outcome Measures

Primary Outcomes (1)

• incidence of CRC

  June 2022 (up to 10 years)

Eligibility Criteria

• Age: 40 Years - 74 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Coulp of this study from a chemical industry Zone of Wuhan with a long history,seriously polluted environment， which has few data of CRC epidemiology. HanYang Areo has been choosen as Control for its non-industry environment

You may qualify if:

• Aged 40-74
• Resident of Qiaokou Areo，and at least ten years living history in this district
• Willing and able to provide written informed consent and authorization
• Willing to a personal interview and have some special tests

You may not qualify if:

• Under 43 or older than 74 years of age
• History of colorectal cancer
• Mental disorders

Sponsors & Collaborators

• Wuhan Pu-Ai Hospital: lead
• Wuhan University: collaborator
• Hubei Cancer Hospital: collaborator
• Huazhong University of Science and Technology: collaborator
• Wuhan Iron and Steel Workers' Hospital: collaborator

Biospecimen

Retention: SAMPLES WITH DNA

Blood sample or neoplasm from high risk group

MeSH Terms

Conditions

Diarrhea; Constipation; Melena; Neoplasms; Colonic Neoplasms; Pain; Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Gastrointestinal Hemorrhage; Gastrointestinal Diseases; Digestive System Diseases; Hemorrhage; Pathologic Processes; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Colonic Diseases; Intestinal Diseases; Neurologic Manifestations; Rectal Diseases

Study Officials

• Yan Li, doctor

  Zhongnan hospital of Wuhan university, China

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 22, 2013
• First Posted: May 27, 2013
• Study Start: June 1, 2012
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2018
• Last Updated: May 27, 2013

Record last verified: 2013-05