Korean Registry of Target Organ Damages in Hypertension

NCT01861080 | Unknown DMC

• 1 other identifier: 2012-005
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to know prevalence of clinical or subclinical target organ damages in Korea hypertensives by constructing nationwide hypertension registry. We will register 5000 consecutive patients with incident hypertension at 20 major university hospitals in South Korea. We will investigate clinical/subclinical target organ damages, renin/aldosterone level and cardiovascular events in each patient.

Conditions

Hypertension

Keywords

target organ damage; incident hypertension; cohort

Outcome Measures

Primary Outcomes (8)

• left ventricular hypertrophy

  left ventricular hypertrophy on electrocardiogram or echocardiography Sokolow-Lyon \> 38 mm; left ventricular mass index male \>= 125 g/m2, female \>=110 g/m2)

  at enrollment

• Intima media thickness of carotid artery

  increased intima media thickness of carotid artery (\> 0.9 mm) or presence of plaque

  at enrollment

• pulse wave velocity

  increased pulse wave velocity (\> 12 m/s)

  at enrollment

• kidney function

  low estimated glomerular filtration rate (\< 60 ml/min/1.73 m2) or creatinine clearance (\< 60 ml/min)

  at enrollment

• cerebrovascular accident

  ischemic stroke, cerebral hemorrhage, or transient ischemic attack confirmed by a neurologist

  at enrollment

• renal disease

  serum creatinine male \> 1.5 mg/dl, female \> 1.4 mg/dl; proteinuria \> 300 mg/24hr

  at enrollment

• peripheral artery disease

  ankle to brachial blood pressure ratio \< 0.9

  at enrollment

• retinopathy

  retinal hemorrhage or exudate, papilledema confirmed by an ophthalmologist

  at enrollment

Secondary Outcomes (5)

• Hypertension

  at enrollment

• Dyslipidemia

  at enrollment

• abnormal fasting plasma glucose

  at enrollment

• abdominal obesity

  at enrollment

• diabetes mellitus

  at enrollment

Other Outcomes (1)

• major cardiovascular events

  after follow-up period of 36 months

Study Arms (1)

incident hypertensives

Inclusion Criteria: * age≧30years * primary incident hypertension * signed informed consent

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Korean patients with incident hypertensive, who visited university hospital

You may qualify if:

• age≧30years
• primary incident hypertension
• singed informed consent

You may not qualify if:

• participated in other clinical trials

Sponsors & Collaborators

• Dongtan Sacred Heart Hospital: lead

Study Sites (1)

Hallym University Dongtan Sacred Heart Hospital,

Hwaseong, Gyeonggido, 445-170, South Korea

Location

Related Publications (1)

• Choi SW, Han SW, Ok JS, Yoo BS, Shin MS, Park SH, Ryu KH. A multicenter cohort study of primary hypertension in Korea: study design and interim analysis of the Korean registry of target organ damage in hypertension (KorHR). Clin Hypertens. 2017 Aug 2;23:16. doi: 10.1186/s40885-017-0072-2. eCollection 2017.

  PMID: 28794898 DERIVED

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Kyu-Hyung Ryu, MD, PhD

  Dongtan Sacred Heart Hospital, Hallym University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 36 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Kyu-Hyung Ryu, M.D., Professor

Study Record Dates

• First Submitted: May 16, 2013
• First Posted: May 23, 2013
• Study Start: May 1, 2013
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: February 8, 2019

Record last verified: 2019-02

Locations

KR (1)