Project 4: Acute Effects of Alcohol on Learning and Habitization in Healthy Young Adults

NCT01858818 | Completed

• 1 other identifier: ZI 1119/4-1
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

This project aims to investigate how dysfunctional learning and habitization are affected by acute alcohol exposure, and whether individual differences in such alcohol effects can predict later development of Alcohol Use Disorders (AUDs). Eighty 18-year-old healthy male subjects are tested on two days in a within-subjects design with blinded administration of alcohol vs. placebo and different behavioral and learning tasks. The investigators investigate how alcohol influences the performance during these tasks, whether alcohol effects differ between high- and low-risk subjects, and whether task performance under alcohol predicts future AUDs.

Conditions

Alcoholism

Keywords

CAIS Computer Assisted Infusion System; real life drinking behavior; family history of alcoholism; conditioning; instrumental learning; habitization

Outcome Measures

Primary Outcomes (1)

• individual learning parameters

  estimated by computational modeling of behavioral performance in learning/conditioning tasks the investigators test effects of individual parameters on actual risk factors of AUDs and future AUDs

  2 days at age 18

Secondary Outcomes (1)

• individual approach/avoidance reaction time differences

  2 days at age 18

Other Outcomes (1)

• lexical decision task performance

  2 days at age 18

Study Arms (1)

healthy 18 year old males

Eligibility Criteria

• Age: 18 Years - 18 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

random sampling of representative sample of 18 year old men in the area of Dresden

You may qualify if:

• men at age 18
• signed informed consent
• social drinking in the three months before participation participation, defined by at least two drinking days in any four weeks-interval
• ability to provide AUD information about biological parents and grandparents

You may not qualify if:

• lifetime history of Diagnostic Statistical Manual-IV bipolar or psychotic disorder
• current diagnosis of one of the following disorders: major depressive disorder, generalized anxiety disorder, PTSD, borderline personality disorder, or obsessive-compulsive disorder
• prior treatment for any axis-I or axis-II disorder except for specific disorders of childhood and adolescence (i.e., oppositional defiant disorder, conduct disorder, ADHD)
• history of substance dependence other than nicotine dependence
• current substance use other than nicotine and alcohol as evinced by positive urine screen
• history of severe head trauma or other severe central neurological disorder (e.g. multiple sclerosis)
• alcohol intake in the last 24 hours before test days
• use of medications or drugs known to interact with the central nervous system within the last 10 days or at least four half-lives post last intake

Sponsors & Collaborators

• Technische Universität Dresden: lead

Study Sites (1)

University Hospital Carl Gustav Carus

Dresden, Saxony, 01307, Germany

Location

Related Publications (1)

• Junger E, Javadi AH, Wiers CE, Sommer C, Garbusow M, Bernhardt N, Kuitunen-Paul S, Smolka MN, Zimmermann US. Acute alcohol effects on explicit and implicit motivation to drink alcohol in socially drinking adolescents. J Psychopharmacol. 2017 Jul;31(7):893-905. doi: 10.1177/0269881117691454. Epub 2017 Feb 21.

  PMID: 28675116 DERIVED

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Ulrich Zimmermann, PD Dr.

  University Hospital Carl Gustav Carus at TU Dresden

  PRINCIPAL INVESTIGATOR

• Michael Smolka, Prof. Dr.

  Section of Systems Neuroscience at TU Dresden

  PRINCIPAL INVESTIGATOR

• Hans-Ulrich Wittchen, Prof. Dr.

  TU Dresden

  STUDY CHAIR

• Andreas Heinz, Prof. Dr.

  Charite University, Berlin, Germany

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 17, 2013
• First Posted: May 21, 2013
• Study Start: June 1, 2013
• Primary Completion: October 1, 2014
• Study Completion: October 1, 2014
• Last Updated: February 12, 2015

Record last verified: 2015-02

Locations

DE (1)