Prospective Assessment of Adolescent Drinking Trajectories With Computer-Assisted Self-administration of Ethanol (CASE)
Collaboration on Alcohol Self Administration in Adolescents and Young Adults - Specific Aim 1: Assess the Initial Slope of Adolescent Drinking Trajectories, Beginning at the Age of Eighteen
2 other identifiers
observational
96
1 country
1
Brief Summary
The Computer-Assisted Self-administration of Ethanol (CASE)will be administered twice, at the ages 18 and 20, in a prospective study of 80 adolescents living in the Dresden area. The sample will be recruited for a differential family history of alcoholism (FHA) and gender, with inventories of alcohol use disorder (AUD) symptoms and personal recent drinking history (RDH) obtained prior to each CASE session.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jun 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 4, 2010
CompletedFirst Posted
Study publicly available on registry
February 5, 2010
CompletedStudy Start
First participant enrolled
June 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2015
CompletedJanuary 21, 2016
January 1, 2016
1.8 years
February 4, 2010
January 20, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Alcohol consumption
Alcohol consumption, as measured by a Timeline Followback Interview and experimental Self-Administration.
2 years
Secondary Outcomes (1)
Alcohol Use Disorders
2 years
Eligibility Criteria
Residents living within 15 km (9.5 miles) from downtown Dresden
You may qualify if:
- (a) male and female Caucasian volunteers aged 18 years/0 months to 19 years/11 months;
- (b) written informed consent by the subject;
- (c) habitual social drinking during the two months preceding participation, defined by at least one drinking day in any two weeks-interval;
- (d) at least one prior experience of alcohol intoxication
- (e) being able to abstain from tobacco use for four hours without developing nicotine withdrawal symptoms;
- (f) effective contraception in female participants;
- (g) consenting to abstain from any illegal substance use for 2 weeks prior to participation;
- (h) living within 15 km (9.5 miles) from downtown Dresden;
- (i) sufficient information concerning alcohol use in both parents and in at least four second-degree relatives
You may not qualify if:
- (a) prior medical treatment due to alcohol use;
- (b) current or prior history of any serious disease, including CNS, cardiovascular, respiratory, gastrointestinal, hepatic, renal, endocrine, alcohol or drug dependence, but not alcohol abuse;
- (c) current history of Axis-I psychiatric illness, including premenstrual dysphoric disorder;
- (d) current or prior history of alcohol-induced flushing reactions;
- (e) positive urine screen for cannabinoids, cocaine, amphetamines, opiates, or benzodiazepines;
- (f) light or non-drinkers: averaging less than 2 standard drinks per week in the preceding two months;
- (g) intention to become pregnant
- (h) pregnancy or positive urine pregnancy screening or breast-feeding;
- (i) any alcohol intake on the test day or the day before;
- (k) use of medications known to interact with alcohol within 2 weeks of the study;
- (l) positive hepatitis or HIV at screening, provided the subject consented to these tests
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Universitaetsklinikum Carl Gustav Carus at the Technische Universitaet Dresden
Dresden, Saxony, 01307, Germany
Related Publications (1)
Obst E, Bernhardt N, Gan G, Plawecki MH, O'Connor S, Smolka MN, Zimmermann US. Sensation seeking, impulsivity, and aggression moderate sex effects on adolescent laboratory binging. Psychol Addict Behav. 2021 Mar;35(2):208-214. doi: 10.1037/adb0000651. Epub 2020 Jun 25.
PMID: 32584051DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ulrich S Zimmermann, Dr.
Universitaetsklinikum Carl Gustav Carus at the Technische Universitaet Dresden
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 4, 2010
First Posted
February 5, 2010
Study Start
June 1, 2010
Primary Completion
March 1, 2012
Study Completion
December 1, 2015
Last Updated
January 21, 2016
Record last verified: 2016-01