A Prospective Observational Cohort to Study the Genetics of Obstructive Sleep Apnea and Associated Co-Morbidities

NCT01857427 | Active Not Recruiting DMC

• 1 other identifier: 2012H0214
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to build a well characterized cohort of patients that will be used to determine the genetic variants associated with obstructive sleep apnea (OSA)and its co-morbidities.

Conditions

Obstructive Sleep Apnea

Outcome Measures

Primary Outcomes (1)

• Sleep Questionnaire

  Responses to sleep questionnaire

  upon enrollment

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult subjects 18 years of age and older who are scheduled for polysomnography (PSG), regardless of final diagnosis AND adult subjects who have already been diagnosed with OSA based on a prior PSG and are already on treatment. OSA diagnosis will be defined as an apnea/hypopnea index (AHI) \>or =5 episodes per hour.

You may qualify if:

• We will recruit subjects who are:
• years of age and older.
• Willing and able to give informed consent
• AND any of the following:
• PSG (polysomnogram)requested by a physician based on clinical grounds
• AHI (Apnea-hypopnea index) ≥ 5 episodes per hour based on a prior PSG.

You may not qualify if:

• Incapable of giving informed consent
• Under the age of 18

Sponsors & Collaborators

• Ulysses Magalang MD: lead

Study Sites (1)

Suite 2600, Martha Morehouse Medical Pavilion

Columbus, Ohio, 43221, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

blood or saliva sample

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Officials

• Ulysses Magalang, MD

  Ohio State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor of Internal Medicine

Study Record Dates

• First Submitted: May 10, 2013
• First Posted: May 20, 2013
• Study Start: August 1, 2012
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)