NCT01799265

Brief Summary

The purpose of this study is to determine whether the Transcend Auto is as effective in treating obstructive sleep apnea as another device that is already on the market.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
41

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2013

Shorter than P25 for not_applicable

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 19, 2013

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 26, 2013

Completed
1 day until next milestone

Study Start

First participant enrolled

February 27, 2013

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 10, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 10, 2013

Completed
11.6 years until next milestone

Results Posted

Study results publicly available

January 13, 2025

Completed
Last Updated

January 13, 2025

Status Verified

October 1, 2022

Enrollment Period

3 months

First QC Date

February 19, 2013

Results QC Date

December 6, 2021

Last Update Submit

January 8, 2025

Conditions

Keywords

obstructive sleep apneaOSAAutoPAPPAPsleep disordered breathingCPAPApnea hypopnea indexAHI

Outcome Measures

Primary Outcomes (1)

  • Mean Apnea Hypopnea Index (AHI) During Treatment

    Apnea hypopnea index (AHI) will be measured during treatment with each of the devices. AHI = (number of apneas + number of hypopneas) / total sleep time in hours. The minimum score is zero. The higher the score, the more severe the sleep apnea. For example, obstructive sleep apnea is defined as an AHI \>/= 15. AHI was measured by the devices and independently by a central laboratory.

    first and second night sleep study

Secondary Outcomes (2)

  • Unanticipated Adverse Device Effects

    first and second night sleep study

  • Mean Differences Between Polysomnography (PSG) and Device Measures of Apnea Index (AI) and Hypopnea Index (HI)

    first and second night sleep study

Study Arms (2)

Transcend followed by REMstar

ACTIVE COMPARATOR

The patient will receive treatment with Transcend during the first night sleep study, followed by treatment with the REMstar on the second night.

Device: Somnetics Transcend AutoDevice: Respironics REMstar Auto with C-Flex

REMstar followed by Transcend

ACTIVE COMPARATOR

The patient will receive treatment with REMstar during the first night sleep study followed by treatment with Transcend on the second night.

Device: Somnetics Transcend AutoDevice: Respironics REMstar Auto with C-Flex

Interventions

REMstar followed by TranscendTranscend followed by REMstar
REMstar followed by TranscendTranscend followed by REMstar

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adult 18 years of age or older
  • Diagnosis of obstructive sleep apnea
  • Presently using CPAP or APAP therapy

You may not qualify if:

  • Central or mixed apnea

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Northwind Lung Specialists and Sleep Center

Coon Rapids, Minnesota, 55433, United States

Location

Whitney Sleep Center

Plymouth, Minnesota, 55441, United States

Location

Sleep Therapy and Research Center

San Antonio, Texas, 78229, United States

Location

MeSH Terms

Conditions

Sleep Apnea, ObstructiveSleep Apnea Syndromes

Condition Hierarchy (Ancestors)

ApneaRespiration DisordersRespiratory Tract DiseasesSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System Diseases

Results Point of Contact

Title
Melinda Swanson
Organization
Bluebird Consulting

Study Officials

  • Eric Powell, PhD RPSGT

    Sleep Therapy and Research Center

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
LTE60
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 19, 2013

First Posted

February 26, 2013

Study Start

February 27, 2013

Primary Completion

June 10, 2013

Study Completion

June 10, 2013

Last Updated

January 13, 2025

Results First Posted

January 13, 2025

Record last verified: 2022-10

Locations