Bitter Taste and Weight Loss in Women

NCT01856660 | Completed

• 1 other identifier: AHA12060259
• Study Type: interventional
• Target: 107
• Locations: 1 country
• Sites: 1

Brief Summary

Individual food preferences are not considered in designing weight-loss therapies. This project will determine if short-term weight-loss is improved by matching participants with diets that reflect their genetically-determined food preferences.

Conditions

Obesity; Weight Loss

Keywords

Obesity; Weight Loss; Body Weight Change; Taste; Taste Phenotype; Lifestyle Intervention

Outcome Measures

Primary Outcomes (1)

• Weight Loss

  Change in weight (Kg)

  0, 3 months, and 6 months

Secondary Outcomes (1)

• Diet

  0, 3 months, and 6 months

Other Outcomes (2)

• Physical Activity

  0, 3 months, and 6 months

• Eating Attitudes

  0, 3 months, and 6 months

Study Arms (2)

Low-Fat Diet

EXPERIMENTAL

Participants are provided with a 6-month standard lifestyle intervention. They will follow an energy restricted, low-fat diet where the daily energy consumption target is 1,200- 1,500 kilocalories/d. The fat intake target is 28% or less of daily kilocalories. Gradual increase in physical activity until participants are active at least 40 min per day, 5 times/week.

Behavioral: Low-fat Diet

Low-Carbohydrate Diet

EXPERIMENTAL

Participants are provided with a 6-month standard lifestyle intervention. They will follow a low-carbohydrate diet where the daily carbohydrate target is 50g/d. There is no energy restriction. Gradual increase in physical activity until participants are active at least 40 min per day, 5 times/week.

Behavioral: Low-Carbohydrate Diet

Interventions

Low-Carbohydrate Diet BEHAVIORAL

Participants are provided with a 6-month standard lifestyle intervention where carbohydrate intake is limited to 50 g/day. There is no calorie restriction for participants following the Low-Carbohydrate diet. Gradual increase in physical activity across the trial to \> 40 min per day, 5 times/week.

Low-Carbohydrate Diet

Low-fat Diet BEHAVIORAL

Participants are provided with a 6-month standard lifestyle intervention. They will follow an energy restricted, low-fat diet where the daily energy consumption target is 1,200- 1,500 kilocalories/d. The fat intake target is 28% or less of daily kilocalories. Gradual increase in physical activity until participants are active at least 40 min per day, 5 times/week.

Low-Fat Diet

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body mass index (BMI) between 27 and 40 kg/m squared No weight loss for 3 months prior to the study Stable hypertension, dyslipemia or Type 2 diabetes - with permission from primary care provider Oral therapy to treat Type 2 diabetes - with permission from primary care provider.
• Able to walk 2 block without stopping

You may not qualify if:

• Pregnant, lactating or planning to become pregnant during the trial History of cardiovascular disease (infarct, angina, arrhythmia or stroke) Recent chemotherapy or radiation therapy Liver, renal or thyroid disease Concurrent or recent (last 6 months) participation in any other weight loss intervention Insulin injection Medications to control appetite or weight Major psychiatric illnesses

Sponsors & Collaborators

• Rutgers University: lead

Study Sites (1)

Rutgers University, Department of Food Science

New Brunswick, New Jersey, 08901, United States

Location

Related Publications (2)

• Burgess B, Raynor HA, Tepper BJ. PROP Nontaster Women Lose More Weight Following a Low-Carbohydrate Versus a Low-Fat Diet in a Randomized Controlled Trial. Obesity (Silver Spring). 2017 Oct;25(10):1682-1690. doi: 10.1002/oby.21951. Epub 2017 Aug 25.

  PMID: 28841772 DERIVED

• Burgess B, Rao SP, Tepper BJ. Changes in liking for sweet and fatty foods following weight loss in women are related to prop phenotype but not to diet. Obesity (Silver Spring). 2016 Sep;24(9):1867-73. doi: 10.1002/oby.21570. Epub 2016 Jul 19.

  PMID: 27430708 DERIVED

MeSH Terms

Conditions

Obesity; Weight Loss; Body Weight Changes

Interventions

Diet, Carbohydrate-Restricted; Diet, Fat-Restricted

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diet Therapy; Nutrition Therapy; Therapeutics; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Beverly J Tepper, PhD

  Rutgers University, Deptartment of Food Science

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD, Professor

Study Record Dates

• First Submitted: May 14, 2013
• First Posted: May 17, 2013
• Study Start: September 1, 2012
• Primary Completion: June 1, 2015
• Study Completion: August 1, 2016
• Last Updated: August 24, 2021

Record last verified: 2021-08

Locations

US (1)