Hippocampal Metabolism and Function in Patients With Type 1 Diabetes

NCT01852968 | Completed DMC

• 1 other identifier: 1301M26901
• Study Type: observational
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

The hippocampus is an area of brain which plays an essential role in learning and memory processing and is thought to be particularly vulnerable to effects of hypoglycemia (low blood glucose). The goal of this project is to examine hippocampal neurochemistry and metabolism and identify how diabetes and recurrent hypoglycemia alter the hippocampus.

Conditions

Hypoglycemia; Diabetes Mellitus

Keywords

hypoglycemia; hypoglycemia unawareness; type 1 diabetes, hippocampus; glucose transport; cognitive dysfunction

Outcome Measures

Primary Outcomes (1)

• alterations in hippocampal glucose transport kinetics

  Hippocampal glucose transport kinetics will be examined using magnetic resonance spectroscopy

  data will be acquired at the time of experiment.

Secondary Outcomes (2)

• hippocampal function

  data will be collected on day of experiment

• alterations in hippocampal neurochemistry

  data will be acquired at the time of experiment

Study Arms (2)

Patients with type 1 diabetes

Hippocampal neurochemistry and metabolism will examined in Patients with type 1 diabetes using magnetic resonance spectroscopy. Patients with type 1 diabetes will also undergo neurocognitive testing to assess hippocampal function

healthy controls

Hippocampal neurochemistry and metabolism will be examined in healthy controls using magnetic resonance spectroscopy. Healthy controls will also undergo neurocognitive testing to assess hippocampal function

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

University of Minnesota Endocrine Clinic, univeristy of Minnesota community and a registry of volunteers maintained by the investigators.

You may qualify if:

• diagnosis of type 1 diabetes, hemoglobin A1C \<9%. Alternatively, subject should be a healthy control.

Sponsors & Collaborators

• University of Minnesota: lead

Study Sites (1)

Clinical and Translational Science Institute and Center for Magnetic Resonance Research, University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

Related Publications (1)

• Bednarik P, Henry PG, Khowaja A, Rubin N, Kumar A, Deelchand D, Eberly LE, Seaquist E, Oz G, Moheet A. Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes. J Clin Endocrinol Metab. 2020 Feb 1;105(2):479-91. doi: 10.1210/clinem/dgz062.

  PMID: 31637440 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood smaple will be drawn measurement of blood glucose, HgbA1C, insulin and hormone levels

MeSH Terms

Conditions

Hypoglycemia; Diabetes Mellitus; Diabetes Mellitus, Type 1; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Autoimmune Diseases; Immune System Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Amir Moheet, MD

  University of Minnesota

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 12, 2013
• First Posted: May 14, 2013
• Study Start: May 1, 2013
• Primary Completion: October 31, 2017
• Study Completion: October 31, 2017
• Last Updated: December 15, 2021

Record last verified: 2021-12

Locations

US (1)