The Efficacy of Enteral Nutrition in Fill of the Treatment Blank Period of the Postoperative Maintain Remission Medication for Crohn's Disease (CD)

NCT01823042 | Unknown

• 1 other identifier: CDS-2
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Crohn's disease(CD) is a agnogenic disease which has a lifelong relapse tendency even after surgery treatment.So maintain remission medications were routinely given to patients after surgery.But maintain remission medications,as azathioprine,6-MP, ciclosporin,tripterygium glycosides, had a onset time.The therapeutic effect may appear 3 months\~6months after taken medicine.There is a treatment blank period between surgery and onset time of maintain remission medications.Enteral nutrition has been used in the induction remission and maintain remission for CD.May be it can fill the treatment blank period.

Conditions

Crohn's Disease

Keywords

Crohn's Disease; maintain remission; postoperative recurrence; surgery; living quality

Outcome Measures

Primary Outcomes (2)

• The change of patients'CDAI.

  at 0 week, the 4 weeks, the 8 weeks, the 12weeks

• patients' endoscopic score(Rutgeerts score).

  at the 12weeks

Secondary Outcomes (3)

• The change of haematological inflammation marker(CRP,ESR)

  at 0 week, the 4 weeks, the 8 weeks, the 12weeks

• The change of patients'IBDQ.

  at 2 week, the 6 weeks, the 12 weeks

• The change of blood routine examination and blood biochemistry.

  at 0 week,4 weeks,8 weeks,12 weeks

Study Arms (2)

enteral nutrition+azathioprine

EXPERIMENTAL

Patients is fasting and receive enteral nutrition and azathioprine treatment.

Drug: azathioprine+enteral nutrition

azathioprine

EXPERIMENTAL

Patients have regular diet and receive only azathioprine treatment.

Drug: Azathioprine

Interventions

azathioprine+enteral nutrition DRUG

enteral nutrition+azathioprine

Azathioprine DRUG

azathioprine

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects should have a definitive diagnosis of Crohn's disease, based on WHO criteria
• Subjects having curative resection/ileocolonic anastomosis，pathologically diagnosed as Crohn's disease
• Lesions located in ileum or ileocecal region
• Males and females ≥ 18 years old, including women who are not pregnant or lactating at the time of enrollment.
• Body weight between 40 and 100 kg, inclusive.
• Subjects should have a CDAI score \<150 at week 0
• Able to swallow tablets
• Are capable of providing written informed consent and obtained at the time of enrollment
• Willing to adhere to the study visit schedule and other protocol requirements.

You may not qualify if:

• Bacterial,viral or other microbial infection(including HIV)
• any of the following medications taken within 12 weeks before surgery: cyclosporine, tacrolimus, sirolimus, mycophenolate mofetil, or other investigational drugs
• any of ongoing therapy for Crohn's disease with: 5-ASA compounds, steroids, immune modifiers, systemic antibiotics, and tube feeding
• Needing orally administered corticosteroids for the treatment of other diseases. Inhaled or dermatologic preparations are acceptable.
• Previous or current use of infliximab.
• current use of prescription doses or chronic/frequent use of NSAIDs
• Treatment with narcotic pain medications. (Anti-diarrheal agents such as loperamide and diphenoxylate are permitted, providing that the dose is not increased during the study period.)
• History of pancreatitis, except for subjects with a known but removed cause(such as gallstone pancreatitis)
• WBC \<3.0 x 109/L, hemoglobin \<80 g/L, Platelets\<50,000/mm3 at the time of enrollment (or within the previous 6 months, if known)
• History of abnormal liver function tests, including AST or ALT \>1.5 times upper limit of normal, alkaline phosphatase \>2 times upper limit of normal, total bilirubin \>2.5 mg/dL at screening (or within the previous 6 months, if known)
• With short bowel syndrome (defined as requiring oral or parenteral supplemental or total nutrition to maintain stable body weight, or more than 100 cm of small bowel resected)
• History of malignancy
• Women who are pregnant or lactating at the time of enrollment, or who intend to be during the study period.
• Participation in other clinical trial within the past 6 months

Sponsors & Collaborators

• Jinling Hospital, China: lead

Study Sites (1)

General Surgery Institute,Jinling Hospital

Nanjing, Jiangsu, 210000, China

RECRUITING

MeSH Terms

Conditions

Crohn Disease

Interventions

Azathioprine

Condition Hierarchy (Ancestors)

Inflammatory Bowel Diseases; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Intestinal Diseases

Intervention Hierarchy (Ancestors)

Thionucleosides; Sulfur Compounds; Organic Chemicals; Mercaptopurine; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Nucleosides; Nucleic Acids, Nucleotides, and Nucleosides

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: vice director of General surgery institute

Study Record Dates

• First Submitted: March 25, 2013
• First Posted: April 4, 2013
• Study Start: October 1, 2012
• Primary Completion: July 1, 2013
• Study Completion: July 1, 2013
• Last Updated: April 4, 2013

Record last verified: 2013-03

Locations

CN (1)