Manipulation of Dietary Protein and the Anabolic Response
PRO-ADAPT
The Manipulation of Dietary Protein Intake on the Anabolic Response in Healthy Young Men
1 other identifier
interventional
28
0 countries
N/A
Brief Summary
In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2013
Longer than P75 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 18, 2013
CompletedFirst Posted
Study publicly available on registry
March 29, 2013
CompletedStudy Start
First participant enrolled
April 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2017
CompletedMarch 22, 2017
May 1, 2015
1.9 years
March 18, 2013
March 21, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Muscle protein fractional synthetic rate following protein ingestion
The ability of the muscle to synthesise new proteins will be assessed over a 3 h period following protein ingestion and will be compared between groups. This only occurs on one occasion.
3 hours
Study Arms (2)
High protein intake
EXPERIMENTALHigh protein intake: large bolus of protein in teh diet the day before testing
No protein intake
PLACEBO COMPARATORNo protein in the diet the day before testing
Interventions
Eligibility Criteria
You may qualify if:
- Males
- Aged between 18-35 years
- Healthy, recreationally active
- BMI \< 30 kg/m2
You may not qualify if:
- Smoking
- Allergies to milk proteins (whey or casein)
- Vegetarians
- Diagnosed GI tract diseases
- Female
- Arthritic conditions
- A history of neuromuscular problems
- Previous participation in amino acid tracer studies
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Gorissen SHM, Trommelen J, Kouw IWK, Holwerda AM, Pennings B, Groen BBL, Wall BT, Churchward-Venne TA, Horstman AMH, Koopman R, Burd NA, Fuchs CJ, Dirks ML, Res PT, Senden JMG, Steijns JMJM, de Groot LCPGM, Verdijk LB, van Loon LJC. Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. J Nutr. 2020 Aug 1;150(8):2041-2050. doi: 10.1093/jn/nxaa024.
PMID: 32069356DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Luc JC van Loon, PhD
Maastricht University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 18, 2013
First Posted
March 29, 2013
Study Start
April 1, 2013
Primary Completion
March 1, 2015
Study Completion
February 1, 2017
Last Updated
March 22, 2017
Record last verified: 2015-05