Function and Modulation of Fibulin-1 Assembly in Nucleus of Corneal Fibroblasts
2 other identifiers
observational
5
0 countries
N/A
Brief Summary
The purpose of this study is to investigate the role of nuclear Fibulin-1 (FBLN1) in Human Corneal Fibroblasts under treatment of mitomycin C (MMC).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Aug 2012
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2012
CompletedFirst Submitted
Initial submission to the registry
September 13, 2012
CompletedFirst Posted
Study publicly available on registry
March 11, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedAugust 13, 2015
August 1, 2015
11 months
September 13, 2012
August 10, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Modification of nuclear Fibulin-1 accumulation in suppressing gene expression
3 days post mitomycin C treatment
Interventions
Eligibility Criteria
The original cell sources were collected from the donors with more than 20 years old following penetrating keratoplasty. After successfully amplified from the residual corneal rim following penetrating keratoplasty in the previous projects, human corneal fibroblasts (HCFs) were reserved in liquid nitrogen tank and were thawed for this study under in vitro cultivation and application.
You may qualify if:
- The frozen storage cells in liquid nitrogen were amplified from the residual corneal rim of the donors with more than 20 years old following penetrating keratoplasty.
You may not qualify if:
- The donors were younger than 20 years old.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Tsan-Chi Chen, PhD
Far Eastern Memorial Hospital
Study Design
- Study Type
- observational
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Department of Ophthalmology
Study Record Dates
First Submitted
September 13, 2012
First Posted
March 11, 2013
Study Start
August 1, 2012
Primary Completion
July 1, 2013
Study Completion
August 1, 2015
Last Updated
August 13, 2015
Record last verified: 2015-08