Brain Response to Treatment for Pediatric PTSD

NCT01806701 | Completed DMC

• 2 other identifiers: MH097769K01MH097769
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine how brain activation changes as a result of behavioral treatment for posttraumatic stress disorder (PTSD) in adolescents. The investigators will conduct functional magnetic resonance imaging (fMRI) scans before and after the widely-used trauma-focused cognitive behavioral therapy to better understand how the brain recovers from illness. This study will provide much needed information about brain abnormalities in abused youth, and could lead to improvements in behavioral treatments for patients who do not respond to current treatments.

Conditions

Emotions; Memory Deficits; Post-traumatic Syndrome

Keywords

fMRI; neuroimaging; PTSD; adolescent; trauma; brain

Outcome Measures

Primary Outcomes (1)

• functional magnetic resonance imaging (brain activation)

  We will use functional magnetic resonance imaging to measure changes in brain activation after 4 months of psychotherapy

  change in brain activation after 4 months of treatment (baseline and 4 months)

Study Arms (1)

Psychotherapy

EXPERIMENTAL

Trauma-focused Cognitive Behavioral Therapy

Behavioral: Trauma-focused cognitive behavioral therapy

Interventions

Trauma-focused cognitive behavioral therapy BEHAVIORAL

the 'gold-standard' behavioral treatment for children/adolescents with posttraumatic stress disorder

Also known as: TF-CBT

Psychotherapy

Eligibility Criteria

• Age: 9 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• ages 12-17, history of physical or sexual abuse, witnessing violence, or bullying; and English speaking

You may not qualify if:

• receiving other psychotherapy currently, taking medications for a psychiatric disorder currently, history of head injury with loss of consciousness longer than 5 minutes; major medical condition such as epilepsy, diabetes, heart disease, or loss of hearing or vision, developmental disorder such as fragile X, autism, or Down's Syndrome, MRI contraindications including metal in the body from an injury or surgery, non-removeable piercings, or braces, Intelligence Quotient (IQ) \< 70; schizophrenia, bipolar disorder, current substance abuse.

Sponsors & Collaborators

• Stanford University: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

Stanford University

Palo Alto, California, 94305, United States

Location

MeSH Terms

Conditions

Memory Disorders; Stress Disorders, Post-Traumatic; Wounds and Injuries

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Study Officials

• Amy S Garrett, Ph.D.

  Stanford University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: February 27, 2013
• First Posted: March 7, 2013
• Study Start: April 1, 2013
• Primary Completion: May 1, 2016
• Study Completion: May 1, 2016
• Last Updated: October 13, 2016

Record last verified: 2016-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)