Investigation of GM Pathology Using Ultra High Field (7T) MRI Scanner

NCT01805986 | Unknown

• 4 other identifiers: 121151392012/EM/0452917
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Magnetization transfer imaging is a magnetic resonance technique that has been used over the last few years, and known for its ability to detect abnormalities that can be difficult to detect by conventional MRI techniques. The investigators would like to test if using an 7 Tesla MRI research scanner can help us diagnose Multiple Sclerosis more efficiently compared to the current clinical practice, i.e. if Multiple Sclerosis lesions in Gray Matter can be more readily identified and associated with disease stage on Magnetic Transfer MRI images as opposed to conventional procedures. Image analysis will allow the investigators to perform lesion segmentation and sequence comparison between different MRI techniques. The investigators will apply computation techniques to measure the local cortical thickness. Repeated scans at 6 monthly intervals over two years will give an insight into the changes in cortical thickness over time. Based on obtained data the investigators will look for the relationship between lesion loads in White Matter and Gray Matter, cortical thickness and disease stage.

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis, other neurological conditions

Outcome Measures

Primary Outcomes (1)

• The number of Gray Matter lesions detected using different sequences.

  2 years

Secondary Outcomes (4)

• Comparison of MRI sequencies

  2 years

• To determine the relationship between cortical thickness as measured on T1 weighted images and GM and WM lesion load.

  2 years

• Regional variation in the brain

  2 years

• To detect cortical variations in MT inside and outside GM lesions, in a longitudinal pilot study, reflecting possible cortical remyelination.

  2 years

Study Arms (1)

MS patient

Eligibility Criteria

• Age: 25 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients studied will be those with known MS. For purposes of comparison as described previously, we will also seek to include healthy volunteers.

You may qualify if:

• Patients with MS or other neurological disease which already had at least 1 MRI scan.
• Healthy volunteers which had no indication of neurological disease in the past.
• Do not have significant cognitive impairment and are able to give consent.
• Will not have any contraindication for MR imaging
• Are able to lie flat for up to 60 mins.
• Age 25 and over.

You may not qualify if:

• Pregnancy
• Have any implants in the body.
• Have aneurysm clips.
• Have pacemaker or artificial heart valve.
• Have foreign bodies in their body (e.g. shrapnel).

Sponsors & Collaborators

• University of Nottingham: lead

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Nikos Evangelou, PhD

  University of Nottingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 5, 2013
• First Posted: March 6, 2013
• Study Start: March 1, 2013
• Primary Completion: February 1, 2014
• Study Completion: February 1, 2015
• Last Updated: May 17, 2013

Record last verified: 2013-05