Influence of Anaesthesia Type on Multiple Sclerosis Relapse

NCT06526130 | Completed

• 1 other identifier: 03072024
• Study Type: observational
• Target: 56
• Locations: 0 countries
• Sites: N/A

Brief Summary

The influence of anesthesia on the course of multiple sclerosis is poorly investigated and the literature is limited. The aim of this study is to investigate multiple sclerosis relapse after different types of anesthesia.

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis; anaesthesia; relapse

Outcome Measures

Primary Outcomes (4)

• Multiple sclerosis relapse after 1 month

  Overall incidence of multiple sclerosis relapse after 1 month after anaesthesia

  1 month

• Multiple sclerosis relapse after 3 months

  Overall incidence of multiple sclerosis relapse after 3 months after anaesthesia

  3 months

• Multiple sclerosis relapse after 6 months

  Overall incidence of multiple sclerosis relapse after 6 months after anaesthesia

  6 months

• Multiple sclerosis relapse after 12 months

  Overall incidence of multiple sclerosis relapse after 12 months after anaesthesia

  12 months

Study Arms (2)

General anaesthesia

Intravenous or volatile general anesthesia was preformed with different type of airway management (endotracheal tube, laryngeal mask and bag mask ventilation)

Procedure: General anaesthesia

Neuraxial anaesthesia

Neuraxial anesthesia was administered using spinal or epidural injections of local anesthetic with or without opioid.

Procedure: Neuraxial anaesthesia

Interventions

General anaesthesia PROCEDURE

Intravenous or volatile general anesthesia was preformed with different type of airway management (endotracheal tube, laryngeal mask and bag mask ventilation)

General anaesthesia

Neuraxial anaesthesia PROCEDURE

spinal or epidural injections of local anesthetic with or without opioid

Neuraxial anaesthesia

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study included adult patientswith multiple sclerosis diagnosis who had undergone general or neuraxial anesthesia in General Hospital Varaždin during the period from 01.01.2012 to 31.12.2022.

You may qualify if:

• multiple sclerosis
• surgical procedure under general anaesthesia
• surgical procedure under neuraxial anaesthesia

You may not qualify if:

• patients (medical records) with incomplete data

Sponsors & Collaborators

• Varazdin General Hospital: lead

MeSH Terms

Conditions

Multiple Sclerosis; Recurrence

Interventions

Anesthesia, General

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anesthesia; Anesthesia and Analgesia

Study Officials

• Monika Kocman Panic, MD

  Varazdin General Hospital, Varazdin, Croatia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 23, 2024
• First Posted: July 29, 2024
• Study Start: January 1, 2012
• Primary Completion: December 31, 2022
• Study Completion: May 16, 2024
• Last Updated: July 30, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share